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The map label for this gene is hisI

Identifier: 218695652

GI number: 218695652

Start: 2327641

End: 2328252

Strand: Direct

Name: hisI

Synonym: EC55989_2285

Alternate gene names: 218695652

Gene position: 2327641-2328252 (Clockwise)

Preceding gene: 218695651

Following gene: 218695686

Centisome position: 45.15

GC content: 53.43

Gene sequence:

>612_bases
ATGTTAACAGAACAACAACGTCGCGAACTGGACTGGGAAAAAACCGACGGACTGATGCCGGTGATTGTGCAACACGCGGT
ATCCGGCGAAGTGTTAATGCTGGGCTATATGAACCCGGAAGCCTTAGACAAAACCATCGAAAGCGGCAAAGTCACCTTCT
TCTCGCGCACTAAACAGCGACTGTGGACCAAAGGCGAAACGTCGGGCAATTTCCTCAACGTAGTAAATATTGCGCCGGAC
TGCGACAACGACACGCTACTGGTACTGGCGAATCCTATCGGACCAACCTGCCACAAAGGCACCAGCAGCTGCTTCGGCGA
CACCGCTCACCAATGGATGTTCCTGTATCAACTGGAACAACTGCTCGCCGAACGCAAATCTGCCGACCCGGAAACCTCCT
ACACCGCCAAACTGTATGCCAGCGGCACCAAGCGCATTGCGCAAAAAGTAGGCGAAGAAGGCGTGGAAACCGCACTGGCA
GCAACGGTACATGACCGCTTTGAGCTGACCAACGAGGCATCTGACTTGATGTATCACCTGCTGGTGCTGTTGCAGGATCA
GGATCTGGACTTAACGACGGTGATTGAGAACCTGCGTAAACGGCATCAGTGA

Upstream 100 bases:

>100_bases
ACGTTGACGGCGCGCTGGCTGCTTCCGTATTCCACAAACAAATAATCAATATTGGTGAATTAAAAGCGTACCTGGCAACA
CAGGGCGTGGAGATCAGGAT

Downstream 100 bases:

>100_bases
GTTGCGGGGTAAGCGGATGCGATGTTGTTGTCGCATCCGGCAAAAAAAAACGGGCAAGGTGTCACCACCCTGCCCGTTTT
CTTTAAAGCTGCAAAGATTA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTIESGKVTFFSRTKQRLWTKGETSGNFLNVVNIAPD
CDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWMFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
ATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ

Sequences:

>Translated_203_residues
MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTIESGKVTFFSRTKQRLWTKGETSGNFLNVVNIAPD
CDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWMFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
ATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ
>Mature_203_residues
MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTIESGKVTFFSRTKQRLWTKGETSGNFLNVVNIAPD
CDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWMFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA
ATVHDRFELTNEASDLMYHLLVLLQDQDLDLTTVIENLRKRHQ

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=203, Percent_Identity=98.0295566502463, Blast_Score=417, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6319819, Length=204, Percent_Identity=35.2941176470588, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 22859; Mature: 22859

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTIESGKVTFFSRTKQR
CCCHHHHHCCCCHHCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCEEEHHHHHHH
LWTKGETSGNFLNVVNIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWMFLYQLEQ
HHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHCHHHHHHHHHHHHHH
LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL
HHHHHHCCCCCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLLQDQDLDLTTVIENLRKRHQ
HHHHCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTIESGKVTFFSRTKQR
CCCHHHHHCCCCHHCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCEEEHHHHHHH
LWTKGETSGNFLNVVNIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWMFLYQLEQ
HHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHCHHHHHHHHHHHHHH
LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL
HHHHHHCCCCCCCCEEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLLQDQDLDLTTVIENLRKRHQ
HHHHCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10222209; 11206551; 11258796 [H]