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The map label for this gene is argD [H]

Identifier: 218691641

GI number: 218691641

Start: 3926380

End: 3927600

Strand: Reverse

Name: argD [H]

Synonym: ECED1_4023

Alternate gene names: 218691641

Gene position: 3927600-3926380 (Counterclockwise)

Preceding gene: 218691642

Following gene: 218691637

Centisome position: 75.39

GC content: 54.3

Gene sequence:

>1221_bases
ATGGCAATTGAACAAACAGCAATTACACGCGCGACTTTCGATGAAGTGATTCTGCCGATTTATGCTCCGGCAGAGTTTAT
TCCGGTAAAAGGTCAGGGCAGCCGAATCTGGGATCAACAGGGCAAGGAGTATGTCGATTTCGCGGGTGGCATTGCAGTTA
CGGCGTTGGGCCATTGCCATCCTGCGCTGGTGAACGCGTTAAAAACCCAGGGCGAAACTCTGTGGCATATTAGTAACGTT
TTCACCAATGAGCCGGCGCTGCGTCTTGGCCGTAAACTGATTGAGGCAACGTTTGCCGAACGCGTGGTGTTTATGAACTC
CGGCACGGAAGCTAACGAAACCGCCTTTAAACTGGCACGCCATTACGCCTGTGTGCGTCATAGCCCGTTCAAAACCAAAA
TTATTGCCTTCCATAACGCTTTTCATGGTCGCTCGCTGTTTACCGTTTCGGTGGGTGGGCAGCCAAAATATTCCGACGGC
TTTGGGCCAAAACCGGCAGACATCATCCACGTGCCTTTTAACGAGCTTCACGCAGTAAAAGCCGTGATGGATGACCATAC
CTGTGCGGTGGTGGTTGAGCCGATTCAGGGCGAGGGCGGCGTGACGGCAGCGACGCCAGAGTTTTTGCAGGGCTTGCGCG
AGCTGTGCGATCAACATCAGGCATTATTGGTGTTTGATGAAGTGCAGTGCGGGATGGGGCGGATCGGCGATCTGTTTGCT
TATATGCACTACGGCGTGACGCCGGATATTCTGACCTCTGCGAAAGCGCTAGGTGGCGGCTTCCCGGTTAGCGCCATGCT
GACCACGGCGGAGATTGCTTCCGCGTTTCATCCTGGTTCTCACGGTTCCACCTACGGCGGTAATCCTCTGGCCTGTGCAG
TAGCGGGCGCAGCGTTTGATATCATCAATACCCCTGAAGTGCTGGAAGGTATTCAGGCGAAACGCCAGCGTTTTGTTGAC
CATTTGCAGAAGATCGATCAGCAGTACGATGTGTTTAGCGATATTCGCGGTATGGGGCTGTTGATTGGCGCAGAGCTGAA
ACCACAGTACAAAGGTCGGGCGCGTGATTTCCTGTATGCGGGTGCAGAGGAAGGCGTAATGGTGCTGAATGCCGGGCCTG
ATGTGATGCGTTTTGCGCCGTCGCTGGTGGTGGAAGATGCGGATATCGATGAAGGGATGCATCGTTTCGCCCACGCGGTG
GCGAAGGTGATTGGGGCGTAA

Upstream 100 bases:

>100_bases
TTTCTGCATCGCTGATTTCTGATTGCCATTCAGTGATTTTTTATGCATATTTTGTGATTATAATTTCATATTTATTTATG
CGTAACAGGGTGATCATGAG

Downstream 100 bases:

>100_bases
ATAAGACGCGTCAGGCAAAAGATGTCGGATGCGGCGTGAACACCTCATCCGATGGTTTAGCCTGTATTACGCCTTCGAAT
CCCGCAACTTGCGACTCAGC

Product: bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT; DapATase; Succinyldiaminopimelate transferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDG
FGPKPADIIHVPFNELHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRIGDLFA
YMHYGVTPDILTSAKALGGGFPVSAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEEGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAV
AKVIGA

Sequences:

>Translated_406_residues
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNV
FTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDG
FGPKPADIIHVPFNELHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRIGDLFA
YMHYGVTPDILTSAKALGGGFPVSAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVD
HLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEEGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAV
AKVIGA
>Mature_405_residues
AIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCHPALVNALKTQGETLWHISNVF
TNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGF
GPKPADIIHVPFNELHAVKAVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRIGDLFAY
MHYGVTPDILTSAKALGGGFPVSAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFDIINTPEVLEGIQAKRQRFVDH
LQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYAGAEEGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAVA
KVIGA

Specific function: Involved in both the arginine and lysine biosynthetic pathways [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=378, Percent_Identity=36.7724867724868, Blast_Score=238, Evalue=9e-63,
Organism=Homo sapiens, GI284507298, Length=294, Percent_Identity=38.4353741496599, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI13994255, Length=425, Percent_Identity=28.9411764705882, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI37574042, Length=401, Percent_Identity=31.1720698254364, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI226442709, Length=374, Percent_Identity=31.5508021390374, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI226442705, Length=401, Percent_Identity=29.925187032419, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI24119277, Length=393, Percent_Identity=27.2264631043257, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI188536080, Length=419, Percent_Identity=23.3890214797136, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679950, Length=419, Percent_Identity=23.3890214797136, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI38679946, Length=419, Percent_Identity=23.3890214797136, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=98.5221674876847, Blast_Score=828, Evalue=0.0,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=60.2040816326531, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1789016, Length=413, Percent_Identity=35.3510895883777, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=32.6732673267327, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI145693181, Length=330, Percent_Identity=36.0606060606061, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1786349, Length=317, Percent_Identity=31.8611987381703, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786991, Length=299, Percent_Identity=33.1103678929766, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=375, Percent_Identity=36.5333333333333, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=28.175519630485, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI25144274, Length=260, Percent_Identity=37.6923076923077, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=420, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=438, Percent_Identity=26.2557077625571, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71981843, Length=164, Percent_Identity=32.3170731707317, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=401, Percent_Identity=38.1546134663342, Blast_Score=273, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6323470, Length=401, Percent_Identity=32.6683291770574, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=28.9808917197452, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=435, Percent_Identity=24.5977011494253, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357415, Length=377, Percent_Identity=34.7480106100796, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI28574759, Length=426, Percent_Identity=27.9342723004695, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161085790, Length=412, Percent_Identity=28.1553398058252, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=30.166270783848, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI281366494, Length=430, Percent_Identity=22.093023255814, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24667139, Length=430, Percent_Identity=22.093023255814, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24667143, Length=430, Percent_Identity=22.093023255814, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11; =2.6.1.17 [H]

Molecular weight: Translated: 43861; Mature: 43729

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCCCHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNELHAVK
HHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRIGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHCCCCHHHHHHH
YMHYGVTPDILTSAKALGGGFPVSAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
HHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHEEE
GAEEGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAVAKVIGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIEQTAITRATFDEVILPIYAPAEFIPVKGQGSRIWDQQGKEYVDFAGGIAVTALGHCH
CCCHHHHHHHHHHHHHEEEECCCEEEEECCCCCCCHHHCCCHHHHHCCCHHEEHHHCCC
PALVNALKTQGETLWHISNVFTNEPALRLGRKLIEATFAERVVFMNSGTEANETAFKLAR
HHHHHHHHHCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHH
HYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNELHAVK
HHHHHCCCCCCEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCEEECCHHHHHHHH
AVMDDHTCAVVVEPIQGEGGVTAATPEFLQGLRELCDQHQALLVFDEVQCGMGRIGDLFA
HHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHCCCCHHHHHHH
YMHYGVTPDILTSAKALGGGFPVSAMLTTAEIASAFHPGSHGSTYGGNPLACAVAGAAFD
HHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHC
IINTPEVLEGIQAKRQRFVDHLQKIDQQYDVFSDIRGMGLLIGAELKPQYKGRARDFLYA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHEEE
GAEEGVMVLNAGPDVMRFAPSLVVEDADIDEGMHRFAHAVAKVIGA
CCCCCEEEEECCCHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]