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The map label for this gene is znuC [H]

Identifier: 218883684

GI number: 218883684

Start: 345144

End: 345923

Strand: Direct

Name: znuC [H]

Synonym: DKAM_0373

Alternate gene names: 218883684

Gene position: 345144-345923 (Clockwise)

Preceding gene: 218883679

Following gene: 218883685

Centisome position: 25.28

GC content: 45.13

Gene sequence:

>780_bases
GTGCACAAGGGATTCGATGTGATTATAGAGTTAATAGATTTAACCGTGAAGAGAGGACATACCCTGGTACTGAACAATTT
AAACGCGGTGTTCGAGGGCCCTGGACTAATACAGGTTATAGGCCCCAATGGGGCTGGCAAAACAACACTGCTTCTCACCA
TCCTAGGCTTAATAAAACCTGTAAAAGGAGCGGTTAGGATCAGGAATACTGAGCTGAAGAATTCGAGTGGAGGATTATAT
AAAACAATATCCTACATCCCTCAAAAATTCTATATACCGAGGGATGCACCGATAACGCTCTGGGAGTTCGTGGAAAGCTA
TATTAGGGCTTACGAAGGAGGTATGCCATTTAGATCCAGCCATACTGTAAATAGGAGAATTGAGTCAGCACTGGAAATGG
CTGGATTACCCAAGGATTCATGGGGTAAGAAGATCAGTGAGTTGAGTGGTGGACAGCTCCAGAGAGCTCTAATGGCTAGA
GTTCTCTCAGTAGATTCAGAGATAATATTGATGGATGAACCCCTCTCCAACATAGACCCCGAGGGAAGGGGGGCGCTGGC
TGAAATCATTGGCAAGCTTTCAAGTAGGAAACTACTCGTGGTGACAAACCATGACCCCGTATTATTGCTGCCATATACCA
GTAAAATACTGTTACTAGGATATGGTGAATACAGGTACGGTGACCCCGACAGCATCCTTTCACGGGAGGTTTTGACGAAA
ATATATAAGAGTTGTGCCATAGTATTCGGAGAGCATGCCCACATAGCGGATTGGCACTAG

Upstream 100 bases:

>100_bases
GTGAAACCAGCAGACTTAACACGGTGATTACTGGGATCAATGCGTGCCCCATGGTTTCACACCTTATGCACAAAATGTTT
ATAAGTCCTTAAATAGATTT

Downstream 100 bases:

>100_bases
GTGGGGATACTTTCTTGAGGATGCTTGAAGGCGAGTTATGGGAGTATAATGGAGTAGTATATATCGCTAAGGGTTTCCAG
CACCCTGAAGGAATGATCGT

Product: ABC transporter ATP binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MHKGFDVIIELIDLTVKRGHTLVLNNLNAVFEGPGLIQVIGPNGAGKTTLLLTILGLIKPVKGAVRIRNTELKNSSGGLY
KTISYIPQKFYIPRDAPITLWEFVESYIRAYEGGMPFRSSHTVNRRIESALEMAGLPKDSWGKKISELSGGQLQRALMAR
VLSVDSEIILMDEPLSNIDPEGRGALAEIIGKLSSRKLLVVTNHDPVLLLPYTSKILLLGYGEYRYGDPDSILSREVLTK
IYKSCAIVFGEHAHIADWH

Sequences:

>Translated_259_residues
MHKGFDVIIELIDLTVKRGHTLVLNNLNAVFEGPGLIQVIGPNGAGKTTLLLTILGLIKPVKGAVRIRNTELKNSSGGLY
KTISYIPQKFYIPRDAPITLWEFVESYIRAYEGGMPFRSSHTVNRRIESALEMAGLPKDSWGKKISELSGGQLQRALMAR
VLSVDSEIILMDEPLSNIDPEGRGALAEIIGKLSSRKLLVVTNHDPVLLLPYTSKILLLGYGEYRYGDPDSILSREVLTK
IYKSCAIVFGEHAHIADWH
>Mature_259_residues
MHKGFDVIIELIDLTVKRGHTLVLNNLNAVFEGPGLIQVIGPNGAGKTTLLLTILGLIKPVKGAVRIRNTELKNSSGGLY
KTISYIPQKFYIPRDAPITLWEFVESYIRAYEGGMPFRSSHTVNRRIESALEMAGLPKDSWGKKISELSGGQLQRALMAR
VLSVDSEIILMDEPLSNIDPEGRGALAEIIGKLSSRKLLVVTNHDPVLLLPYTSKILLLGYGEYRYGDPDSILSREVLTK
IYKSCAIVFGEHAHIADWH

Specific function: Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system [H]

COG id: COG1121

COG function: function code P; ABC-type Mn/Zn transport systems, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI105990541, Length=182, Percent_Identity=24.7252747252747, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI21536376, Length=205, Percent_Identity=23.9024390243902, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788165, Length=233, Percent_Identity=27.4678111587983, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790739, Length=242, Percent_Identity=29.3388429752066, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786803, Length=246, Percent_Identity=29.2682926829268, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1788450, Length=240, Percent_Identity=28.75, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788761, Length=238, Percent_Identity=25.2100840336134, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786345, Length=241, Percent_Identity=27.3858921161826, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790162, Length=205, Percent_Identity=26.3414634146341, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI87081782, Length=197, Percent_Identity=27.9187817258883, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1789891, Length=214, Percent_Identity=25.2336448598131, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788225, Length=260, Percent_Identity=23.8461538461538, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790544, Length=227, Percent_Identity=26.8722466960352, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789864, Length=246, Percent_Identity=24.7967479674797, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI2367384, Length=212, Percent_Identity=27.3584905660377, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789032, Length=229, Percent_Identity=27.0742358078603, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787112, Length=171, Percent_Identity=27.4853801169591, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787500, Length=200, Percent_Identity=27, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786872, Length=232, Percent_Identity=25, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789593, Length=239, Percent_Identity=24.2677824267782, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI87082267, Length=216, Percent_Identity=28.7037037037037, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1786398, Length=178, Percent_Identity=29.2134831460674, Blast_Score=61, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322980, Length=236, Percent_Identity=27.9661016949153, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574259, Length=208, Percent_Identity=29.3269230769231, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017882
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 28677; Mature: 28677

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKGFDVIIELIDLTVKRGHTLVLNNLNAVFEGPGLIQVIGPNGAGKTTLLLTILGLIKP
CCCHHHHHHHHHHHHHHCCCEEEEECCCCEECCCCEEEEECCCCCCHHHHHHHHHHHHHH
VKGAVRIRNTELKNSSGGLYKTISYIPQKFYIPRDAPITLWEFVESYIRAYEGGMPFRSS
CCCCEEEECCCCCCCCCCHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHCCCCCCCCC
HTVNRRIESALEMAGLPKDSWGKKISELSGGQLQRALMARVLSVDSEIILMDEPLSNIDP
CHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
EGRGALAEIIGKLSSRKLLVVTNHDPVLLLPYTSKILLLGYGEYRYGDPDSILSREVLTK
CCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHH
IYKSCAIVFGEHAHIADWH
HHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MHKGFDVIIELIDLTVKRGHTLVLNNLNAVFEGPGLIQVIGPNGAGKTTLLLTILGLIKP
CCCHHHHHHHHHHHHHHCCCEEEEECCCCEECCCCEEEEECCCCCCHHHHHHHHHHHHHH
VKGAVRIRNTELKNSSGGLYKTISYIPQKFYIPRDAPITLWEFVESYIRAYEGGMPFRSS
CCCCEEEECCCCCCCCCCHHHHHHHCCHHEECCCCCCCHHHHHHHHHHHHHCCCCCCCCC
HTVNRRIESALEMAGLPKDSWGKKISELSGGQLQRALMARVLSVDSEIILMDEPLSNIDP
CHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
EGRGALAEIIGKLSSRKLLVVTNHDPVLLLPYTSKILLLGYGEYRYGDPDSILSREVLTK
CCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHH
IYKSCAIVFGEHAHIADWH
HHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA