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The map label for this gene is phoP

Identifier: 218694664

GI number: 218694664

Start: 1300024

End: 1300695

Strand: Reverse

Name: phoP

Synonym: EC55989_1243

Alternate gene names: 218694664

Gene position: 1300695-1300024 (Counterclockwise)

Preceding gene: 218694665

Following gene: 218694663

Centisome position: 25.23

GC content: 47.62

Gene sequence:

>672_bases
ATGCGCGTACTGGTTGTTGAAGACAATGCGTTGTTACGTCACCACCTTAAAGTTCAGATTCAGGATGCTGGTCATCAGGT
CGATGACGCAGAAGATGCCAAAGAAGCCGATTATTATCTCAATGAACATTTACCGGATATTGCGATTGTCGATCTCGGAT
TGCCTGACGAGGACGGTCTGTCACTGATTCGCCGCTGGCGTAGCAATGATGTTTCACTGCCGATTCTGGTATTAACCGCC
CGTGAAAGCTGGCAGGACAAAGTCGAAGTATTAAGTGCCGGTGCTGATGATTACGTGACTAAACCGTTTCATATTGAAGA
GGTGATGGCGCGAATGCAGGCATTAATGCGGCGTAATAGCGGCCTGGCTTCACAGGTCATTTCGCTACCCCCGTTTCAGG
TTGATCTCTCTCGCCGTGAATTATCTATTAATGACGAAGTGATCAAACTGACCGCGTTCGAATACACCATTATGGAAACG
TTGATACGCAATAATGGCAAAGTGGTGAGCAAAGATTCGTTAATGCTCCAACTCTATCCGGATGCGGAGCTGCGGGAAAG
CCATACCATTGATGTACTGATGGGACGTCTGCGCAAAAAAATTCAGGCACAATATCCGCAAGAAGTGATTACTACCGTTC
GCGGCCAGGGCTATTTGTTCGAATTGCGCTGA

Upstream 100 bases:

>100_bases
TCACTTTACCTCCCCTCCCCGCTGGTTTATTTAATGTTTACCCCCATAAACACATAATCGCGTTACACTATTTTAATAAT
TAAGACAGGGAGAAATAAAA

Downstream 100 bases:

>100_bases
TGAAAAAATTACTGCGTCTTTTTTTCCCGCTCTCACTGCGGGTACGTTTTCTGTTGGCAACGGCTGCGGTAGTACTGGTG
CTTTCGCTTGCCTACGGAAT

Product: DNA-binding transcriptional regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTA
RESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMET
LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR

Sequences:

>Translated_223_residues
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTA
RESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMET
LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
>Mature_223_residues
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTA
RESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMET
LIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=99.5515695067265, Blast_Score=452, Evalue=1e-129,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=35.2678571428571, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=34.5454545454545, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=35.3211009174312, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=32.8888888888889, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=34.6491228070175, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=33.4821428571429, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=34.703196347032, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=28.6363636363636, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=30.2631578947368, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=31.8385650224215, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.5154185022026, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=28.2608695652174, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI145693140, Length=241, Percent_Identity=26.9709543568465, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790299, Length=108, Percent_Identity=31.4814814814815, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI145693157, Length=106, Percent_Identity=31.1320754716981, Blast_Score=60, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25536; Mature: 25536

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGL
CEEEEEECCHHEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHH
SLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYP
CCHHHHHCCCCCEEECCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEC
>Mature Secondary Structure
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGL
CEEEEEECCHHEEEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCHHHH
SLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYP
CCHHHHHCCCCCEEECCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCEEECCCEEEEECC
DAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
CCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA