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The map label for this gene is uvrY

Identifier: 218695520

GI number: 218695520

Start: 2180628

End: 2181284

Strand: Reverse

Name: uvrY

Synonym: EC55989_2134

Alternate gene names: 218695520

Gene position: 2181284-2180628 (Counterclockwise)

Preceding gene: 218695523

Following gene: 218695519

Centisome position: 42.32

GC content: 49.62

Gene sequence:

>657_bases
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGACAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Upstream 100 bases:

>100_bases
AATACCCACCATTTTTAACGTTTCAAAGTTGCAATAAAAACCGCTAATATACGAATGACTAACTATCAGTAGCGTTATCC
CTATTTCTGGAGATATTCCT

Downstream 100 bases:

>100_bases
GTGATCAGTTTGACGCAAAAGCGTTTTTAAAAACCGTAACCAGCCAGCCAGGCGTTTATCGCATGTACGATGCTGGTGGT
ACGGTTATCTATGTCGGCAA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Sequences:

>Translated_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ
>Mature_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=218, Percent_Identity=100, Blast_Score=449, Evalue=1e-128,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=36.5, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=32.0388349514563, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=27.8048780487805, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=27.536231884058, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787473, Length=184, Percent_Identity=29.3478260869565, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788546, Length=207, Percent_Identity=26.5700483091787, Blast_Score=78, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23893; Mature: 23893

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCC
GGLEATRKIARSTADVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCEEEEEEECCCCCC
GGLEATRKIARSTADVKIIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYS
CCHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]