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The map label for this gene is odhL [H]

Identifier: 218692339

GI number: 218692339

Start: 4731182

End: 4732423

Strand: Direct

Name: odhL [H]

Synonym: ECED1_4772

Alternate gene names: 218692339

Gene position: 4731182-4732423 (Clockwise)

Preceding gene: 218692338

Following gene: 218692340

Centisome position: 90.82

GC content: 53.06

Gene sequence:

>1242_bases
TTGCTGCAATCTTCCGAACTGTACGCGCAAGTGCAGCATGAGGCGAGCATTCATGGCGTTAATGTTGACGGCGTATCTTT
CAATGCAGCTGCGATGATTCAACGTAAAGACGCCATAGTAAGCCGCCTGACAATGGGCATCGGCTTGCTGTTTAAGAAAA
ATAAAGTGAAGTACCTGTGCGGCCTCGCAACGTTAGAACATGCTCGGGATGAGATTTGGCAATTACGTGTAAACGATCAA
CAAATCCGCGCCCGTAATGTGGTGATTGCAACAGGTTCTCAGCCGCGTCAACTGCCTGGCGTTACCATTGATAATCAGCA
AATTCTCGATAATCGCGGCGCCCTGGCGTTAACCGCTGTGCCGCCGCGTCTCGGTGTGATCGGCGCTGGCGTGATTGGCC
TTGAACTGGGGTCTGTGTGGAATCGGGTCGGTTCAGACGTCACGTTGCTGGAGATGGCGCCAACGTTCTTGCCTGCACTG
GAAGCTCGCCTGTCGAACGAAGTCCGTAAAGCAATGATTGCCAGTGGGATGAAAATGCAACTGGCAGTAGAGATTGAGGC
TATTGAACAACGGGATGACGGTGTGCATGTGCGCTGGCGGCAGGGTGAGAAGCGAGAAGAAAGCCGCTTCGATAAATTAA
TTCTTGCCATTGGACGTGTACCGCGACTTTCTGGTGTCGATCTCGTGCAACTCGGTCTTGAAGCCGACAACCGTGGCGGT
ATTGCCGTCGATAACTTATGCCGTACCGGGAAAGCCGGGCTGTGGGCAATTGGTGATGTCGTGCGAGGGCCGATGCTGGC
GCATAAAGCGATGGCTGAAGGTGTGGTAGTTGCGGATCAAATTGCCGGACTGGCGGTAGAGCCGATTAATTTTGCGCTGA
TCCCTTCGGTGATTTACACCCAACCGGAAGTTGCGTGGGTAGGGGAAAACGAGGCCTCACTGAAAGCCGCTGGCAGAGTC
TTTAACAAAGGAAATTCTCTGTTTGCCGGTAACGGTCGCGCCTTAGCATTAGGCCAGGAAGGTGGGCGTTGCACGTTATA
CAGCGATAAACACACTGACCGCGTACTTGGCGGAGCGATTGTTGGCCCGCAGGCATCGGAGCTGATCAATGAAATTGCGC
TGGCGATGACTTTTAGCGCCTCTGGCGAGGATATTGCCTGTGCGATCCATGCGCATCCGACCTTAAGCGAAGTCATCCAC
GAAGCAGCAATGGCCTTGAATAATAAAGCATTACACGGATAA

Upstream 100 bases:

>100_bases
TGGGCTTTCCGTAGTATGTATTGATGATGGTGTTAATGCACAGGGCGAACCTTCGCCGGGCGGTACGTGTCTCAATGTCG
GCTGTATTCCGTCAAAATCG

Downstream 100 bases:

>100_bases
CACATACCACTGAGGGAATATATGAATTTACATGAGTATCAGGCCAAATCGTTACTGGCTGGCATGGGGATGCCGTGTCC
AAAAGAGATAGCCATCCAAC

Product: putative dihydrolipoyl dehydrogenase, E3 component (lpd-like)

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MLQSSELYAQVQHEASIHGVNVDGVSFNAAAMIQRKDAIVSRLTMGIGLLFKKNKVKYLCGLATLEHARDEIWQLRVNDQ
QIRARNVVIATGSQPRQLPGVTIDNQQILDNRGALALTAVPPRLGVIGAGVIGLELGSVWNRVGSDVTLLEMAPTFLPAL
EARLSNEVRKAMIASGMKMQLAVEIEAIEQRDDGVHVRWRQGEKREESRFDKLILAIGRVPRLSGVDLVQLGLEADNRGG
IAVDNLCRTGKAGLWAIGDVVRGPMLAHKAMAEGVVVADQIAGLAVEPINFALIPSVIYTQPEVAWVGENEASLKAAGRV
FNKGNSLFAGNGRALALGQEGGRCTLYSDKHTDRVLGGAIVGPQASELINEIALAMTFSASGEDIACAIHAHPTLSEVIH
EAAMALNNKALHG

Sequences:

>Translated_413_residues
MLQSSELYAQVQHEASIHGVNVDGVSFNAAAMIQRKDAIVSRLTMGIGLLFKKNKVKYLCGLATLEHARDEIWQLRVNDQ
QIRARNVVIATGSQPRQLPGVTIDNQQILDNRGALALTAVPPRLGVIGAGVIGLELGSVWNRVGSDVTLLEMAPTFLPAL
EARLSNEVRKAMIASGMKMQLAVEIEAIEQRDDGVHVRWRQGEKREESRFDKLILAIGRVPRLSGVDLVQLGLEADNRGG
IAVDNLCRTGKAGLWAIGDVVRGPMLAHKAMAEGVVVADQIAGLAVEPINFALIPSVIYTQPEVAWVGENEASLKAAGRV
FNKGNSLFAGNGRALALGQEGGRCTLYSDKHTDRVLGGAIVGPQASELINEIALAMTFSASGEDIACAIHAHPTLSEVIH
EAAMALNNKALHG
>Mature_413_residues
MLQSSELYAQVQHEASIHGVNVDGVSFNAAAMIQRKDAIVSRLTMGIGLLFKKNKVKYLCGLATLEHARDEIWQLRVNDQ
QIRARNVVIATGSQPRQLPGVTIDNQQILDNRGALALTAVPPRLGVIGAGVIGLELGSVWNRVGSDVTLLEMAPTFLPAL
EARLSNEVRKAMIASGMKMQLAVEIEAIEQRDDGVHVRWRQGEKREESRFDKLILAIGRVPRLSGVDLVQLGLEADNRGG
IAVDNLCRTGKAGLWAIGDVVRGPMLAHKAMAEGVVVADQIAGLAVEPINFALIPSVIYTQPEVAWVGENEASLKAAGRV
FNKGNSLFAGNGRALALGQEGGRCTLYSDKHTDRVLGGAIVGPQASELINEIALAMTFSASGEDIACAIHAHPTLSEVIH
EAAMALNNKALHG

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransfer

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=416, Percent_Identity=40.1442307692308, Blast_Score=280, Evalue=1e-75,
Organism=Homo sapiens, GI50301238, Length=411, Percent_Identity=22.8710462287105, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI291045266, Length=392, Percent_Identity=25, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI22035672, Length=329, Percent_Identity=24.6200607902736, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI291045268, Length=384, Percent_Identity=23.6979166666667, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI33519430, Length=330, Percent_Identity=23.030303030303, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33519428, Length=330, Percent_Identity=23.030303030303, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33519426, Length=330, Percent_Identity=23.030303030303, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI148277065, Length=330, Percent_Identity=23.030303030303, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI148277071, Length=330, Percent_Identity=23.030303030303, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786307, Length=370, Percent_Identity=39.1891891891892, Blast_Score=238, Evalue=4e-64,
Organism=Escherichia coli, GI87082354, Length=381, Percent_Identity=27.0341207349081, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1789915, Length=402, Percent_Identity=25.3731343283582, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI87081717, Length=324, Percent_Identity=25.6172839506173, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI32565766, Length=415, Percent_Identity=39.5180722891566, Blast_Score=280, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI17557007, Length=325, Percent_Identity=26.4615384615385, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71983429, Length=403, Percent_Identity=25.0620347394541, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71983419, Length=403, Percent_Identity=25.0620347394541, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71982272, Length=338, Percent_Identity=25.1479289940828, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559934, Length=223, Percent_Identity=26.9058295964126, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=428, Percent_Identity=37.6168224299065, Blast_Score=273, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6325240, Length=364, Percent_Identity=28.8461538461538, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6325166, Length=412, Percent_Identity=24.7572815533981, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI21358499, Length=412, Percent_Identity=39.3203883495146, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24640553, Length=416, Percent_Identity=25, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24640549, Length=416, Percent_Identity=25, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24640551, Length=421, Percent_Identity=25.1781472684086, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI17737741, Length=416, Percent_Identity=22.3557692307692, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 44191; Mature: 44191

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSSELYAQVQHEASIHGVNVDGVSFNAAAMIQRKDAIVSRLTMGIGLLFKKNKVKYLC
CCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCEEEHH
GLATLEHARDEIWQLRVNDQQIRARNVVIATGSQPRQLPGVTIDNQQILDNRGALALTAV
HHHHHHHHHHHHEEEEECCCEEEEEEEEEECCCCCCCCCCEEECCHHHHCCCCCEEEEEC
PPRLGVIGAGVIGLELGSVWNRVGSDVTLLEMAPTFLPALEARLSNEVRKAMIASGMKMQ
CCCCCEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LAVEIEAIEQRDDGVHVRWRQGEKREESRFDKLILAIGRVPRLSGVDLVQLGLEADNRGG
EEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCC
IAVDNLCRTGKAGLWAIGDVVRGPMLAHKAMAEGVVVADQIAGLAVEPINFALIPSVIYT
EEHHHHHHCCCCCEEEHHHHHCCHHHHHHHHHCCEEEEHHHCCEEECCCCEEEECHHHCC
QPEVAWVGENEASLKAAGRVFNKGNSLFAGNGRALALGQEGGRCTLYSDKHTDRVLGGAI
CCCEEEECCCCHHHHHHHHHHCCCCEEEECCCCEEEEECCCCEEEEECCCCCCHHHCCEE
VGPQASELINEIALAMTFSASGEDIACAIHAHPTLSEVIHEAAMALNNKALHG
ECCCHHHHHHHHHHEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLQSSELYAQVQHEASIHGVNVDGVSFNAAAMIQRKDAIVSRLTMGIGLLFKKNKVKYLC
CCCCHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCEEEHH
GLATLEHARDEIWQLRVNDQQIRARNVVIATGSQPRQLPGVTIDNQQILDNRGALALTAV
HHHHHHHHHHHHEEEEECCCEEEEEEEEEECCCCCCCCCCEEECCHHHHCCCCCEEEEEC
PPRLGVIGAGVIGLELGSVWNRVGSDVTLLEMAPTFLPALEARLSNEVRKAMIASGMKMQ
CCCCCEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LAVEIEAIEQRDDGVHVRWRQGEKREESRFDKLILAIGRVPRLSGVDLVQLGLEADNRGG
EEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCC
IAVDNLCRTGKAGLWAIGDVVRGPMLAHKAMAEGVVVADQIAGLAVEPINFALIPSVIYT
EEHHHHHHCCCCCEEEHHHHHCCHHHHHHHHHCCEEEEHHHCCEEECCCCEEEECHHHCC
QPEVAWVGENEASLKAAGRVFNKGNSLFAGNGRALALGQEGGRCTLYSDKHTDRVLGGAI
CCCEEEECCCCHHHHHHHHHHCCCCEEEECCCCEEEEECCCCEEEEECCCCCCHHHCCEE
VGPQASELINEIALAMTFSASGEDIACAIHAHPTLSEVIHEAAMALNNKALHG
ECCCHHHHHHHHHHEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8867378 [H]