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The map label for this gene is ampH [H]

Identifier: 218703656

GI number: 218703656

Start: 450317

End: 451474

Strand: Reverse

Name: ampH [H]

Synonym: ECUMN_0412

Alternate gene names: 218703656

Gene position: 451474-450317 (Counterclockwise)

Preceding gene: 218703660

Following gene: 218703653

Centisome position: 8.68

GC content: 54.84

Gene sequence:

>1158_bases
TTGAAACGTAGTCTGCTTTTTTCTGCCGTGCTGTGTGCGGCGTCATTGACCTCCGTCCATGCGGCGCAGCCGATCACTGA
ACCGGAGTTTGCCTCTGATATTGTCGATCGTTATGCCGATTATATTTTTTACGGCAGCGGTGCCACGGGGATGGCGCTGG
TAGTTATCGACGGTAACCAGCGCGTCTTTCGTAGTTATGGCGAAACGCGACCTGGTAATAACGTTCGCCCGCAGCTGGAT
TCGGTCATACGTATTGCTTCCCTCACCAAGTTAATGACCAGTGAGATGCTGGTGAAATTGCTCGATCAGGGGACCGTGAA
GTTAAACGATCCGCTAAGTAAATATGCTCCGCCAGGCGCACGCGTACCGACCTACAATGGGACGCCCATTACGCTAGTGA
ATCTGGCAACCCATACCAGCGCCCTGCCCCGTGAACAGCCCGGTGGCGCGGCACATCGTCCGGTATTTGTCTGGCCAACG
CGCGAGCAACGCTGGAAATACCTTTCCACTGCCAAACTAAAAGCCGCGCCGGGCAGCCAGGCCGCGTACTCCAACCTTGC
GTTCGACCTGCTGGCAGATGCACTGGCGAATGCGTCCGGCAAGCCTTATACCCAGTTGTTTGAAGAGCAGATTACCCGCC
CATTGGGGATGAAAGACACCACCTACACCCCCTCGCCGGACCAGTGCCGCCGTTTAATGGTTGCTGAGCGTGGTGCCAGT
CCGTGCAATAACACGCTGGCGGCAATTGGCAGCGGCGGAGTCTATTCCACGCCTGGCGATATGATGCGCTGGATGCAGCA
GTATTTGTCATCTGATTTTTATCAGCGCAGTAACCAGGCAGATCGCATGCAGACGTTGATTTATCAGCGCGCGCAGTTTA
CGAAAGTGATTGGCATGGATGTCCCCGGCAAAGCGGACGCGCTTGGTTTAGGCTGGGTATATATGGCCCCGAAAGAGGGT
CGTCCAGGGATTATTCAGAAGACAGGTGGTGGTGGCGGTTTCATTACCTATATGGCGATGATCCCGCAGAAGAACATTGG
CGCATTTGTGGTGGTCACTCGTTCGCCATTGACGCGCTTTAAAAATATGAGCGATGGCATCAATGACCTGGTGACCGAAC
TGAGCGGGAATAAACCGTTGGTCATCCCCGCATCCTGA

Upstream 100 bases:

>100_bases
CGTTTTTAACACTATTATTGCACTAATTCGCCCTTTGCAATCCATCAATGAGTAGTATAAATACGCTCAGTTACCTTCAT
TCAATCTATGGACACCACCG

Downstream 100 bases:

>100_bases
TTAATACTCTGAAGGCAAACGGTTGATAGCGACCAGTTTGCCTTTATTCATTTCGATATAGCCGCCTTTACGTAAAGCAG
CGAGAACTTCTGCGACGACA

Product: beta-lactam binding protein AmpH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADYIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLD
SVIRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPT
REQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGAS
PCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEG
RPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS

Sequences:

>Translated_385_residues
MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADYIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLD
SVIRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPT
REQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGAS
PCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEG
RPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS
>Mature_385_residues
MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADYIFYGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLD
SVIRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPT
REQRWKYLSTAKLKAAPGSQAAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGAS
PCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMDVPGKADALGLGWVYMAPKEG
RPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRFKNMSDGINDLVTELSGNKPLVIPAS

Specific function: Binds penicillin and contributes to the normal morphology [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI239747261, Length=364, Percent_Identity=25, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI239752721, Length=364, Percent_Identity=25, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI239741085, Length=364, Percent_Identity=25, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786574, Length=385, Percent_Identity=99.4805194805195, Blast_Score=793, Evalue=0.0,
Organism=Escherichia coli, GI1790593, Length=372, Percent_Identity=23.6559139784946, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082101, Length=245, Percent_Identity=26.1224489795918, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 41890; Mature: 41890

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADYIFYGSGATGMALVVIDGNQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEEEECCCH
RVFRSYGETRPGNNVRPQLDSVIRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCCC
RVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQ
CCCCCCCCCEEEEEECHHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHEEECCCCCH
AAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGAS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
PCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMD
CCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
VPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRF
CCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCEEHEECCCCCCCCEEEEEECCHHHHH
KNMSDGINDLVTELSGNKPLVIPAS
HHHCCCHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MKRSLLFSAVLCAASLTSVHAAQPITEPEFASDIVDRYADYIFYGSGATGMALVVIDGNQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCCCCEEEEEECCCH
RVFRSYGETRPGNNVRPQLDSVIRIASLTKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCCC
RVPTYNGTPITLVNLATHTSALPREQPGGAAHRPVFVWPTREQRWKYLSTAKLKAAPGSQ
CCCCCCCCCEEEEEECHHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHEEECCCCCH
AAYSNLAFDLLADALANASGKPYTQLFEEQITRPLGMKDTTYTPSPDQCRRLMVAERGAS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
PCNNTLAAIGSGGVYSTPGDMMRWMQQYLSSDFYQRSNQADRMQTLIYQRAQFTKVIGMD
CCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCC
VPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQKNIGAFVVVTRSPLTRF
CCCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCEEHEECCCCCCCCEEEEEECCHHHHH
KNMSDGINDLVTELSGNKPLVIPAS
HHHCCCHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]