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The map label for this gene is tdcC

Identifier: 218696822

GI number: 218696822

Start: 3617262

End: 3618593

Strand: Reverse

Name: tdcC

Synonym: EC55989_3533

Alternate gene names: 218696822

Gene position: 3618593-3617262 (Counterclockwise)

Preceding gene: 218696823

Following gene: 218696821

Centisome position: 70.2

GC content: 49.7

Gene sequence:

>1332_bases
ATGAGTACTTCAGATAGCATTGTATCCAGCCAGACAAAACAATCGTCCTGGCGTAAATCAGATACCACATGGACGTTAGG
CTTGTTTGGTACGGCAATCGGCGCCGGGGTGCTGTTCTTCCCTATCCGCGCAGGTTTTGGCGGACTGATCCCGATTCTTC
TGATGTTGGTATTGGCATACCCCATCGCATTTTATTGCCACCGGGCGCTGGCGCGTCTGTGTCTTTCTGGCTCTAACCCT
TCCGGCAACATTACGGAAACGGTGGAAGAGCATTTTGGTAAAACTGGCGGCGTGGTTATCACGTTCCTGTACTTCTTCGC
GATTTGCCCACTGCTGTGGATTTATGGCGTTACTATTACCAATACCTTTATGACGTTCTGGGAAAACCAGCTCGGATTTG
CACCGCTGAATCGCGGCTTTGTGGCGCTGTTCCTGTTGCTGCTGATGGCTTTCGTCATCTGGTTTGGTAAGGATCTGATG
GTTAAAGTGATGAGCTACCTGGTATGGCCGTTTATCGCCAGCCTGGTGCTGATTTCTCTGTCGCTGATCCCTTACTGGAA
CTCTGCAGTTATCGACCAGGTTGACCTCGGTTCGCTGTCGTTAACCGGTCATGACGGTATCCTGATCACTGTCTGGCTGG
GGATTTCCATCATGGTTTTCTCCTTTAACTTCTCGCCAATCGTCTCTTCCTTCGTGGTTTCTAAACGTGAAGAGTATGAG
AAAGACTTCGGTCGCGACTTCACCGAACGTAAATGTTCCCAAATCATTTCTCGTGCCAGCATGCTGATGGTTGCAGTGGT
GATGTTCTTTGCCTTTAGCTGCCTGTTTACGCTGTCTCCGGCCAACATGGCGGAAGCCAAAGCGCAGAATATTCCAGTGC
TTTCTTATCTGGCTAACCACTTTGCGTCCATGACCGGTACCAAAACAACGTTCGCGATTACACTGGAATATGCGGCTTCC
ATCATCGCACTCGTGGCTATCTTCAAATCTTTCTTCGGTCACTATCTGGGGACGCTGGAAGGCTTGAATGGTCTGATTCT
GAAGTTCGGTTATAAAGGCGACAAAACTAAAGTGTCGCTGGGTAAACTGAACACTATCAGCATGATCTTCATCATGGGCT
CCACCTGGGTTGTTGCCTACGCCAACCCGAACATCCTCGACCTTATTGAAGCCATGGGCGCACCGATTATCGCATCCCTG
CTGTGCCTGTTGCCGATGTATGCCATCCGTAAAGCGCCGTCTCTGGCGAAATACCGTGGTCGTCTGGATAACGTGTTTGT
TACCGTGATTGGTCTGCTGACCATCCTGAACATCGTATACAAACTGTTTTAA

Upstream 100 bases:

>100_bases
AAAAACCGTCAGTATTATTTCCGGCGGCAATATCGATCTTTCTCGCGTCTCTCAAATCACCGGTTTCGTTGACGCTTAAT
TAATTCGTTGAGGATAGGAT

Downstream 100 bases:

>100_bases
TCCGTAACTCAGGATGAGAAAAGAGATGAATGAATTTCCGGTTGTTTTGGTTATTAACTGTGGTTCGTCTTCGATTAAGT
TTTCCGTACTCGATGCCAGC

Product: threonine/serine transporter TdcC

Products: Proton [Cytoplasm]; D-serine [Cytoplasm]; L-threonine [Cytoplasm] [C]

Alternate protein names: H(+)/threonine-serine symporter [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNP
SGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLM
VKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYE
KDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAAS
IIALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASL
LCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF

Sequences:

>Translated_443_residues
MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNP
SGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLM
VKVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYE
KDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAAS
IIALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASL
LCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF
>Mature_442_residues
STSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPS
GNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMV
KVMSYLVWPFIASLVLISLSLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYEK
DFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFAITLEYAASI
IALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSLGKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLL
CLLPMYAIRKAPSLAKYRGRLDNVFVTVIGLLTILNIVYKLF

Specific function: Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=99.7742663656885, Blast_Score=892, Evalue=0.0,
Organism=Escherichia coli, GI1789160, Length=442, Percent_Identity=50.6787330316742, Blast_Score=440, Evalue=1e-124,
Organism=Escherichia coli, GI1789211, Length=420, Percent_Identity=30.7142857142857, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI145693183, Length=436, Percent_Identity=25.4587155963303, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1789961, Length=428, Percent_Identity=24.7663551401869, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 48894; Mature: 48762

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAY
CCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
PIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTIT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
SLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYE
HHHCCCCCHHHCCCCCCCEEECCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
FASMTGTKTTFAITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSL
HHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEC
GKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRG
CCCCHHHEEEEECCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHH
RLDNVFVTVIGLLTILNIVYKLF
HHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
STSDSIVSSQTKQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAY
CCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
PIAFYCHRALARLCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTIT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISL
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
SLIPYWNSAVIDQVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYE
HHHCCCCCHHHCCCCCCCEEECCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KDFGRDFTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANH
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
FASMTGTKTTFAITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLILKFGYKGDKTKVSL
HHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEC
GKLNTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRG
CCCCHHHEEEEECCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHH
RLDNVFVTVIGLLTILNIVYKLF
HHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm]; L-threonine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] Proton [Periplasm] + L-threonine [Periplasm] = Proton [Cytoplasm] + L-threonine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA