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The map label for this gene is purP [H]

Identifier: 218710384

GI number: 218710384

Start: 2588917

End: 2590206

Strand: Reverse

Name: purP [H]

Synonym: VS_2421

Alternate gene names: 218710384

Gene position: 2590206-2588917 (Counterclockwise)

Preceding gene: 218710386

Following gene: 218710383

Centisome position: 78.51

GC content: 45.43

Gene sequence:

>1290_bases
ATGTTCGAAAAGCTATTCAAACTCAGTGAAAATGGCACCAATGTGCGCACTGAAATCATCGCAGGTCTAACAACCTTCCT
AACAATGGCTTACATCATTTTTGTAAACCCAATGATTCTAGCTGATGCTGGTATGGACCATGGCGCTGTATTTGTAGCAA
CCTGTTTAGCAGCTGCTATTGGCTGTTTCATCATGGGCTTTGTTGCTAACTACCCAATTGCTCAAGCTCCAGGCATGGGT
TTGAATGCATTCTTTACCTACGCTGTTGTAATGGGGATGGGTTATACGTGGCAAGTTGCTCTGGCAGCGGTTTTCGTATC
AGGCGTGATCTTCATATTCTTAAGCATCTTTAAGATCCGTGAATGGATTATCAACTCGATCCCTATGTCTCTGCGTGTTG
GTATCTCTGCAGGTATCGGTCTTTTCCTAGCGTTTATTGCTCTTAGCAATGCAGGCATCGTTGTTTCTAACCCAGCAACT
AAAGTTTCACTGGGCGACATTACCGCGATTGCTCCTATCCTAGGTGCACTTGGTTTCTTCCTTACGATTGCTCTTGTTCA
CCGTGGTGTAAAAGGTGCAGTGATGATTGCTATTCTAGCTATCACAGCTGTTGGTATTGCTATTGGTGACGTTCAATACG
GCGGCATCATGTCGACACCACCAAGCCTTGCACCAACATTCATGCAGCTTGATTTCTCTGCTGTATTTGAAATAGGTATG
ATTTCAGTAGTATTCGCTTTCTTGTTCGTCGATTTATTCGATACAGCGGGCACTCTGGTTGGTGTTGCAACGAAAGCAAA
CCTAATCAAAGAAGACGGTAAACTGCCTCGTCTGAACAAGGCACTGCTTGCTGACTCAACAGCAACATCAATTGGTGCAC
TGCTAGGTACATCAAATACAACCTCTTACGTTGAGAGTGTTGCGGGTGTCGCTGAAGGCGGCCGTACCGGTCTAACAGCG
GTTGTTGTTGGTATCTTGTTCCTACTGGCTCTTTTCTTCTCACCGCTTGCCGGTATGATTCCAGCCTACGCAACATCAGG
TGCGTTGTTCTATGTAGCAATTTTGATGATGTCTGGCCTAGTTGGTATTGATTGGCGTGATCTTACGGAAGCAGCCCCAG
TCGTGGTAACATGTCTGCTTATGCCGTTGACATACTCTATCGCTGAGGGTATCTCACTAGGCTTCATCGCTTACGCTGCA
ATTAAGCTGCTAAGTGGTAAAGGTCGCGACGTTTCACCTGCTGTGTGGGTAATGTCGGCTATCTTTATTCTTAAATATAC
TTTCGCTTAA

Upstream 100 bases:

>100_bases
AGAGCCTTAATTCTATCTGGAATTTGTTATTTGATAACTTTATAATCCACAGCCAATCGATTACGCAACCGTTTACTTTT
TACCCTTATAGGATTCGATA

Downstream 100 bases:

>100_bases
TCGTCTAGATTTCTGCTTAATCGCTGAAGAGGCTATGTTTGAAATAGCCTCTAATAACATGACAAAATTATTAGGTTTTA
TACTATGAGCAACAAATTCG

Product: permease family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MFEKLFKLSENGTNVRTEIIAGLTTFLTMAYIIFVNPMILADAGMDHGAVFVATCLAAAIGCFIMGFVANYPIAQAPGMG
LNAFFTYAVVMGMGYTWQVALAAVFVSGVIFIFLSIFKIREWIINSIPMSLRVGISAGIGLFLAFIALSNAGIVVSNPAT
KVSLGDITAIAPILGALGFFLTIALVHRGVKGAVMIAILAITAVGIAIGDVQYGGIMSTPPSLAPTFMQLDFSAVFEIGM
ISVVFAFLFVDLFDTAGTLVGVATKANLIKEDGKLPRLNKALLADSTATSIGALLGTSNTTSYVESVAGVAEGGRTGLTA
VVVGILFLLALFFSPLAGMIPAYATSGALFYVAILMMSGLVGIDWRDLTEAAPVVVTCLLMPLTYSIAEGISLGFIAYAA
IKLLSGKGRDVSPAVWVMSAIFILKYTFA

Sequences:

>Translated_429_residues
MFEKLFKLSENGTNVRTEIIAGLTTFLTMAYIIFVNPMILADAGMDHGAVFVATCLAAAIGCFIMGFVANYPIAQAPGMG
LNAFFTYAVVMGMGYTWQVALAAVFVSGVIFIFLSIFKIREWIINSIPMSLRVGISAGIGLFLAFIALSNAGIVVSNPAT
KVSLGDITAIAPILGALGFFLTIALVHRGVKGAVMIAILAITAVGIAIGDVQYGGIMSTPPSLAPTFMQLDFSAVFEIGM
ISVVFAFLFVDLFDTAGTLVGVATKANLIKEDGKLPRLNKALLADSTATSIGALLGTSNTTSYVESVAGVAEGGRTGLTA
VVVGILFLLALFFSPLAGMIPAYATSGALFYVAILMMSGLVGIDWRDLTEAAPVVVTCLLMPLTYSIAEGISLGFIAYAA
IKLLSGKGRDVSPAVWVMSAIFILKYTFA
>Mature_429_residues
MFEKLFKLSENGTNVRTEIIAGLTTFLTMAYIIFVNPMILADAGMDHGAVFVATCLAAAIGCFIMGFVANYPIAQAPGMG
LNAFFTYAVVMGMGYTWQVALAAVFVSGVIFIFLSIFKIREWIINSIPMSLRVGISAGIGLFLAFIALSNAGIVVSNPAT
KVSLGDITAIAPILGALGFFLTIALVHRGVKGAVMIAILAITAVGIAIGDVQYGGIMSTPPSLAPTFMQLDFSAVFEIGM
ISVVFAFLFVDLFDTAGTLVGVATKANLIKEDGKLPRLNKALLADSTATSIGALLGTSNTTSYVESVAGVAEGGRTGLTA
VVVGILFLLALFFSPLAGMIPAYATSGALFYVAILMMSGLVGIDWRDLTEAAPVVVTCLLMPLTYSIAEGISLGFIAYAA
IKLLSGKGRDVSPAVWVMSAIFILKYTFA

Specific function: High-affinity uptake of adenine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790150, Length=428, Percent_Identity=52.1028037383178, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI87082309, Length=423, Percent_Identity=48.936170212766, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1790499, Length=419, Percent_Identity=38.9021479713604, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI48994909, Length=432, Percent_Identity=36.8055555555556, Blast_Score=246, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44856; Mature: 44856

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCC
>Mature Secondary Structure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HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]