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The map label for this gene is cysQ [H]

Identifier: 218692606

GI number: 218692606

Start: 5004844

End: 5005584

Strand: Direct

Name: cysQ [H]

Synonym: ECED1_5073

Alternate gene names: 218692606

Gene position: 5004844-5005584 (Clockwise)

Preceding gene: 218692604

Following gene: 218692608

Centisome position: 96.07

GC content: 54.79

Gene sequence:

>741_bases
ATGTTAGATCAAGTATGCCAGCTTGCACGGAATGCAGGCGATGCCATTATGCAGGTCTACGACGGGACGAAACCGATGGA
CGTCGTCAGCAAAGCGGACAATTCTCCGGTAACGGCAGCGGATATTGCCGCTCACACCGTTATCATGGACGGTTTACGTA
CGCTGACACCGGATATTCCGGTCCTTTCTGAAGAAGATCCTCCCGGTTGGGAAGTCCGTCAGCACTGGCAGCGTTACTGG
CTGGTAGACCCGCTGGATGGTACTAAAGAGTTTATTAAACGTAATGGCGAATTCACCGTTAACATTGCGCTCATCGACCA
CGGTAAACCGATTTTAGGTGTGGTGTATGCGCCGGTAATGAACGTAATGTACAGCGCGGCAGAAGGCAAAGCCTGGAAAG
AAGAGTGCGGTGTGCGCAAGCAGATTCAGGTCCGCGATGCGCGCCCGCCGCTGGTGGTGATCAGCCGTTCCCATGCAGAT
GCGGAGCTGAAAGAGTATCTGCAACAGCTTGGCGAACATCAGACCACGTCCATCGGCTCTTCGCTGAAATTCTGCCTGGT
GGCGGAAGGACAGGCGCAGCTGTACCCGCGTTTCGGGCCAACGAATATTTGGGATACCGCCGCTGGTCATGCTGTGGCTG
CAGCTGCCGGAGCGCACGTTCACGACTGGCAGGGTAAACCGCTGGATTACACTCCGCGCGAGTTGTTCCTGAATCCGGGG
TTCAGAGTGTCTATTTATTAA

Upstream 100 bases:

>100_bases
GCTTTGAAAATGATGACACTATCACAGTTGGCGCATTCATTAACGATAGGGTATAAGTAAAACAATAAGTTAACACCGCT
CACAGAGACGAGGTGGAGAA

Downstream 100 bases:

>100_bases
TTAATTTATGCAGCAGGTCCATCACTTGCTGCACCTCTTCCTGAGTAAGTGCCCCGTCTTTGGCCCATTGCACGCGACCG
TCTTTATCCAGCACCACTAC

Product: adenosine-3'(2'),5'-bisphosphate nucleotidase

Products: NA

Alternate protein names: 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; DPNPase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRELFLNPG
FRVSIY

Sequences:

>Translated_246_residues
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRELFLNPG
FRVSIY
>Mature_246_residues
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIPVLSEEDPPGWEVRQHWQRYW
LVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVMNVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHAD
AELKEYLQQLGEHQTTSIGSSLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRELFLNPG
FRVSIY

Specific function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) [H]

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=250, Percent_Identity=28, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI221625487, Length=250, Percent_Identity=28, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1790659, Length=246, Percent_Identity=99.1869918699187, Blast_Score=509, Evalue=1e-146,
Organism=Escherichia coli, GI1788882, Length=233, Percent_Identity=28.3261802575107, Blast_Score=87, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71995897, Length=265, Percent_Identity=27.9245283018868, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71995905, Length=264, Percent_Identity=27.6515151515151, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=251, Percent_Identity=25.4980079681275, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320493, Length=229, Percent_Identity=25.3275109170306, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641722, Length=230, Percent_Identity=26.5217391304348, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357303, Length=165, Percent_Identity=29.0909090909091, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24664926, Length=238, Percent_Identity=23.9495798319328, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006240
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.7 [H]

Molecular weight: Translated: 27216; Mature: 27216

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIP
CHHHHHHHHHCCCHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVM
CCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
NVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGS
HHHHHHHCCCHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRELFLNPG
CEEEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCHHHEEECCC
FRVSIY
EEEEEC
>Mature Secondary Structure
MLDQVCQLARNAGDAIMQVYDGTKPMDVVSKADNSPVTAADIAAHTVIMDGLRTLTPDIP
CHHHHHHHHHCCCHHHHHHHCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VLSEEDPPGWEVRQHWQRYWLVDPLDGTKEFIKRNGEFTVNIALIDHGKPILGVVYAPVM
CCCCCCCCCHHHHHHHHHEEECCCCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHH
NVMYSAAEGKAWKEECGVRKQIQVRDARPPLVVISRSHADAELKEYLQQLGEHQTTSIGS
HHHHHHHCCCHHHHHCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCC
SLKFCLVAEGQAQLYPRFGPTNIWDTAAGHAVAAAAGAHVHDWQGKPLDYTPRELFLNPG
CEEEEEEECCCCEECCCCCCCCCCCCCCCCHHHHHCCCCEECCCCCCCCCCHHHEEECCC
FRVSIY
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]