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The map label for this gene is glpG

Identifier: 218691699

GI number: 218691699

Start: 3992434

End: 3993264

Strand: Reverse

Name: glpG

Synonym: ECED1_4084

Alternate gene names: 218691699

Gene position: 3993264-3992434 (Counterclockwise)

Preceding gene: 218691700

Following gene: 218691698

Centisome position: 76.65

GC content: 53.79

Gene sequence:

>831_bases
ATGTTGATGATTACCTCTTTTGCTAACCCCCGCGTGGCGCAGGCGTTTGTTGATTACATGGCGACGCAGGGTGTTATCCT
CACGATTCAACAACATAACCAAAGCGATGTCTGGCTGGCGGATGAGTCCCAGGCCGAACGCGTGCGGGCGGAGCTGGCGC
GTTTTCTCGGAAACCCGGCAGATCCGCGTTATCTGGCGGCCAGTTGGCAGTCCGGTCATACCGACAGTGGCCTGCATTAT
CGCCGTTATCCTTTCTTTGCTGCCTTGCGTGAACGCGCAGGTCCGGTAACCTGGGTGATGATGATCGCCTGCGTGGTGGT
GTTTATCGCCATGCAAATTCTCGGCGATCAAGAAGTGATGTTATGGCTGGCCTGGCCATTCGATCCGACGCTGAAATTTG
AGTTCTGGCGTTACTTCACCCACGCGTTAATGCACTTCTCGCTGATGCATATCCTCTTTAACCTGCTCTGGTGGTGGTAT
CTCGGCGGTGCGGTGGAAAAACGCCTCGGTAGCGGTAAGCTAATTGTCATTACTCTCATTAGCGCCCTGTTAAGCGGCTA
TGTGCAGCAAAAATTCAGCGGGCCGTGGTTTGGCGGGCTTTCTGGCGTGGTGTATGCGCTGATGGGCTACGTCTGGCTAC
GTGGCGAACGCGATCCGCAAAGTGGCATTTACCTGCAACGTGGGTTAATTATCTTTGCGTTGATCTGGATTGTCGCCGGA
TGGTTTGATTTGTTTGGGATGTCGATGGCGAACGGAGCACACATCGCCGGGTTAGCCGTGGGTTTAGCGATGGCTTTTGT
TGATTCGCTCAATGCGCGAAAACGAAAATAA

Upstream 100 bases:

>100_bases
GCGGCTTTGAAGCCTGGCAGCGCCAGTTTCCCGCAGAGGTGGCGTACGGCGCGTAACGCTTTATACTGTCCCCTTTTGTG
TGGAATAAGCGACAGCAACG

Downstream 100 bases:

>100_bases
TTCCAGGGATTTATCAATGAAACAAACACAACGTCACAACGGTATTATCGAACTGGTTAAACAGCAGGGTTATGTCAGCA
CCGAGGAGCTGGTAGAGCAT

Product: intramembrane serine protease GlpG

Products: NA

Alternate protein names: Intramembrane serine protease

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLGNPADPRYLAASWQSGHTDSGLHY
RRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWY
LGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK

Sequences:

>Translated_276_residues
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLGNPADPRYLAASWQSGHTDSGLHY
RRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWY
LGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
>Mature_276_residues
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLGNPADPRYLAASWQSGHTDSGLHY
RRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWY
LGGAVEKRLGSGKLIVITLISALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family

Homologues:

Organism=Escherichia coli, GI48994938, Length=276, Percent_Identity=98.9130434782609, Blast_Score=554, Evalue=1e-159,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLPG_ECO81 (B7N156)

Other databases:

- EMBL:   CU928162
- RefSeq:   YP_002399911.1
- ProteinModelPortal:   B7N156
- EnsemblBacteria:   EBESCT00000143622
- GeneID:   7142975
- GenomeReviews:   CU928162_GR
- GeneTree:   EBGT00050000011644
- HOGENOM:   HBG495087
- OMA:   WYLGGKI
- ProtClustDB:   PRK10907
- BioCyc:   ECOL585397:ECED1_4084-MONOMER
- HAMAP:   MF_01594
- InterPro:   IPR022732
- InterPro:   IPR002610
- InterPro:   IPR022764
- PANTHER:   PTHR22936

Pfam domain/function: PF12122 DUF3582; PF01694 Rhomboid

EC number: =3.4.21.105

Molecular weight: Translated: 31309; Mature: 31309

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: ACT_SITE 201-201 ACT_SITE 254-254

Signals:

None

Transmembrane regions:

HASH(0x24b82cb8)-; HASH(0x1f1eae8c)-; HASH(0x24cd6868)-; HASH(0x2478d2b8)-; HASH(0x23c5b1c0)-; HASH(0x24d8d690)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLGNPA
CEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCC
DPRYLAASWQSGHTDSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVM
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEE
LWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MLMITSFANPRVAQAFVDYMATQGVILTIQQHNQSDVWLADESQAERVRAELARFLGNPA
CEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCCC
DPRYLAASWQSGHTDSGLHYRRYPFFAALRERAGPVTWVMMIACVVVFIAMQILGDQEVM
CCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEE
LWLAWPFDPTLKFEFWRYFTHALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SALLSGYVQQKFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
WFDLFGMSMANGAHIAGLAVGLAMAFVDSLNARKRK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA