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The map label for this gene is cycA [H]

Identifier: 218692598

GI number: 218692598

Start: 4996029

End: 4997432

Strand: Direct

Name: cycA [H]

Synonym: ECED1_5065

Alternate gene names: 218692598

Gene position: 4996029-4997432 (Clockwise)

Preceding gene: 218692597

Following gene: 218692599

Centisome position: 95.9

GC content: 51.35

Gene sequence:

>1404_bases
ATGGTAGATCAGGTAAAAGTCGTTGCCGATGATCAGTCTCCGGCTGAACAGTCGCTACGGCGCAATCTCACAAACCGACA
TATTCAGCTTATTGCCATTGGCGGTGCCATTGGTACAGGGTTGTTTATGGGGTCCGGCAAAACGATTAACCTTGCCGGGC
CGTCGATCATTTTCGTTTATATGATCATCGGTTTTATGCTCTTTTTCGTGATGCGGGCAATGGGGGAATTGCTGCTTTCG
AATCTGGAATACAAATCTTTTAGTGACTTCGCTTCCGATTTACTCGGGCCGTGGGCAGGATATTTCACCGGCTGGACTTA
CTGGTTCTGCTGGGTTGTAACCGGTATGGCAGATGTGGTTGCCATTACCGCCTATGCGCAATTCTGGTTCCCTGGGCTTT
CTGACTGGGTTGCTTCGTTATCCGTGATCATTCTGTTACTGGTTCTAAACCTCGCCACGGTAAAAATGTTCGGTGAGATG
GAGTTCTGGTTTGCGATGATCAAAATCGTCGCCATCGTGTCGCTGATTGTTGTCGGCCTGGTCATGGTGGCGATGCACTT
TCAGTCACCGACCGGTGTGGAAGCATCATTTGCACATTTGTGGAATGACGGCGGCTGGTTCCCGAAAGGCTTAAGCGGCT
TCTTTGCCGGATTCCAGATAGCGGTTTTCGCTTTCGTGGGGATTGAGCTGGTAGGTACAACAGCTGCGGAAACCAAAGAT
CCGGAGAAATCACTGCCACGCGCGATTAACTCTATTCCGATCCGTATCATTATGTTCTACGTCTTCTCGCTGATTGTGAT
TATGTCCGTGACGCCGTGGAGTTCGGTAGTCCCGGAGAAAAGCCCGTTCGTTGAACTGTTTGTGTTGGTAGGTTTGCCTG
CGGCTGCCAGCGTGATCAACTTTGTGGTGCTGACCTCTGCGGCGTCTTCCGCTAACAGCGGTGTCTTCTCTACCAGCCGT
ATGCTGTTTGGCCTGGCCCAGGAAGGTGTGGCACCGAAAGCGTTCGCTAAACTCTCTAAGCGCGCAGTACCCGCGAAAGG
GCTGACCTTCTCTTGTATCTGTCTGCTCGGCGGCGTGGTGATGTTGTATGTGAATCCCAGCGTGATTGGCGCGTTCACGA
TGATTACAACCGTTTCCGCGATTCTGTTTATGTTTGTCTGGACGATTATCCTTTGCTCGTACCTGGTGTATCGCAAACAG
CGTCCTCATCTGCATGAGAAGTCGATCTACAAGATGCCACTCGGCAAGCTGATGTGCTGGGTATGTATGGCGTTCTTTGT
GTTTGTTCTGGTGTTGTTGACACTGGAAGATGACACCCGCCAGGCGCTGCTGGTTACCCCGCTGTGGTTTATCGCGCTGG
GGCTGGGCTGGCTGTTTATTGGTAAAAAACGCATGGCGAAGTAA

Upstream 100 bases:

>100_bases
TACCTAATATCGATGAGTCCCGATACAGATTCGTCGTATCATAGACTGACTAAAGGCCGTAGAGCCTGAACAACACAGAC
AGGTACAGGAAGAAAAAAAC

Downstream 100 bases:

>100_bases
TGCCGCGTTTATAACTCTGAAAGGCACCTGCGGGTGCCTTTGTCTTTATATATTCCTAAAAAAATCTACCATCATAGACA
GCCCTCAGGCGCGAGCTTAC

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MVDQVKVVADDQSPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRMAK

Sequences:

>Translated_467_residues
MVDQVKVVADDQSPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRMAK
>Mature_467_residues
MVDQVKVVADDQSPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEM
EFWFAMIKIVAIVSLIVVGLVMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQ
RPHLHEKSIYKMPLGKLMCWVCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRMAK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=367, Percent_Identity=22.3433242506812, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI115648063, Length=369, Percent_Identity=25.4742547425474, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI115648022, Length=369, Percent_Identity=25.4742547425474, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI114326544, Length=363, Percent_Identity=21.763085399449, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI114326550, Length=363, Percent_Identity=21.763085399449, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI181337167, Length=340, Percent_Identity=21.7647058823529, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI258645169, Length=375, Percent_Identity=22.4, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1790653, Length=467, Percent_Identity=97.8586723768737, Blast_Score=922, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=458, Percent_Identity=40.8296943231441, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1786602, Length=457, Percent_Identity=41.1378555798687, Blast_Score=338, Evalue=4e-94,
Organism=Escherichia coli, GI1786789, Length=453, Percent_Identity=38.4105960264901, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI48994972, Length=461, Percent_Identity=38.8286334056399, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI87081915, Length=456, Percent_Identity=37.5, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI87081708, Length=465, Percent_Identity=32.9032258064516, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1788480, Length=453, Percent_Identity=33.3333333333333, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1789017, Length=447, Percent_Identity=30.8724832214765, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI2367353, Length=399, Percent_Identity=24.5614035087719, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082023, Length=351, Percent_Identity=21.0826210826211, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=362, Percent_Identity=25.414364640884, Blast_Score=82, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=448, Percent_Identity=22.5446428571429, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=461, Percent_Identity=32.3210412147505, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=426, Percent_Identity=31.2206572769953, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320772, Length=447, Percent_Identity=29.7539149888143, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322892, Length=421, Percent_Identity=29.9287410926366, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=416, Percent_Identity=30.7692307692308, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=26.3285024154589, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=399, Percent_Identity=28.8220551378446, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324059, Length=459, Percent_Identity=29.1938997821351, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=421, Percent_Identity=27.790973871734, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=437, Percent_Identity=27.2311212814645, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321053, Length=410, Percent_Identity=27.0731707317073, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319542, Length=400, Percent_Identity=25.25, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319824, Length=399, Percent_Identity=26.0651629072682, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=26.3681592039801, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=417, Percent_Identity=25.6594724220624, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=422, Percent_Identity=28.6729857819905, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=420, Percent_Identity=28.3333333333333, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=488, Percent_Identity=23.9754098360656, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221512776, Length=363, Percent_Identity=20.9366391184573, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666159, Length=363, Percent_Identity=20.9366391184573, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550968, Length=489, Percent_Identity=24.9488752556237, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI19921172, Length=489, Percent_Identity=24.9488752556237, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51365; Mature: 51365

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQVKVVADDQSPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVY
CCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCW
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
VCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRMAK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVDQVKVVADDQSPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTINLAGPSIIFVY
CCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLSVIILLLVLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFSLIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCW
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
VCMAFFVFVLVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRMAK
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]