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The map label for this gene is sdaC

Identifier: 218696395

GI number: 218696395

Start: 3145542

End: 3146831

Strand: Direct

Name: sdaC

Synonym: EC55989_3075

Alternate gene names: 218696395

Gene position: 3145542-3146831 (Clockwise)

Preceding gene: 218696394

Following gene: 218696396

Centisome position: 61.02

GC content: 52.48

Gene sequence:

>1290_bases
ATGGAAACGACTCAAACCAGCACGATTGCGTCGAAAGACTCTCGTAGTGCCTGGCGCAAGACAGACACCATGTGGATGCT
GGGCCTTTACGGCACGGCAATCGGCGCGGGCGTGCTGTTCCTGCCAATCAACGCCGGTGTTGGCGGTATGATCCCGCTGA
TCATCATGGCTATCCTTGCGTTCCCGATGACGTTTTTTGCTCACCGCGGCCTGACTCGCTTCGTACTGTCTGGTAAAAAC
CCGGGCGAAGACATCACCGAGGTTGTAGAAGAACACTTTGGTATTGGCGCAGGTAAACTGATTACCCTGCTCTACTTCTT
CGCTATCTACCCGATCCTGCTGGTTTATAGCGTGGCAATCACCAATACCGTTGAAAGCTTCATGTCTCACCAGCTGGGTA
TGACGCCACCGCCGCGTGCGATTCTGTCGCTGATCCTGATCGTGGGTATGATGACCATCGTTCGCTTTGGTGAGCAGATG
ATCGTTAAAGCGATGAGTATTCTGGTATTCCCGTTTGTTGGCGTACTGATGCTGCTGGCTCTGTACCTGATCCCGCAGTG
GAACGGCGCAGCACTGGAAACGCTGTCTCTGGACACTGCATCTGCAACCGGAAACGGTCTGTGGATGACCCTGTGGCTGG
CAATTCCGGTAATGGTGTTCTCGTTCAACCACTCTCCGATCATCTCTTCTTTCGCCGTTGCGAAGCGTGAAGAGTACGGC
GATATGGCAGAACAGAAATGCTCGAAGATCCTGGCATTCGCACACATCATGATGGTGCTGACCGTAATGTTCTTCGTCTT
CAGCTGCGTACTGAGCCTGACTCCGGCAGACCTGGCTGCGGCTAAAGAGCAGAACATCTCGATTCTGTCTTACCTGGCTA
ACCACTTTAACGCACCGGTTATCGCGTGGATGGCTCCGATTATCGCGATTATCGCTATCACCAAATCCTTCCTCGGCCAC
TACCTGGGCGCACGTGAAGGCTTCAACGGTATGGTGATTAAATCTCTGCGTGGTAAAGGTAAGTCTATCGAAATCAACAA
GCTGAACCGTATCACTGCGCTGTTCATGCTGGTAACGACCTGGATTGTTGCCACCCTGAACCCGAGCATCCTGGGTATGA
TTGAAACCCTGGGCGGCCCAATCATCGCGATGATCCTGTTCCTGATGCCGATGTACGCAATTCAGAAAGTACCGGCAATG
CGTAAGTACAGCGGTCACATCAGCAACGTATTCGTTGTCGTGATGGGTCTGATTGCAATCTCCGCAATCTTCTACTCTCT
GTTCAGCTAA

Upstream 100 bases:

>100_bases
AAGCCATCGCCGATAGACAGATTTCATTTTTACGGTCAGGCACCTTCCCGGGCTGAACTGGCTAAAAGCTGAATTATTTG
CATTCCTCCAGGAGAAATAG

Downstream 100 bases:

>100_bases
GTCCTTTCGCGCCGCTTTCGGGCGGCGCTTCCTCCGTTTTAACGCGATGTATTTCCTATGATTAGCGTATTCGATATTTT
CAAAATCGGCATTGGCCCTT

Product: putative serine transporter

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
METTQTSTIASKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKN
PGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFMSHQLGMTPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSILVFPFVGVLMLLALYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
DMAEQKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPVIAWMAPIIAIIAITKSFLGH
YLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVVMGLIAISAIFYSLFS

Sequences:

>Translated_429_residues
METTQTSTIASKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKN
PGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFMSHQLGMTPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSILVFPFVGVLMLLALYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
DMAEQKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPVIAWMAPIIAIIAITKSFLGH
YLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVVMGLIAISAIFYSLFS
>Mature_429_residues
METTQTSTIASKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILAFPMTFFAHRGLTRFVLSGKN
PGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAITNTVESFMSHQLGMTPPPRAILSLILIVGMMTIVRFGEQM
IVKAMSILVFPFVGVLMLLALYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
DMAEQKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPVIAWMAPIIAIIAITKSFLGH
YLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTTWIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAM
RKYSGHISNVFVVVMGLIAISAIFYSLFS

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily

Homologues:

Organism=Escherichia coli, GI1789160, Length=429, Percent_Identity=100, Blast_Score=861, Evalue=0.0,
Organism=Escherichia coli, GI1789504, Length=442, Percent_Identity=50.9049773755656, Blast_Score=447, Evalue=1e-127,
Organism=Escherichia coli, GI1789211, Length=415, Percent_Identity=38.7951807228916, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI145693183, Length=422, Percent_Identity=28.9099526066351, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789961, Length=411, Percent_Identity=25.3041362530414, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SDAC_ECO57 (P0AAD7)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   B85931
- PIR:   H91085
- RefSeq:   NP_289351.1
- RefSeq:   NP_311683.1
- ProteinModelPortal:   P0AAD7
- EnsemblBacteria:   EBESCT00000027485
- EnsemblBacteria:   EBESCT00000057119
- GeneID:   916539
- GeneID:   958263
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z4113
- KEGG:   ecs:ECs3656
- GeneTree:   EBGT00050000008986
- HOGENOM:   HBG296888
- OMA:   MSVLVFP
- ProtClustDB:   CLSK880493
- BioCyc:   ECOL83334:ECS3656-MONOMER
- InterPro:   IPR004694
- InterPro:   IPR018227
- TIGRFAMs:   TIGR00814

Pfam domain/function: PF03222 Trp_Tyr_perm

EC number: NA

Molecular weight: Translated: 46907; Mature: 46907

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1bfc3678)-; HASH(0x1bc78f0c)-; HASH(0x1bdfdbdc)-; HASH(0x1bfdf53c)-; HASH(0x1c02380c)-; HASH(0x1c0da96c)-; HASH(0x1c02df68)-; HASH(0x1c200c98)-; HASH(0x1b21bd1c)-; HASH(0x1c009344)-; HASH(0x18cb709c)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
6.5 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTQTSTIASKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILA
CCCCCCHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPMTFFAHRGLTRFVLSGKNPGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNTVESFMSHQLGMTPPPRAILSLILIVGMMTIVRFGEQMIVKAMSILVFPFVGVLMLLA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
HHHCCCCCCCEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DMAEQKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCH
IAWMAPIIAIIAITKSFLGHYLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
WIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAMRKYSGHISNVFVVVMGLIAI
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
SAIFYSLFS
HHHHHHHHH
>Mature Secondary Structure
METTQTSTIASKDSRSAWRKTDTMWMLGLYGTAIGAGVLFLPINAGVGGMIPLIIMAILA
CCCCCCHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHH
FPMTFFAHRGLTRFVLSGKNPGEDITEVVEEHFGIGAGKLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TNTVESFMSHQLGMTPPPRAILSLILIVGMMTIVRFGEQMIVKAMSILVFPFVGVLMLLA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYLIPQWNGAALETLSLDTASATGNGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYG
HHHCCCCCCCEEHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DMAEQKCSKILAFAHIMMVLTVMFFVFSCVLSLTPADLAAAKEQNISILSYLANHFNAPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCH
IAWMAPIIAIIAITKSFLGHYLGAREGFNGMVIKSLRGKGKSIEINKLNRITALFMLVTT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
WIVATLNPSILGMIETLGGPIIAMILFLMPMYAIQKVPAMRKYSGHISNVFVVVMGLIAI
HHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHH
SAIFYSLFS
HHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796