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The map label for this gene is murQ

Identifier: 218708578

GI number: 218708578

Start: 566234

End: 567154

Strand: Reverse

Name: murQ

Synonym: VS_0544

Alternate gene names: 218708578

Gene position: 567154-566234 (Counterclockwise)

Preceding gene: 218708579

Following gene: 218708576

Centisome position: 17.19

GC content: 47.77

Gene sequence:

>921_bases
ATGAGTAACGACGCTCTCATATCAGCACTCTCGCACCTCGTTTCGGAGGGGAGAAACCCTGACACTATGGATATTGATCT
GCTCACCTCTCTCGAAGTGGTTGAAAAGATTAACCAACAAGACAAGCAAGTCCCACTGGCGATTGAAGCGGAACTGCCAC
AGATCGCGAAAGCAGTCGATAAAATTGCACAAGCCTTTCAAAACGGTGGTCGACTGATTTATATGGGCGCAGGCACCAGT
GGTCGATTAGGTGTGCTAGACGCCTCAGAGTGCCCTCCGACTTTCGGTGTTTCAGACAAAATGGTTATCGGCTTAATCGC
TGGCGGGCCAGAAGCGATTTTAAAAGCCAAAGAGGGAGCGGAAGATTCGCTGACTCTCGGTATTGAAGATCTCAAAGCAA
TTCAGTTTTCAGAAAATGATGTCGTGGTAGGTATTGCAGCAAGCGGTCGTACACCTTACGTGATTGGTGCGCTCAATTAC
GCCAATCAACTTGGCGCAGTGACGGTTGCATTGTCTTGTAACCCTGATTCTCCGATTGCTGAAATCGCTCAAATCGCAAT
TAGCCCGGTGGTTGGCCCAGAAGCATTGACGGGTTCAACACGACTCAAATCAGGGACAGCACAAAAGCTGGTGCTTAATA
TGCTGACCACAGCCAGCATGATTCGCATTGGTAAGAGCTACCAAAACCTGATGGTCGACGTAAAAGCGACAAATGAAAAG
TTGGTTGCCCGCGCTGCTCGTATCGTTATCCAAGCAACGGAGTGCGAGAAAGCACTGGCGGTGTCGACTCTTAAAGCGAC
TGATTACGATGTGAAGCTATCGATTTTGATGATTCTAACAGGGCTAGATTTAGAACTGGCCAAGGCTCAGCTTGATAAAC
AAAATGGCTTCTTGAGAAAAGCAGTCGAGAATAATCAGTAA

Upstream 100 bases:

>100_bases
AGTGACTGGCGCAAGCAGAGCAGCCTCTCTAGGCGTTCTCTATCGTGCTGACTAAACAAATTTAGAACCATCATTTTAGA
ATCACCATTTAAGGACCATT

Downstream 100 bases:

>100_bases
TCTTAATTTGGTTTGTGGCTTCTCATTTAGACAGCTACTTTAACGACATACAAAAAGACCAGTACACATACGGCACTGGT
CTTTTTAATTTCTAATCGCT

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSNDALISALSHLVSEGRNPDTMDIDLLTSLEVVEKINQQDKQVPLAIEAELPQIAKAVDKIAQAFQNGGRLIYMGAGTS
GRLGVLDASECPPTFGVSDKMVIGLIAGGPEAILKAKEGAEDSLTLGIEDLKAIQFSENDVVVGIAASGRTPYVIGALNY
ANQLGAVTVALSCNPDSPIAEIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRIGKSYQNLMVDVKATNEK
LVARAARIVIQATECEKALAVSTLKATDYDVKLSILMILTGLDLELAKAQLDKQNGFLRKAVENNQ

Sequences:

>Translated_306_residues
MSNDALISALSHLVSEGRNPDTMDIDLLTSLEVVEKINQQDKQVPLAIEAELPQIAKAVDKIAQAFQNGGRLIYMGAGTS
GRLGVLDASECPPTFGVSDKMVIGLIAGGPEAILKAKEGAEDSLTLGIEDLKAIQFSENDVVVGIAASGRTPYVIGALNY
ANQLGAVTVALSCNPDSPIAEIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRIGKSYQNLMVDVKATNEK
LVARAARIVIQATECEKALAVSTLKATDYDVKLSILMILTGLDLELAKAQLDKQNGFLRKAVENNQ
>Mature_305_residues
SNDALISALSHLVSEGRNPDTMDIDLLTSLEVVEKINQQDKQVPLAIEAELPQIAKAVDKIAQAFQNGGRLIYMGAGTSG
RLGVLDASECPPTFGVSDKMVIGLIAGGPEAILKAKEGAEDSLTLGIEDLKAIQFSENDVVVGIAASGRTPYVIGALNYA
NQLGAVTVALSCNPDSPIAEIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRIGKSYQNLMVDVKATNEKL
VARAARIVIQATECEKALAVSTLKATDYDVKLSILMILTGLDLELAKAQLDKQNGFLRKAVENNQ

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Homo sapiens, GI221625433, Length=272, Percent_Identity=27.2058823529412, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788768, Length=294, Percent_Identity=54.7619047619048, Blast_Score=319, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_VIBSL (B7VJM5)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416199.1
- ProteinModelPortal:   B7VJM5
- GeneID:   7160176
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0544
- HOGENOM:   HBG703490
- OMA:   SMIGVGK
- ProtClustDB:   PRK12570
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 32271; Mature: 32139

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 90-90 ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNDALISALSHLVSEGRNPDTMDIDLLTSLEVVEKINQQDKQVPLAIEAELPQIAKAVD
CCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
KIAQAFQNGGRLIYMGAGTSGRLGVLDASECPPTFGVSDKMVIGLIAGGPEAILKAKEGA
HHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCHHHHHCCCCCC
EDSLTLGIEDLKAIQFSENDVVVGIAASGRTPYVIGALNYANQLGAVTVALSCNPDSPIA
CCCEEECHHHHEEEEECCCCEEEEEECCCCCCEEEEECHHHCCCCEEEEEEECCCCCHHH
EIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRIGKSYQNLMVDVKATNEK
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCHH
LVARAARIVIQATECEKALAVSTLKATDYDVKLSILMILTGLDLELAKAQLDKQNGFLRK
HHHHHHHHEEEEHHHHHHHHHHHEECCCCCCEEEEEEEHHCCCHHHHHHHHHHCCCHHHH
AVENNQ
HHCCCC
>Mature Secondary Structure 
SNDALISALSHLVSEGRNPDTMDIDLLTSLEVVEKINQQDKQVPLAIEAELPQIAKAVD
CCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHH
KIAQAFQNGGRLIYMGAGTSGRLGVLDASECPPTFGVSDKMVIGLIAGGPEAILKAKEGA
HHHHHHHCCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCHHHHHCCCCCC
EDSLTLGIEDLKAIQFSENDVVVGIAASGRTPYVIGALNYANQLGAVTVALSCNPDSPIA
CCCEEECHHHHEEEEECCCCEEEEEECCCCCCEEEEECHHHCCCCEEEEEEECCCCCHHH
EIAQIAISPVVGPEALTGSTRLKSGTAQKLVLNMLTTASMIRIGKSYQNLMVDVKATNEK
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCHH
LVARAARIVIQATECEKALAVSTLKATDYDVKLSILMILTGLDLELAKAQLDKQNGFLRK
HHHHHHHHEEEEHHHHHHHHHHHEECCCCCCEEEEEEEHHCCCHHHHHHHHHHCCCHHHH
AVENNQ
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA