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The map label for this gene is plsC

Identifier: 218696726

GI number: 218696726

Start: 3515065

End: 3515802

Strand: Reverse

Name: plsC

Synonym: EC55989_3434

Alternate gene names: 218696726

Gene position: 3515802-3515065 (Counterclockwise)

Preceding gene: 218696727

Following gene: 218696725

Centisome position: 68.2

GC content: 49.46

Gene sequence:

>738_bases
ATGCTATATATCTTTCGTCTTATTATTACCTTGATTTACAGCATCTTAGTCTGTGTATTCGGCTCCATTTACTGCCTTTT
CAGCCCGCGTAACCCGAAACATGTGGCCACCTTTGGGCATATGTTTGGCCGTCTTGCGCCGCTGTTCGGCCTGAAAGTTG
AGTGCCGCAAACCTGCAGATGCTGAAAGCTACGGCAATGCTATCTATATCGCTAACCACCAGAACAACTATGACATGGTG
ACAGCATCGAACATTGTGCAACCGCCGACGGTGACGGTAGGTAAAAAGAGCTTGCTGTGGATCCCCTTCTTCGGGCAGTT
GTACTGGTTAACCGGCAACTTATTGATCGACAGAAACAATCGCACTAAAGCTCACGGCACCATTGCGGAAGTCGTGAATC
ATTTCAAAAAACGCCGTATTTCCATCTGGATGTTCCCGGAAGGAACCCGCAGCCGTGGTCGCGGCCTGCTACCGTTCAAG
ACTGGAGCATTTCACGCGGCAATTGCGGCGGGCGTCCCGATTATTCCCGTGTGCGTCTCTACAACTTCGAATAAGATTAA
TCTTAATCGACTGCACAACGGTCTGGTGATTGTCGAAATGCTGCCGCCAATTGACGTCAGTCAGTATGGCAAAGATCAGG
TTCGTGAGCTGGCTGCCCATTGTCGTTCGATAATGGAACAAAAAATCGCCGAGCTCGATAAAGAAGTCGCAGAACGCGAA
GCCGCCGGAAAAGTTTAA

Upstream 100 bases:

>100_bases
CGATTAACAATACGCTTTTCCAGAGAGCGGCTTTTAACAATGCCCTAACCTGATTTCAGGTGACGTACAATGCCAGTCTC
TCAGACCTTCAGAGGGTGTT

Downstream 100 bases:

>100_bases
GTCGGCAATCTGTATTTTTGCGGGGAACACTTTCCTGCACGGTATTACTTTAGCCAGTTTTACATGGAGCAAATATGTCA
CTCAGTCGGCGTCAGTTCAT

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLYIFRLIITLIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV
TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFK
TGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE
AAGKV

Sequences:

>Translated_245_residues
MLYIFRLIITLIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV
TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFK
TGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE
AAGKV
>Mature_245_residues
MLYIFRLIITLIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPADAESYGNAIYIANHQNNYDMV
TASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNNRTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFK
TGAFHAAIAAGVPIIPVCVSTTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE
AAGKV

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=235, Percent_Identity=28.0851063829787, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI15100175, Length=235, Percent_Identity=28.0851063829787, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI6041665, Length=231, Percent_Identity=27.7056277056277, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1789395, Length=245, Percent_Identity=99.1836734693878, Blast_Score=507, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17564032, Length=183, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17568319, Length=214, Percent_Identity=33.6448598130841, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320151, Length=169, Percent_Identity=37.8698224852071, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI281364648, Length=236, Percent_Identity=29.2372881355932, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24582856, Length=236, Percent_Identity=29.2372881355932, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24582854, Length=236, Percent_Identity=29.2372881355932, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24641614, Length=214, Percent_Identity=34.5794392523364, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24641612, Length=214, Percent_Identity=34.5794392523364, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27438; Mature: 27438

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYIFRLIITLIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPAD
CCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCC
AESYGNAIYIANHQNNYDMVTASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNN
HHHHCCEEEEEECCCCCCEEEECCCCCCCCEEECCCEEEEEEHHCEEEEEECEEEEECCC
RTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS
CCCHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEE
TTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE
CCCCEEEHEECCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGKV
HCCCC
>Mature Secondary Structure
MLYIFRLIITLIYSILVCVFGSIYCLFSPRNPKHVATFGHMFGRLAPLFGLKVECRKPAD
CCHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCCEEECCCCCC
AESYGNAIYIANHQNNYDMVTASNIVQPPTVTVGKKSLLWIPFFGQLYWLTGNLLIDRNN
HHHHCCEEEEEECCCCCCEEEECCCCCCCCEEECCCEEEEEEHHCEEEEEECEEEEECCC
RTKAHGTIAEVVNHFKKRRISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVS
CCCHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEE
TTSNKINLNRLHNGLVIVEMLPPIDVSQYGKDQVRELAAHCRSIMEQKIAELDKEVAERE
CCCCEEEHEECCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAGKV
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1557036; 9278503 [H]