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The map label for this gene is pcoA [H]

Identifier: 218697176

GI number: 218697176

Start: 3973375

End: 3975198

Strand: Reverse

Name: pcoA [H]

Synonym: EC55989_3906

Alternate gene names: 218697176

Gene position: 3975198-3973375 (Counterclockwise)

Preceding gene: 218697179

Following gene: 218697175

Centisome position: 77.12

GC content: 51.81

Gene sequence:

>1824_bases
ATGCGCATGCTGTTGAAAACGTCTCGACGAACTTTCCTGAAGGGGTTAACCCTCTCTGGCGTAGCCGGAAGTCTTGGCGT
ATGGAGTTTCAATGCGCGTTCCAGTCTGAGCCTGCCAGTTGCCGCATCCCTGCAGGGTACTCAGTTTGACCTGACCATTG
GTGAAACGGCCGTCAATATCACGGGCAGTGAGCGTCAGGCCAAAACAATCAATGGAGGCCTGCCGGGGCCCGTTCTTCGC
TGGAAAGAAGGTGACACCATTACCCTGAAGGTCAAAAACCGTCTTAATGAACAGACGTCCATTCACTGGCACGGCATTAT
TCTTCCGGCCAATATGGATGGTGTTCCGGGGCTGAGTTTTATGGGCATAGAGCCTGATGATACCTACGTTTACACCTTTA
AGGTTAAGCAGAACGGGACTTACTGGTACCACAGCCATTCCGGTCTGCAGGAACAGGAGGGGGTATACGGTGCCATTATC
ATCGATGCCGGGGAGCCAGAACCGTTTACTTACGATCGTGAGCATGTGGTCATGTTGTCTGACTGGACCGATGAAAATCC
TCACAGCCTGCTGAAAAAATTAAAAAAACAGTCGGATTACTACAATTTCAATAAACCAACCGTTGGCTCTTTTTTCCGCG
ACGTGAATACCAGGGGGCTGTCAGCCACCATTGCCGATCGGAAAATGTGGGCTGAAATGAAAATGAATCCGACTGACCTC
GCGGATGTCAGTGGCTACACCTACACCTATCTCATGAACGGGCAGGCCCCGCTGAAAAACTGGACCGGACTGTTCCGTCC
CGGTGAAAAGATACGCTTACGGTTTATCAACGGCTCGGCAATGACCTATTTCGATATCCGTATCCCCGGGCTGAAAATGA
CGGTCGTGGCTGCAGATGGCCAGTATGTAAACCCGGTTACCGTTGACGAATTCAGGATTGCCGTTGCCGAAACCTATGAT
GTCATTGTGGAGCCTCAGGGTGAGGCCTATACCATCTTCGCACAATCCATGGACAGGACCGGTTACGCTCGAGGGACACT
GGCCACGAGAGAGGGGTTAAGTGCTGCCGTTCCCCCCCTCGATCCCCGTCCTCTGTTGACCATGGAAGATATGGGTATGG
GGGGAATGGGACATGATATGGCAGGAATGGACCACAGCCAGATGGGAGGCATGGATAACAGCGGAGAGATGATGTCTATG
GACGGTGCTGACCTTCCGGATAGCGGGACATCCTCCGCGCCCATGGATCACAGCAGCATGGCCGGTATGGATCATTCCCG
GATGGCCGGAATGCCGGGTATGCAAAGTCATCCTGCGTCAGAAACGGATAACCCACTGGTTGATATGCAGGCGATGAGCG
TCTCTCCGAAATTAAATGATCCGGGTATTGGTCTTCGAAATAACGGAAGAAAGGTTCTCACGTACGCGGATTTGAAAAGC
CGCTTTGAGGATCCTGACGGACGTGAACCTGGCCGTACCATAGAACTGCATTTAACCGGCCACATGGAAAAGTTTGCCTG
GTCATTTAACGGAATCAAGTTTTCAGATGCCGCACCGGTGCTGCTGAAATACGGTGAGCGGCTCAGGATCACGCTGATCA
ACGATACCATGATGACTCACCCCATTCACCTGCATGGTATGTGGAGCGATCTGGAAGATGAAAACGGTAATTTCATGGTT
CGTAAACACACAATAGATGTTCCCCCTGGTACAAAACGCAGTTACAGAGTGACAGCAGATGCGCTTGGCCGCTGGGCGTA
TCACTGCCATTTGCTCTATCACATGGAAATGGGAATGTTTCGTGAAGTCCGGGTGGAGGAATGA

Upstream 100 bases:

>100_bases
TTAAGGTGTGCTAGATTCATTTCATTGTAAGTGGATGAACCAGTAATTTAATTTAAATCGGTTCTCGAATTCTGTCAGTA
ACCATACTTTAAATAAGGGA

Downstream 100 bases:

>100_bases
TGCGAATGAAGAGAAATTTGAAGGCCATACCTGTTCTGGTCGCCGGTTTGTTTACCTCACAGCTTTCTATTGCGGCGGGC
TCCGTCTCTGCAGATCCCCA

Product: Copper resistance protein A precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MRMLLKTSRRTFLKGLTLSGVAGSLGVWSFNARSSLSLPVAASLQGTQFDLTIGETAVNITGSERQAKTINGGLPGPVLR
WKEGDTITLKVKNRLNEQTSIHWHGIILPANMDGVPGLSFMGIEPDDTYVYTFKVKQNGTYWYHSHSGLQEQEGVYGAII
IDAGEPEPFTYDREHVVMLSDWTDENPHSLLKKLKKQSDYYNFNKPTVGSFFRDVNTRGLSATIADRKMWAEMKMNPTDL
ADVSGYTYTYLMNGQAPLKNWTGLFRPGEKIRLRFINGSAMTYFDIRIPGLKMTVVAADGQYVNPVTVDEFRIAVAETYD
VIVEPQGEAYTIFAQSMDRTGYARGTLATREGLSAAVPPLDPRPLLTMEDMGMGGMGHDMAGMDHSQMGGMDNSGEMMSM
DGADLPDSGTSSAPMDHSSMAGMDHSRMAGMPGMQSHPASETDNPLVDMQAMSVSPKLNDPGIGLRNNGRKVLTYADLKS
RFEDPDGREPGRTIELHLTGHMEKFAWSFNGIKFSDAAPVLLKYGERLRITLINDTMMTHPIHLHGMWSDLEDENGNFMV
RKHTIDVPPGTKRSYRVTADALGRWAYHCHLLYHMEMGMFREVRVEE

Sequences:

>Translated_607_residues
MRMLLKTSRRTFLKGLTLSGVAGSLGVWSFNARSSLSLPVAASLQGTQFDLTIGETAVNITGSERQAKTINGGLPGPVLR
WKEGDTITLKVKNRLNEQTSIHWHGIILPANMDGVPGLSFMGIEPDDTYVYTFKVKQNGTYWYHSHSGLQEQEGVYGAII
IDAGEPEPFTYDREHVVMLSDWTDENPHSLLKKLKKQSDYYNFNKPTVGSFFRDVNTRGLSATIADRKMWAEMKMNPTDL
ADVSGYTYTYLMNGQAPLKNWTGLFRPGEKIRLRFINGSAMTYFDIRIPGLKMTVVAADGQYVNPVTVDEFRIAVAETYD
VIVEPQGEAYTIFAQSMDRTGYARGTLATREGLSAAVPPLDPRPLLTMEDMGMGGMGHDMAGMDHSQMGGMDNSGEMMSM
DGADLPDSGTSSAPMDHSSMAGMDHSRMAGMPGMQSHPASETDNPLVDMQAMSVSPKLNDPGIGLRNNGRKVLTYADLKS
RFEDPDGREPGRTIELHLTGHMEKFAWSFNGIKFSDAAPVLLKYGERLRITLINDTMMTHPIHLHGMWSDLEDENGNFMV
RKHTIDVPPGTKRSYRVTADALGRWAYHCHLLYHMEMGMFREVRVEE
>Mature_607_residues
MRMLLKTSRRTFLKGLTLSGVAGSLGVWSFNARSSLSLPVAASLQGTQFDLTIGETAVNITGSERQAKTINGGLPGPVLR
WKEGDTITLKVKNRLNEQTSIHWHGIILPANMDGVPGLSFMGIEPDDTYVYTFKVKQNGTYWYHSHSGLQEQEGVYGAII
IDAGEPEPFTYDREHVVMLSDWTDENPHSLLKKLKKQSDYYNFNKPTVGSFFRDVNTRGLSATIADRKMWAEMKMNPTDL
ADVSGYTYTYLMNGQAPLKNWTGLFRPGEKIRLRFINGSAMTYFDIRIPGLKMTVVAADGQYVNPVTVDEFRIAVAETYD
VIVEPQGEAYTIFAQSMDRTGYARGTLATREGLSAAVPPLDPRPLLTMEDMGMGGMGHDMAGMDHSQMGGMDNSGEMMSM
DGADLPDSGTSSAPMDHSSMAGMDHSRMAGMPGMQSHPASETDNPLVDMQAMSVSPKLNDPGIGLRNNGRKVLTYADLKS
RFEDPDGREPGRTIELHLTGHMEKFAWSFNGIKFSDAAPVLLKYGERLRITLINDTMMTHPIHLHGMWSDLEDENGNFMV
RKHTIDVPPGTKRSYRVTADALGRWAYHCHLLYHMEMGMFREVRVEE

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=451, Percent_Identity=25.2771618625277, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539950, Length=313, Percent_Identity=25.2396166134185, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321067, Length=600, Percent_Identity=23.8333333333333, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323703, Length=314, Percent_Identity=30.2547770700637, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320714, Length=298, Percent_Identity=25.503355704698, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574104, Length=623, Percent_Identity=24.0770465489567, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24650186, Length=610, Percent_Identity=23.1147540983607, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360167, Length=313, Percent_Identity=27.1565495207668, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585842, Length=313, Percent_Identity=27.1565495207668, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI221330000, Length=313, Percent_Identity=27.1565495207668, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI221329998, Length=313, Percent_Identity=27.1565495207668, Blast_Score=97, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18859919, Length=277, Percent_Identity=26.7148014440433, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 67527; Mature: 67527

