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The map label for this gene is ilvY [H]

Identifier: 218692053

GI number: 218692053

Start: 4393676

End: 4394650

Strand: Reverse

Name: ilvY [H]

Synonym: ECED1_4459

Alternate gene names: 218692053

Gene position: 4394650-4393676 (Counterclockwise)

Preceding gene: 218692055

Following gene: 218692046

Centisome position: 84.36

GC content: 56.21

Gene sequence:

>975_bases
ATGACAGGAAATTTATTGCGGAAATTGATATATTCACAACGTCACATTGCAATTTTTGCAACGTCAACATTGAGGGCTGC
GCCATTGGATTTACGCGATCTGAAAACCTTCCTGCATCTGGCGGAAAGCCGCCATTTTGGCCGCAGCGCGCGGGCAATGC
ACGTTAGCCCGTCCACGCTCTCTCGGCAGATTCAGCGCCTGGAAGACGATCTCGGTCAGCCGCTGTTTGTGCGCGATAAC
CGCACGGTAACGCTAACCGAAGCAGGCGAAGAACTGCGCGTTTTCGCCCAGCAAACGCTGTTGCAGTATCAACAGCTGCG
CCACACCATCGATCAGCAAGGACCGTCGCTCTCTGGCGAATTACATATCTTCTGCTCGGTGACCGCTGCCTACAGCCATC
TGCCGCCGATTCTCGATCGCTTCCGCGCGGAACACCCGTCGGTGGAGATTAAACTCACGACTGGTGATGCGGCAGATGCG
ATGGAAAAGGTAGTCACTGGCGAAGCGGATCTGGCGATTGCCGGGAAACCGGAGACTCTGCCCGGCGCAGTGGCGTTTTC
GATGCTGGAGAATCTGGCAGTAGTGCTGATTGCCCCCGCGCTACCCTGCCCGGTGCGTAACCAAGTTTCGGCAGAGAAGC
CGGACTGGTCTACAGTGCCGTTTATCATGGCCGATCAGGGACCGGTGCGCCGGCGCATTGAACTGTGGTTTCGACGCAAC
AAAATCAGCAACCCGATGATTTACGCCACGGTCGGCGGGCATGAAGCGATGGTGTCGATGGTAGCGCTCGGCTGTGGCGT
GGCCTTGTTGCCGGAAGTGGTGCTGGAAAACAGCCCGGAACCAGTGCGTAACCGCGTGATGATTTTAGAGCGCAGTGATG
AAAAAACGCCGTTTGAACTGGGCGTGTGTGTGCAGAAAAAGCGGCTACATGAGCCGCTGATTGAGGCGTTCTGGAAGATT
TTGCCGAACCACTAA

Upstream 100 bases:

>100_bases
TGGCGCAGATTCAGTGTATTGAAGTAGTTAGCCATGGTGATTCCTCGTGATGTTGTGCTTCTTATTGTTCGGTTCGCGTT
TGCGAGATTGAATTCACTAT

Downstream 100 bases:

>100_bases
CCCGCCAAAAAGAACCTGAACGCCGGGTTATTGGTTTCGTCGTGGCAATCGTAGCCCAGTTCATTCAGCCGGGTTTCAAA
ATCCGGTTCATGATCGCCAA

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEDDLGQPLFVRDN
RTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADA
MEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQVSAEKPDWSTVPFIMADQGPVRRRIELWFRRN
KISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCVQKKRLHEPLIEAFWKI
LPNH

Sequences:

>Translated_324_residues
MTGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEDDLGQPLFVRDN
RTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADA
MEKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQVSAEKPDWSTVPFIMADQGPVRRRIELWFRRN
KISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCVQKKRLHEPLIEAFWKI
LPNH
>Mature_323_residues
TGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTLSRQIQRLEDDLGQPLFVRDNR
TVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGELHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAM
EKVVTGEADLAIAGKPETLPGAVAFSMLENLAVVLIAPALPCPVRNQVSAEKPDWSTVPFIMADQGPVRRRIELWFRRNK
ISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFELGVCVQKKRLHEPLIEAFWKIL
PNH

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=296, Percent_Identity=98.6486486486486, Blast_Score=604, Evalue=1e-174,
Organism=Escherichia coli, GI1790399, Length=261, Percent_Identity=29.5019157088123, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788297, Length=250, Percent_Identity=28.4, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788887, Length=253, Percent_Identity=28.8537549407115, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI157672245, Length=179, Percent_Identity=32.4022346368715, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787806, Length=256, Percent_Identity=25, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI145693105, Length=167, Percent_Identity=28.7425149700599, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=26.4227642276423, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI2367136, Length=254, Percent_Identity=27.5590551181102, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787601, Length=148, Percent_Identity=27.7027027027027, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790262, Length=299, Percent_Identity=25.4180602006689, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788481, Length=249, Percent_Identity=24.8995983935743, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788296, Length=225, Percent_Identity=29.7777777777778, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788748, Length=298, Percent_Identity=23.489932885906, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787530, Length=249, Percent_Identity=23.2931726907631, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789440, Length=176, Percent_Identity=26.7045454545455, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994962, Length=82, Percent_Identity=37.8048780487805, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788706, Length=143, Percent_Identity=30.7692307692308, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI145693193, Length=123, Percent_Identity=34.1463414634146, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789173, Length=259, Percent_Identity=25.8687258687259, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36170; Mature: 36039

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTL
CCHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHH
SRQIQRLEDDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGE
HHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETL
EEEEEEEHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCEEECCCCCCC
PGAVAFSMLENLAVVLIAPALPCPVRNQVSAEKPDWSTVPFIMADQGPVRRRIELWFRRN
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHC
KISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFEL
CCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHH
GVCVQKKRLHEPLIEAFWKILPNH
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TGNLLRKLIYSQRHIAIFATSTLRAAPLDLRDLKTFLHLAESRHFGRSARAMHVSPSTL
CHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHH
SRQIQRLEDDLGQPLFVRDNRTVTLTEAGEELRVFAQQTLLQYQQLRHTIDQQGPSLSGE
HHHHHHHHHHCCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
LHIFCSVTAAYSHLPPILDRFRAEHPSVEIKLTTGDAADAMEKVVTGEADLAIAGKPETL
EEEEEEEHHHHHCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCEEECCCCCCC
PGAVAFSMLENLAVVLIAPALPCPVRNQVSAEKPDWSTVPFIMADQGPVRRRIELWFRRN
HHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHC
KISNPMIYATVGGHEAMVSMVALGCGVALLPEVVLENSPEPVRNRVMILERSDEKTPFEL
CCCCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHH
GVCVQKKRLHEPLIEAFWKILPNH
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]