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The map label for this gene is dfp [H]

Identifier: 218691923

GI number: 218691923

Start: 4246895

End: 4248115

Strand: Direct

Name: dfp [H]

Synonym: ECED1_4323

Alternate gene names: 218691923

Gene position: 4246895-4248115 (Clockwise)

Preceding gene: 218691918

Following gene: 218691924

Centisome position: 81.52

GC content: 53.48

Gene sequence:

>1221_bases
ATGAGCCTGGCCGGTAAAAAAATCGTTCTCGGCGTTAGCGGCGGTATTGCTGCCTATAAAACCCCTGAACTGGTGCGTCG
TTTGCGCGATCGCGGGGCCGATGTCCGCGTAGCCATGACCGAAGCGGCAAAAGCCTTTATCACCCCACTTAGCTTGCAGG
CGGTTTCTGGTTATCCCGTTTCCGACAGTCTGCTGGACCCGGCAGCCGAAGCCGCTATGGGCCATATTGAGCTGGGTAAA
TGGGCTGATTTAGTGATTCTCGCCCCTGCCACGGCAGATTTAATTGCCCGTGTTGCTGCCGGAATGGCGAATGACCTGGT
ATCGACGATTTGTCTGGCTACACCTGCGCCTGTAGCCGTGCTCCCCGCCATGAACCAGCAGATGTACCGTGCCGCTGCCA
CGCAGCATAATTTAGAGGTGCTTGCCTCGCGTGGTTTGCTCATCTGGGGGCCAGACAGCGGCAGTCAGGCTTGTGGTGAT
ATCGGCCCAGGACGAATGCTCGATCCGTTAACCATTGTGGATATGGCGGTAGCGCATTTTTCGCCCGTCAACGACCTGAA
ACATCTGAACATTATGATTACCGCCGGTCCGACGCGTGAACCGCTCGATCCCGTGCGTTATATCTCTAATCACAGCTCCG
GCAAGATGGGTTTTGCTATCGCCGCCGCCGCAGCCCGTCGTGGCGCGAACGTCACGCTGGTATCAGGTCCGGTTTCACTA
CCGACGCCACCGTTTGTTAACCGTGTTGATGTGATGACCGCGCTGGAAATGGAAGCCGCCGTGAATGCTTCTGTACAGCA
GCAAAATATTTTTATCGGTTGCGCCGCCGTGGCGGATTATCGCGCAGCTACCGTGGCCCCAGAAAAAATCAAAAAGCAGG
CCACGCAGGGTGATGAATTAACAATAAAAATGGTTAAAAACCCCGATATCGTCGCAGGCGTTGCCGCACTAAAAGACCAT
CGACCCTACGTCGTTGGATTTGCCGCCGAAACAAATAATGTGGAAGAATACGCCCGGCAAAAACGTATCCGTAAAAACCT
TGATCTGATCTGCGCGAACGATGTTTCCCAGCCAACTCAAGGATTTAACAGCGACAACAACGCATTACACCTTTTCTGGC
AGGACGGAGATAAAGTCTTACCGCTTGAGCGCAAAGAGCTCCTTGGCCAATTATTACTCGACGAGATCGTGACCCGTTAT
GATGAAAAAAATCGACGTTAA

Upstream 100 bases:

>100_bases
GGAAAGCGCCTCGCAAAGTGAATCTCAGGTGAAGGCACGACAACAAAAGTATTGTGATAAAATCGCCAACTTCTGGTGTC
ACCCAACAGGAAAAATCATC

Downstream 100 bases:

>100_bases
GATTCTGGACCCGCGCGTTGGGAAGGAATTTCCGCTCCCGACTTATGCCACCTCTGGCTCTGCCGGACTTGACCTGCGTG
CCTGTCTCGACGACGCCGTA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSLAGKKIVLGVSGGIAAYKTPELVRRLRDRGADVRVAMTEAAKAFITPLSLQAVSGYPVSDSLLDPAAEAAMGHIELGK
WADLVILAPATADLIARVAAGMANDLVSTICLATPAPVAVLPAMNQQMYRAAATQHNLEVLASRGLLIWGPDSGSQACGD
IGPGRMLDPLTIVDMAVAHFSPVNDLKHLNIMITAGPTREPLDPVRYISNHSSGKMGFAIAAAAARRGANVTLVSGPVSL
PTPPFVNRVDVMTALEMEAAVNASVQQQNIFIGCAAVADYRAATVAPEKIKKQATQGDELTIKMVKNPDIVAGVAALKDH
RPYVVGFAAETNNVEEYARQKRIRKNLDLICANDVSQPTQGFNSDNNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRY
DEKNRR

Sequences:

>Translated_406_residues
MSLAGKKIVLGVSGGIAAYKTPELVRRLRDRGADVRVAMTEAAKAFITPLSLQAVSGYPVSDSLLDPAAEAAMGHIELGK
WADLVILAPATADLIARVAAGMANDLVSTICLATPAPVAVLPAMNQQMYRAAATQHNLEVLASRGLLIWGPDSGSQACGD
IGPGRMLDPLTIVDMAVAHFSPVNDLKHLNIMITAGPTREPLDPVRYISNHSSGKMGFAIAAAAARRGANVTLVSGPVSL
PTPPFVNRVDVMTALEMEAAVNASVQQQNIFIGCAAVADYRAATVAPEKIKKQATQGDELTIKMVKNPDIVAGVAALKDH
RPYVVGFAAETNNVEEYARQKRIRKNLDLICANDVSQPTQGFNSDNNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRY
DEKNRR
>Mature_405_residues
SLAGKKIVLGVSGGIAAYKTPELVRRLRDRGADVRVAMTEAAKAFITPLSLQAVSGYPVSDSLLDPAAEAAMGHIELGKW
ADLVILAPATADLIARVAAGMANDLVSTICLATPAPVAVLPAMNQQMYRAAATQHNLEVLASRGLLIWGPDSGSQACGDI
GPGRMLDPLTIVDMAVAHFSPVNDLKHLNIMITAGPTREPLDPVRYISNHSSGKMGFAIAAAAARRGANVTLVSGPVSLP
TPPFVNRVDVMTALEMEAAVNASVQQQNIFIGCAAVADYRAATVAPEKIKKQATQGDELTIKMVKNPDIVAGVAALKDHR
PYVVGFAAETNNVEEYARQKRIRKNLDLICANDVSQPTQGFNSDNNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRYD
EKNRR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=175, Percent_Identity=32.5714285714286, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI87082301, Length=406, Percent_Identity=99.7536945812808, Blast_Score=827, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17560194, Length=191, Percent_Identity=30.8900523560209, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322762, Length=185, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24657262, Length=192, Percent_Identity=30.2083333333333, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43425; Mature: 43293

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAGKKIVLGVSGGIAAYKTPELVRRLRDRGADVRVAMTEAAKAFITPLSLQAVSGYPV
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCEEEEECCCCC
SDSLLDPAAEAAMGHIELGKWADLVILAPATADLIARVAAGMANDLVSTICLATPAPVAV
CHHHHCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LPAMNQQMYRAAATQHNLEVLASRGLLIWGPDSGSQACGDIGPGRMLDPLTIVDMAVAHF
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
SPVNDLKHLNIMITAGPTREPLDPVRYISNHSSGKMGFAIAAAAARRGANVTLVSGPVSL
CCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCC
PTPPFVNRVDVMTALEMEAAVNASVQQQNIFIGCAAVADYRAATVAPEKIKKQATQGDEL
CCCCCCCHHHHHHHHHHHHHHCCCEECCEEEEEEEHHHCCHHHHCCHHHHHHHCCCCCCE
TIKMVKNPDIVAGVAALKDHRPYVVGFAAETNNVEEYARQKRIRKNLDLICANDVSQPTQ
EEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCC
GFNSDNNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRYDEKNRR
CCCCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLAGKKIVLGVSGGIAAYKTPELVRRLRDRGADVRVAMTEAAKAFITPLSLQAVSGYPV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCEEEEECCCCC
SDSLLDPAAEAAMGHIELGKWADLVILAPATADLIARVAAGMANDLVSTICLATPAPVAV
CHHHHCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LPAMNQQMYRAAATQHNLEVLASRGLLIWGPDSGSQACGDIGPGRMLDPLTIVDMAVAHF
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
SPVNDLKHLNIMITAGPTREPLDPVRYISNHSSGKMGFAIAAAAARRGANVTLVSGPVSL
CCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEECCCCC
PTPPFVNRVDVMTALEMEAAVNASVQQQNIFIGCAAVADYRAATVAPEKIKKQATQGDEL
CCCCCCCHHHHHHHHHHHHHHCCCEECCEEEEEEEHHHCCHHHHCCHHHHHHHCCCCCCE
TIKMVKNPDIVAGVAALKDHRPYVVGFAAETNNVEEYARQKRIRKNLDLICANDVSQPTQ
EEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCC
GFNSDNNALHLFWQDGDKVLPLERKELLGQLLLDEIVTRYDEKNRR
CCCCCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]