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMLLKTSRRTFLKGLTLSGVAGSLGVWSFNARSSLSLPVAASLQGTQFDLTIGETAVNI
CCCHHHHHHHHHHCCCEECCCCCCCEEEEECCCCCCCCCEEECCCCCEEEEEECCEEEEE
TGSERQAKTINGGLPGPVLRWKEGDTITLKVKNRLNEQTSIHWHGIILPANMDGVPGLSF
ECCCCCCEECCCCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCEEE
MGIEPDDTYVYTFKVKQNGTYWYHSHSGLQEQEGVYGAIIIDAGEPEPFTYDREHVVMLS
EECCCCCCEEEEEEEECCCEEEEECCCCCCHHCCEEEEEEEECCCCCCCEECCCEEEEEE
DWTDENPHSLLKKLKKQSDYYNFNKPTVGSFFRDVNTRGLSATIADRKMWAEMKMNPTDL
CCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCH
ADVSGYTYTYLMNGQAPLKNWTGLFRPGEKIRLRFINGSAMTYFDIRIPGLKMTVVAADG
HHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEEEECCEEEEEEEECC
QYVNPVTVDEFRIAVAETYDVIVEPQGEAYTIFAQSMDRTGYARGTLATREGLSAAVPPL
CEECCEEHHHEEEEEEEEEEEEECCCCCEEEEEEECCCCCCCCCCCEEHHCCCCCCCCCC
DPRPLLTMEDMGMGGMGHDMAGMDHSQMGGMDNSGEMMSMDGADLPDSGTSSAPMDHSSM
CCCCEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHH
AGMDHSRMAGMPGMQSHPASETDNPLVDMQAMSVSPKLNDPGIGLRNNGRKVLTYADLKS
CCCCHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEHHH
RFEDPDGREPGRTIELHLTGHMEKFAWSFNGIKFSDAAPVLLKYGERLRITLINDTMMTH
HCCCCCCCCCCCEEEEEEECCCEEEEEEECCEEECCCCCHHHHCCCEEEEEEEECCEEEC
PIHLHGMWSDLEDENGNFMVRKHTIDVPPGTKRSYRVTADALGRWAYHCHLLYHMEMGMF
CEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCEEEEEHHHHCCCEEEEEEEEEECCCCE
REVRVEE
EEEEECC
>Mature Secondary Structure
MRMLLKTSRRTFLKGLTLSGVAGSLGVWSFNARSSLSLPVAASLQGTQFDLTIGETAVNI
CCCHHHHHHHHHHCCCEECCCCCCCEEEEECCCCCCCCCEEECCCCCEEEEEECCEEEEE
TGSERQAKTINGGLPGPVLRWKEGDTITLKVKNRLNEQTSIHWHGIILPANMDGVPGLSF
ECCCCCCEECCCCCCCCEEEECCCCEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCEEE
MGIEPDDTYVYTFKVKQNGTYWYHSHSGLQEQEGVYGAIIIDAGEPEPFTYDREHVVMLS
EECCCCCCEEEEEEEECCCEEEEECCCCCCHHCCEEEEEEEECCCCCCCEECCCEEEEEE
DWTDENPHSLLKKLKKQSDYYNFNKPTVGSFFRDVNTRGLSATIADRKMWAEMKMNPTDL
CCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCH
ADVSGYTYTYLMNGQAPLKNWTGLFRPGEKIRLRFINGSAMTYFDIRIPGLKMTVVAADG
HHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEEEECCEEEEEEEECC
QYVNPVTVDEFRIAVAETYDVIVEPQGEAYTIFAQSMDRTGYARGTLATREGLSAAVPPL
CEECCEEHHHEEEEEEEEEEEEECCCCCEEEEEEECCCCCCCCCCCEEHHCCCCCCCCCC
DPRPLLTMEDMGMGGMGHDMAGMDHSQMGGMDNSGEMMSMDGADLPDSGTSSAPMDHSSM
CCCCEEEECCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHH
AGMDHSRMAGMPGMQSHPASETDNPLVDMQAMSVSPKLNDPGIGLRNNGRKVLTYADLKS
CCCCHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEHHH
RFEDPDGREPGRTIELHLTGHMEKFAWSFNGIKFSDAAPVLLKYGERLRITLINDTMMTH
HCCCCCCCCCCCEEEEEEECCCEEEEEEECCEEECCCCCHHHHCCCEEEEEEEECCEEEC
PIHLHGMWSDLEDENGNFMVRKHTIDVPPGTKRSYRVTADALGRWAYHCHLLYHMEMGMF
CEEEEEECCCCCCCCCCEEEEEEEEECCCCCCCEEEEEHHHHCCCEEEEEEEEEECCCCE
REVRVEE
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]