Click here to switch to the map view.

The map label for this gene is metA [H]

Identifier: 218692290

GI number: 218692290

Start: 4673564

End: 4674493

Strand: Direct

Name: metA [H]

Synonym: ECED1_4720

Alternate gene names: 218692290

Gene position: 4673564-4674493 (Clockwise)

Preceding gene: 218692288

Following gene: 218692291

Centisome position: 89.71

GC content: 50.32

Gene sequence:

>930_bases
ATGCCGATTCGTGTGCCGGACGAGCTACCCGCCGTCAATTTCTTGCGTGAAGAAAACGTCTTTGTGATGACAACTTCTCG
CGCGTCTGGTCAGGAAATTCGTCCGCTAAAGGTGCTTATCCTTAACCTGATGCCGAAGAAGATCGAAACTGAAAATCAGT
TTCTGCGCCTGCTTTCAAACTCACCTTTGCAGGTCGATATTCAGCTTTTGCGCATCGATTCCCGTGAATCGCGCAACACG
CCCGCAGAGCATCTGAATAACTTCTACTGTAACTTTGAAGATATTCAGGAACAAAACTTTGACGGTCTGATAGTTACCGG
CGCGCCGCTGGGCCTGGTGGAGTTTAATGATGTCGCTTACTGGCCGCAGATCAAACAGGTGCTGGAGTGGTCGAAAGATC
ACGTCACCTCGACGCTGTTTGTCTGCTGGGCTGTACAGGCCGCGCTCAATATCCTCTATGGTATTCCTAAGCAAACCCGC
ACCGACAAACTCTCTGGCGTTTACGAGCATCATATTCTCCATCCTCATGCGCTTCTGACGCGTGGCTTTGATGATTCATT
CCTGGCACCGCATTCGCGCTATGCTGACTTTCCGGCAGCGTTGATTCGTGATTATACCGATCTGGAAATTCTGGCAGAGA
CGGAAGAAGGGGATGCATATCTGTTTGCCAGCAAAGATAAGCGCATTGCCTTTGTGACGGGCCATCCCGAATATGATGCG
CAAACGCTGGCGCAGGAATATTTCCGCGATGTGGAAGCCGGGCTAGACCCGGATGTACCGTATAACTATTTCCCGCACAA
TGATCCGCAAAATACACCGCGAGCGAGCTGGCGTAGTCACGGTAATTTGCTGTTTACCAACTGGCTCAACTATTACGTCT
ACCAGATCACGCCATATGATCTACGGCACATGAATCCAACGCTGGATTAA

Upstream 100 bases:

>100_bases
TCACCTTCAACATGCAGGCTCGACATTGGTAAATTTTCTGGTTATCTTCAGCTATCTGGATGTCTAAACGTATAAGCGTA
TGTAGTGAGGTAATCAGGTT

Downstream 100 bases:

>100_bases
TCTTCTGTGATAGTCGATCGTTAAGCGATTCAGCACTTTACCTCAGGCACCTTCGGGTGCCTTTTTTATTTCCGAAACAC
ACCTCAGCAAGTGAATAAAT

Product: homoserine O-succinyltransferase

Products: NA

Alternate protein names: Homoserine O-transsuccinylase; HTS [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNT
PAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTR
TDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDA
QTLAQEYFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD

Sequences:

>Translated_309_residues
MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNT
PAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTR
TDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDA
QTLAQEYFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
>Mature_308_residues
PIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTP
AEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRT
DKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQ
TLAQEYFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD

Specific function: Methionine biosynthesis; HTS variant; first step. [C]

COG id: COG1897

COG function: function code E; Homoserine trans-succinylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HTS family [H]

Homologues:

Organism=Escherichia coli, GI1790443, Length=309, Percent_Identity=99.0291262135922, Blast_Score=637, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005697
- ProDom:   PD037892 [H]

Pfam domain/function: PF04204 HTS [H]

EC number: =2.3.1.46 [H]

Molecular weight: Translated: 35744; Mature: 35612

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSN
CCCCCCCCCCHHHHEECCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
SPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAY
CCCEEEEEEEEECCCCCCCCCHHHHHCEECCHHHHHHCCCCEEEEECCCCCEEEECCEEC
WPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHH
RGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDA
CCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCEEEEECCCCEEEEEECCCCCCH
QTLAQEYFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYD
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECEEEEEEECCHH
LRHMNPTLD
HHCCCCCCC
>Mature Secondary Structure 
PIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSN
CCCCCCCCCHHHHEECCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
SPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAY
CCCEEEEEEEEECCCCCCCCCHHHHHCEECCHHHHHHCCCCEEEEECCCCCEEEECCEEC
WPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHH
RGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDA
CCCCCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCCEEEEECCCCEEEEEECCCCCCH
QTLAQEYFRDVEAGLDPDVPYNYFPHNDPQNTPRASWRSHGNLLFTNWLNYYVYQITPYD
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEEECEEEEEEECCHH
LRHMNPTLD
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA