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The map label for this gene is glpR [H]

Identifier: 218691698

GI number: 218691698

Start: 3991659

End: 3992417

Strand: Reverse

Name: glpR [H]

Synonym: ECED1_4083

Alternate gene names: 218691698

Gene position: 3992417-3991659 (Counterclockwise)

Preceding gene: 218691699

Following gene: 218691696

Centisome position: 76.64

GC content: 54.02

Gene sequence:

>759_bases
ATGAAACAAACACAACGTCACAACGGTATTATCGAACTGGTTAAACAGCAGGGTTATGTCAGCACCGAGGAGCTGGTAGA
GCATTTCTCCGTTAGCCCGCAGACTATTCGCCGCGATCTCAACGAGCTGGCAGAGCAAAACCTGATCCTGCGCCATCATG
GCGGTGCGGCGCTGCCTTCCAGTTCGGTTAACACGCCGTGGCACGATCGCAAGGCCACCCAGACCGAAGAAAAAGAGCGC
ATCGCCCGCAAAGTGGCGGAGCAAATTCCCAATGGCTCGACGCTGTTTATCGATATCGGCACCACGCCGGAAGCGGTGGC
GCACGCGCTGCTTAATCACAGCAATTTGCGCATTGTGACCAACAATCTCAACGTCGCTAACACGCTGATGGTAAAAGAGG
ATTTCCGTATCATTCTTGCCGGTGGTGAATTGCGTAGCCGTGATGGCGGGATCATTGGCGAAGCAACGCTCGATTTTATC
TCCCAGTTCCGCCTCGATTTCGGCATTCTGGGGATAAGCGGCATCGATAGCGACGGCTCGCTACTGGAGTTCGATTACCA
CGAAGTTCGCACCAAACGCGCCATCATTGAGAACTCGCGCCACGTTATGCTGGTTGTCGACCACTCAAAATTTGGCCGTA
ACGCAATGGTCAATATGGGTAGCATCAGCATGGTCGATGCTGTCTACACCGACACGATGCCGCCTGCGAGCGTGATGCAG
GTGCTGAAGGACCATCATATTCAACTGGAGCTGTGCTGA

Upstream 100 bases:

>100_bases
GCGAACGGAGCACACATCGCCGGGTTAGCCGTGGGTTTAGCGATGGCTTTTGTTGATTCGCTCAATGCGCGAAAACGAAA
ATAATTCCAGGGATTTATCA

Downstream 100 bases:

>100_bases
TCCTGCATTGCTTCCCATGTCAGACCAAAACGCGCCAGGTATTTGCGTAGCCGATCCGCGTCATTGACGCTGGCTTTACC
CTGGCGCGAAATGTCAAACA

Product: DNA-binding transcriptional repressor GlpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSSSVNTPWHDRKATQTEEKER
IARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDFI
SQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDTMPPASVMQ
VLKDHHIQLELC

Sequences:

>Translated_252_residues
MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSSSVNTPWHDRKATQTEEKER
IARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDFI
SQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDTMPPASVMQ
VLKDHHIQLELC
>Mature_252_residues
MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPSSSVNTPWHDRKATQTEEKER
IARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDFI
SQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDTMPPASVMQ
VLKDHHIQLELC

Specific function: Repressor of the glycerol-3-phosphate regulon [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=252, Percent_Identity=98.4126984126984, Blast_Score=509, Evalue=1e-146,
Organism=Escherichia coli, GI87082344, Length=246, Percent_Identity=45.1219512195122, Blast_Score=234, Evalue=4e-63,
Organism=Escherichia coli, GI1788069, Length=251, Percent_Identity=29.8804780876494, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789519, Length=251, Percent_Identity=28.6852589641434, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1789059, Length=251, Percent_Identity=29.4820717131474, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI226510968, Length=250, Percent_Identity=30.4, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789170, Length=240, Percent_Identity=27.9166666666667, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787063, Length=253, Percent_Identity=26.8774703557312, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790753, Length=253, Percent_Identity=24.1106719367589, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787540, Length=234, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790635, Length=254, Percent_Identity=24.0157480314961, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28111; Mature: 28111

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPS
CCCCCHHCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCCC
SSVNTPWHDRKATQTEEKERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEE
NNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDFISQFRLDFGILGISGIDSDGS
CCCCEEEEEEEECCCEEEEECCCEECCCCCEEHHHHHHHHHHHHHHHEEEEEECCCCCCC
LLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDTMPPASVMQ
EEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCHHHHHHHHHCCCCHHHHHH
VLKDHHIQLELC
HHHCCCEEEEEC
>Mature Secondary Structure
MKQTQRHNGIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNELAEQNLILRHHGGAALPS
CCCCCHHCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCCCCCC
SSVNTPWHDRKATQTEEKERIARKVAEQIPNGSTLFIDIGTTPEAVAHALLNHSNLRIVT
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCCEEEEE
NNLNVANTLMVKEDFRIILAGGELRSRDGGIIGEATLDFISQFRLDFGILGISGIDSDGS
CCCCEEEEEEEECCCEEEEECCCEECCCCCEEHHHHHHHHHHHHHHHEEEEEECCCCCCC
LLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDTMPPASVMQ
EEEEHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECCCHHHHHHHHHCCCCHHHHHH
VLKDHHIQLELC
HHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8955387; 3045764; 9278503 [H]