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The map label for this gene is dppB

Identifier: 218697255

GI number: 218697255

Start: 4071380

End: 4072399

Strand: Reverse

Name: dppB

Synonym: EC55989_3994

Alternate gene names: 218697255

Gene position: 4072399-4071380 (Counterclockwise)

Preceding gene: 218697257

Following gene: 218697254

Centisome position: 79.0

GC content: 56.47

Gene sequence:

>1020_bases
ATGTTGCAGTTTATTCTCCGACGTTTGGGACTCGTCATCCCCACGTTTATCGGTATTACCCTTCTCACATTTGCCTTTGT
CCACATGATCCCGGGCGATCCGGTGATGATCATGGCGGGCGAACGTGGGATCTCCCCAGAGCGTCACGCGCAGCTGCTGG
CTGAACTCGGCTTAGATAAACCGATGTGGCAGCAGTATCTCCATTACATTTGGGGCGTTATGCATGGCGATCTAGGCATT
TCAATGAAAAGCCGCATCCCGGTTTGGGAAGAGTTCGTGCCGCGCTTCCAGGCCACGCTGGAACTTGGCGTCTGCGCGAT
GATTTTTGCTACGGCAGTCGGTATTCCGGTCGGCGTGCTGGCTGCGGTTAAACGCGGTTCCATTTTCGATCACACAGCGG
TTGGCCTGGCGCTGACCGGCTACTCGATGCCGATCTTCTGGTGGGGCATGATGCTGATCATGCTGGTTTCGGTGCACTGG
AACCTGACGCCCGTCTCCGGTCGCGTGAGCGATATGGTGTTCCTCGATGATTCCAATCCGTTAACCGGTTTTATGCTGAT
CGACACCGCCATCTGGGGTGAAGATGGCAACTTTATCGATGCCGTTGCCCATATGATCTTACCGGCCATTGTGCTGGGTA
CTATTCCGCTGGCGGTCATTGTGCGTATGACACGCTCCTCGATGCTGGAAGTGCTGGGTGAAGATTACATCCGCACCGCG
CGCGCCAAAGGGTTGACCCGCATGCGGGTGATTATCGTCCATGCGCTGCGTAACGCGATGCTGCCGGTAGTGACCGTTAT
CGGCCTCCAGGTGGGAACATTGCTGGCGGGGGCGATTCTGACCGAAACCATTTTCTCGTGGCCCGGTCTGGGGCGCTGGT
TGATTGACGCACTGCAACGCCGCGATTATCCGGTGGTACAGGGCGGCGTATTGCTGGTGGCGACGATGATTATCCTCGTC
AACCTGCTGGTCGATCTGCTGTACGGCGTGGTGAACCCGCGTATTCGTCATAAGAAGTAA

Upstream 100 bases:

>100_bases
CAGCAATACTTCATTCCCTGCCCGACCTGGGCGGGAATTGATTTGTGAGCAATACAGACACGCAGTTCCAGGCTGCGGGT
CACTATAGAGAATCCGGGTT

Downstream 100 bases:

>100_bases
GGGGACATCATGTCACAGGTTACTGAAAATAAAGTGATTAGCGCACCGGTGCCGATGACCCCGTTACAGGAGTTCTGGCA
CTATTTTAAACGCAACAAAG

Product: dipeptide transporter permease DppB

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGI
SMKSRIPVWEEFVPRFQATLELGVCAMIFATAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHW
NLTPVSGRVSDMVFLDDSNPLTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTA
RAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILV
NLLVDLLYGVVNPRIRHKK

Sequences:

>Translated_339_residues
MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGI
SMKSRIPVWEEFVPRFQATLELGVCAMIFATAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHW
NLTPVSGRVSDMVFLDDSNPLTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTA
RAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILV
NLLVDLLYGVVNPRIRHKK
>Mature_339_residues
MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDKPMWQQYLHYIWGVMHGDLGI
SMKSRIPVWEEFVPRFQATLELGVCAMIFATAVGIPVGVLAAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHW
NLTPVSGRVSDMVFLDDSNPLTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTA
RAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQRRDYPVVQGGVLLVATMIILV
NLLVDLLYGVVNPRIRHKK

Specific function: Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain

Homologues:

Organism=Escherichia coli, GI1789965, Length=339, Percent_Identity=100, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI1787053, Length=342, Percent_Identity=42.1052631578947, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1787761, Length=329, Percent_Identity=43.7689969604863, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1787550, Length=283, Percent_Identity=38.1625441696113, Blast_Score=207, Evalue=6e-55,
Organism=Escherichia coli, GI1789888, Length=341, Percent_Identity=32.8445747800587, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1787497, Length=340, Percent_Identity=35.2941176470588, Blast_Score=194, Evalue=7e-51,
Organism=Escherichia coli, GI1788504, Length=378, Percent_Identity=27.5132275132275, Blast_Score=136, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DPPB_ECO57 (P0AEG0)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   C86028
- PIR:   G91181
- RefSeq:   NP_290124.1
- RefSeq:   NP_312450.1
- ProteinModelPortal:   P0AEG0
- EnsemblBacteria:   EBESCT00000028541
- EnsemblBacteria:   EBESCT00000057354
- GeneID:   915716
- GeneID:   961075
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4960
- KEGG:   ecs:ECs4423
- GeneTree:   EBGT00050000009815
- HOGENOM:   HBG724229
- OMA:   MLVSVQL
- ProtClustDB:   PRK10914
- BioCyc:   ECOL83334:ECS4423-MONOMER
- InterPro:   IPR000515

Pfam domain/function: PF00528 BPD_transp_1

EC number: NA

Molecular weight: Translated: 37498; Mature: 37498

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1d9dea9c)-; HASH(0x1d5a0b38)-; HASH(0x1d1a2a84)-; HASH(0x1ad60ee4)-; HASH(0x1d52f404)-; HASH(0x1d08a118)-; HASH(0x1d3c2780)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
PMWQQYLHYIWGVMHGDLGISMKSRIPVWEEFVPRFQATLELGVCAMIFATAVGIPVGVL
HHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHWNLTPVSGRVSDMVFLDDSNP
HHHHCCCCCHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEEECCCC
LTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTA
CEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RDYPVVQGGVLLVATMIILVNLLVDLLYGVVNPRIRHKK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure
MLQFILRRLGLVIPTFIGITLLTFAFVHMIPGDPVMIMAGERGISPERHAQLLAELGLDK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCC
PMWQQYLHYIWGVMHGDLGISMKSRIPVWEEFVPRFQATLELGVCAMIFATAVGIPVGVL
HHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AAVKRGSIFDHTAVGLALTGYSMPIFWWGMMLIMLVSVHWNLTPVSGRVSDMVFLDDSNP
HHHHCCCCCHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCEECCCCCEEEEEEECCCC
LTGFMLIDTAIWGEDGNFIDAVAHMILPAIVLGTIPLAVIVRMTRSSMLEVLGEDYIRTA
CEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAKGLTRMRVIIVHALRNAMLPVVTVIGLQVGTLLAGAILTETIFSWPGLGRWLIDALQR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RDYPVVQGGVLLVATMIILVNLLVDLLYGVVNPRIRHKK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796