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The map label for this gene is exuR

Identifier: 218696802

GI number: 218696802

Start: 3600302

End: 3601078

Strand: Direct

Name: exuR

Synonym: EC55989_3512

Alternate gene names: 218696802

Gene position: 3600302-3601078 (Clockwise)

Preceding gene: 218696797

Following gene: 218696803

Centisome position: 69.84

GC content: 50.32

Gene sequence:

>777_bases
ATGGAAATCACTGAACCACGCCGTTTGTATCAACAACTTGCCGCTGACCTGAAAGAGCGCATCGAACAGGGCGTCTATCT
GGTAGGTGATAAACTGCCTGCAGAACGCTTTATTGCCGATGAAAAGAACGTCAGCCGTACGGTAGTTCGTGAAGCCATCA
TCATGCTGGAAGTTGAAGGCTATGTCGAAGTGCGTAAAGGTTCAGGTATTCATGTGGTTTCCAACCAGCCGCGCCATCAG
CAGGCAGCTGACAATAATATGGAATTCGCCAATTACGGTCCGTTTGAGTTGCTTCAGGCTCGCCAGCTCATCGAAAGTAA
TATTGCCGAATTCGCGGCAACTCAGGTAACGAAACAGGACATCATGAAACTGATGGCCATTCAGGAACAGGCGCGCGGCG
AACAATGCTTCCGTGATTCCGAGTGGGATTTACAGTTCCACATTCAGGTAGCCCTGGCGACGCAGAACTCCGCCCTGGCG
GCCATCGTTGAAAAAATGTGGACACAACGTAGCCATAACCCGTACTGGAAAAAACTGCACGAACACATTGATTCCCGTAC
CGTCGATAACTGGTGTGATGACCACGATCAAATCCTCAAGGCGCTGATTCGCAAAGATCCTCATGCTGCTAAGCTGGCAA
TGTGGCAGCACCTGGAAAACACCAAGATCATGTTATTCAACGAAACCAGCGACGACTTCGAGTTCAATGCCGACCGCTAT
CTATTCGCCGAAAACCCGGTGGTGCATCTCGATACGGCCACCAGTGGCAGTAAATGA

Upstream 100 bases:

>100_bases
AATACATTAATTCAATCACCAAATTTATATATGACCAATGGCATACCCATGAATAAAGTGGTATGATAACTTCGTCCGCA
TTCCACTCCGGGAGACGCAT

Downstream 100 bases:

>100_bases
AATACCTGTCCGACAGGCGCTGCGACGCGCCTGTTTGTCTCGTCGGTAAGCGAAAAGTATAAAGTGTCAGCCTGTGTAAA
TCCTCTCGCCACCCTCCCCT

Product: DNA-binding transcriptional repressor ExuR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ
QAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALA
AIVEKMWTQRSHNPYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
LFAENPVVHLDTATSGSK

Sequences:

>Translated_258_residues
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ
QAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALA
AIVEKMWTQRSHNPYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
LFAENPVVHLDTATSGSK
>Mature_258_residues
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPRHQ
QAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQDIMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALA
AIVEKMWTQRSHNPYWKKLHEHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
LFAENPVVHLDTATSGSK

Specific function: Repressor for the exu regulon that encode genes involved in hexuronate utilization. It regulates the exuT, uxaCA and uxuRAB operons. Binds D-tagaturonate and D-fructuronate as inducers

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI87082208, Length=258, Percent_Identity=100, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI1790780, Length=255, Percent_Identity=46.2745098039216, Blast_Score=207, Evalue=4e-55,
Organism=Escherichia coli, GI1790032, Length=237, Percent_Identity=27.0042194092827, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789353, Length=244, Percent_Identity=24.1803278688525, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EXUR_ECO57 (P0ACL3)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- RefSeq:   NP_289668.2
- RefSeq:   NP_312003.2
- ProteinModelPortal:   P0ACL3
- SMR:   P0ACL3
- EnsemblBacteria:   EBESCT00000028292
- EnsemblBacteria:   EBESCT00000060023
- GeneID:   916189
- GeneID:   958563
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4448
- KEGG:   ecs:ECs3976
- GeneTree:   EBGT00050000009602
- HOGENOM:   HBG700007
- OMA:   SGIHVIS
- ProtClustDB:   PRK11523
- BioCyc:   ECOL83334:ECS3976-MONOMER
- GO:   GO:0005622
- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00035
- SMART:   SM00895
- SMART:   SM00345

Pfam domain/function: PF07729 FCD; PF00392 GntR

EC number: NA

Molecular weight: Translated: 29836; Mature: 29836

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG
CCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHEEECC
YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD
EEEEECCCCEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHH
EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
HHHHCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCEECCCEE
LFAENPVVHLDTATSGSK
EEECCCEEEEECCCCCCC
>Mature Secondary Structure
MEITEPRRLYQQLAADLKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEG
CCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHEEECC
YVEVRKGSGIHVVSNQPRHQQAADNNMEFANYGPFELLQARQLIESNIAEFAATQVTKQD
EEEEECCCCEEEECCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IMKLMAIQEQARGEQCFRDSEWDLQFHIQVALATQNSALAAIVEKMWTQRSHNPYWKKLH
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHH
EHIDSRTVDNWCDDHDQILKALIRKDPHAAKLAMWQHLENTKIMLFNETSDDFEFNADRY
HHHHCCCHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCEECCCEE
LFAENPVVHLDTATSGSK
EEECCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796