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The map label for this gene is ubiE [H]

Identifier: 218692127

GI number: 218692127

Start: 4475829

End: 4476584

Strand: Direct

Name: ubiE [H]

Synonym: ECED1_4537

Alternate gene names: 218692127

Gene position: 4475829-4476584 (Clockwise)

Preceding gene: 218692126

Following gene: 218692128

Centisome position: 85.92

GC content: 51.85

Gene sequence:

>756_bases
ATGGTGGATAAGTCACAAGAAACGACGCACTTTGGTTTTCAGACCGTCGCGAAGGAACAAAAAGCGGATATGGTCGCCCA
CGTTTTCCATTCCGTGGCATCAAAATACGATGTCATGAATGATTTGATGTCATTCGGTATTCATCGTTTGTGGAAGCGAT
TCACGATTGATTGCAGCGGCGTACGCCGTGGGCAGACCGTGCTGGATCTGGCTGGTGGCACCGGCGACCTGACAGCGAAA
TTCTCTCGCCTGGTCGGAGAAACTGGCAAAGTGGTCCTTGCTGATATCAATGAATCCATGCTCAAAATGGGCCGCGAGAA
GCTGCGTAATATCGGTGTGATTGGCAACGTTGAGTATGTTCAGGCGAACGCTGAGGCGCTGCCGTTCCCGGATAACACCT
TTGATTGCATCACCATTTCGTTTGGTCTGCGTAACGTCACCGACAAAGATAAAGCACTGCGTTCAATGTATCGCGTGCTG
AAACCCGGCGGCCGCCTGCTGGTACTTGAGTTCTCGAAGCCAATTATCGAGCCGCTGAGCAAAGCCTATGATGCATACTC
CTTCCATGTGCTGCCGCGTATTGGCTCACTGGTCGCGAACGACGCCGACAGCTACCGTTATCTGGCAGAATCCATCCGTA
TGCATCCCGATCAGGATACCCTGAAAACCATGATGCAGGATGCCGGATTCGAAAGTGTCGACTACTACAATCTGACGGCA
GGGGTTGTGGCGCTGCATCGTGGTTATAAGTTCTGA

Upstream 100 bases:

>100_bases
CGCTAGCCCATTGGGGGTAGTTAAGCCGGGTAGAAATCTAGGGCATCGACGCCCAATCTGTTACACTTCTGGAACAATTT
TTTGATGAGCAGGCATTGAG

Downstream 100 bases:

>100_bases
CAGGAGACCGGAAATGCCTTTTAAACCTTTAGTGACGGCAGGAATTGAAAGTCTGCTCAACACCTTCCTGTATCGCTCAC
CCGCGCTGAAAACGGCCCGC

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAK
FSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVL
KPGGRLLVLEFSKPIIEPLSKAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKTMMQDAGFESVDYYNLTA
GVVALHRGYKF

Sequences:

>Translated_251_residues
MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAK
FSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVL
KPGGRLLVLEFSKPIIEPLSKAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKTMMQDAGFESVDYYNLTA
GVVALHRGYKF
>Mature_251_residues
MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAK
FSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVL
KPGGRLLVLEFSKPIIEPLSKAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKTMMQDAGFESVDYYNLTA
GVVALHRGYKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=282, Percent_Identity=43.6170212765958, Blast_Score=234, Evalue=4e-62,
Organism=Escherichia coli, GI48994983, Length=251, Percent_Identity=99.601593625498, Blast_Score=520, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17557039, Length=247, Percent_Identity=47.3684210526316, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6323526, Length=265, Percent_Identity=44.9056603773585, Blast_Score=191, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24641702, Length=263, Percent_Identity=44.8669201520913, Blast_Score=239, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28104; Mature: 28104

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VRRGQTVLDLAGGTGDLTAKFSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYV
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEE
QANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVLKPGGRLLVLEFSKPIIEPLS
ECCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHH
KAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKTMMQDAGFESVDYYNLTA
HHHHHHHEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHH
GVVALHRGYKF
HHHHHHCCCCC
>Mature Secondary Structure
MVDKSQETTHFGFQTVAKEQKADMVAHVFHSVASKYDVMNDLMSFGIHRLWKRFTIDCSG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VRRGQTVLDLAGGTGDLTAKFSRLVGETGKVVLADINESMLKMGREKLRNIGVIGNVEYV
CCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCEE
QANAEALPFPDNTFDCITISFGLRNVTDKDKALRSMYRVLKPGGRLLVLEFSKPIIEPLS
ECCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHH
KAYDAYSFHVLPRIGSLVANDADSYRYLAESIRMHPDQDTLKTMMQDAGFESVDYYNLTA
HHHHHHHEEHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHH
GVVALHRGYKF
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA