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The map label for this gene is uhpC

Identifier: 218697389

GI number: 218697389

Start: 4222326

End: 4223645

Strand: Reverse

Name: uhpC

Synonym: EC55989_4135

Alternate gene names: 218697389

Gene position: 4223645-4222326 (Counterclockwise)

Preceding gene: 218697390

Following gene: 218697388

Centisome position: 81.94

GC content: 55.45

Gene sequence:

>1320_bases
ATGTTGCCGTTTCTGAAAGCGCCTGCCGATGCGCCATTAATGACTGACAAACATGAAATTGATGCCCGCTATCGCTACTG
GCGTCGGCATATTCTGCTGACCATCTGGCTGGGTTACGCGCTGTTTTACTTCACGCGTAAAAGTTTTAACGCCGCCGTAC
CAGAAATCCTTGCTAACGGCGTGCTCAGCCGTAGCGATATCGGCCTGTTAGCGACCCTGTTTTACATTACCTACGGCGTG
TCGAAGTTTGTCTCCGGCATTGTCAGCGATCGCTCAAATGCCCGTTATTTTATGGGGATAGGGCTTATCGCCACGGGCAT
CATCAACATTCTGTTTGGCTTCTCGACGTCGCTATGGGCGTTTGCCGTGCTCTGGGTGCTGAACGCCTTTTTCCAGGGCT
GGGGTTCACCGGTGTGTGCGCGTCTGTTAACGGCCTGGTATTCACGTACCGAGCGCGGCGGTTGGTGGGCATTATGGAAC
ACGGCGCATAACGTCGGCGGCGCACTCATTCCCATTGTGATGGCAGCGGCTGCGCTGCATTACGGCTGGCGTGCCGGGAT
GATGATTGCTGGTTGTATGGCGATAGTCGTGGGGATTTTTCTCTGCTGGCGGCTACGCGATCGCCCGCAGGCGTTAGGTT
TACCGGCGGTCGGTGAATGGCGACACGACGCGCTGGAAATTGCTCAACAACAAGAAGGGGCAGGGTTGACGCGTAAAGAG
ATCCTCACCAAATATGTGTTGCTGAATCCGTATATCTGGCTGCTTTCGTTTTGCTATGTGCTGGTCTATGTGGTCCGGGC
GGCGATCAACGACTGGGGCAATTTGTATATGTCCGAGACACTGGGCGTCGATCTGGTCACGGCGAATACGGCAGTGACGA
TGTTTGAACTGGGCGGATTTATCGGTGCGCTGGTAGCCGGTTGGGGCTCGGACAAATTGTTTAACGGCAACCGTGGGCCG
ATGAATTTGATTTTCGCCGCCGGAATTTTGCTTTCAGTCGGCTCGCTGTGGCTGATGCCATTTGCCAGCTACGTGATGCA
GGCAACCTGCTTCTTCACCATTGGTTTTTTTGTCTTTGGCCCGCAGATGTTAATCGGCATGGCGGCGGCAGAGTGTTCCC
ACAAAGAGGCGGCAGGGGCGGCGACGGGGTTTGTCGGCTTGTTTGCTTATCTGGGGGCGTCGCTTGCTGGTTGGCCGCTG
GCGAAAGTACTCGATACCTGGCACTGGAGCGGATTTTTTGTGGTTATCTCTATCGCCGCCGGGATTTCCGCACTGCTGTT
ACTGCCCTTTTTGAACGCCCAGGCACCGCGCGAAGCGTGA

Upstream 100 bases:

>100_bases
CGAGCGCGTAACGGCGCTGGGCGGCACATTACACATTTCCTGTCTGCACGGCACGCGTGTCAGCGTTTCTCTACCTCAAC
GCTATGTCTAAGGTTCGATG

Downstream 100 bases:

>100_bases
TGCATCTCACCTTTTCACTTCATATCCGGCAAAACTAAGAAATTTTCCAGGTTTTGCCTGGACGCTATCTCAGGCCTGAT
TTGCTGCTGATTTTTACAAT

Product: regulatory protein UhpC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPL
AKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQAPREA

Sequences:

>Translated_439_residues
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPL
AKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQAPREA
>Mature_439_residues
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGV
SKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN
TAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGP
MNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPL
AKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQAPREA

Specific function: UhpC is required for uhpT expression, it may act jointly with the uhpB signaling protein [H]

COG id: COG2271

COG function: function code G; Sugar phosphate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family [H]

Homologues:

Organism=Homo sapiens, GI256219598, Length=436, Percent_Identity=30.045871559633, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI4503847, Length=436, Percent_Identity=30.045871559633, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI256219483, Length=436, Percent_Identity=30.045871559633, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI256219543, Length=450, Percent_Identity=29.5555555555556, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI256219564, Length=366, Percent_Identity=27.8688524590164, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI46361976, Length=470, Percent_Identity=21.4893617021277, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI14150047, Length=291, Percent_Identity=21.9931271477663, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI38093649, Length=470, Percent_Identity=25.1063829787234, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI223717983, Length=470, Percent_Identity=25.1063829787234, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082310, Length=439, Percent_Identity=99.5444191343963, Blast_Score=879, Evalue=0.0,
Organism=Escherichia coli, GI1788573, Length=431, Percent_Identity=38.0510440835267, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI2367259, Length=463, Percent_Identity=33.0453563714903, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI2367379, Length=453, Percent_Identity=22.075055187638, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17542316, Length=451, Percent_Identity=23.9467849223947, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI133901856, Length=444, Percent_Identity=23.1981981981982, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI133901854, Length=444, Percent_Identity=23.1981981981982, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17561094, Length=398, Percent_Identity=21.8592964824121, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI133930953, Length=444, Percent_Identity=21.8468468468468, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24656861, Length=416, Percent_Identity=26.4423076923077, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24656866, Length=416, Percent_Identity=26.4423076923077, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI45550478, Length=416, Percent_Identity=26.4423076923077, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000849
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR021159 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48201; Mature: 48201

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50850 MFS ; PS00942 GLPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCHHHHHHHHHH
GISALLLLPFLNAQAPREA
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLPFLKAPADAPLMTDKHEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALH
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCHHHCCHHHHHHHHHHHHHH
YGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
ILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHH
IGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFG
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHCCCHHHHHHHHHH
GISALLLLPFLNAQAPREA
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1569007; 11677609 [H]