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The map label for this gene is uraA [H]

Identifier: 218690612

GI number: 218690612

Start: 2869319

End: 2870608

Strand: Reverse

Name: uraA [H]

Synonym: ECED1_2920

Alternate gene names: 218690612

Gene position: 2870608-2869319 (Counterclockwise)

Preceding gene: 218690613

Following gene: 218690611

Centisome position: 55.1

GC content: 51.94

Gene sequence:

>1290_bases
ATGACGCGCCGTGCTATCGGGGTGAGTGAAAGACCGCCACTTTTACAGACAATCCCGCTTAGTTTGCAACATTTGTTCGC
CATGTTTGGTGCAACCGTCCTGGTGCCCGTCTTATTTCATATTAACCCGGCGACTGTACTGTTATTTAACGGTATAGGAA
CACTGCTGTATCTCTTCATCTGTAAAGGGAAAATTCCGGCTTATCTTGGTTCCAGCTTTGCCTTTATTTCACCGGTATTG
TTACTGTTGCCGTTGGGGTATGAAGTCGCGCTGGGCGGCTTTATTATGTGCGGCGTGCTGTTCTGCCTGGTTTCTTTTAT
CGTGAAGAAAGCGGGGACCGGCTGGCTGGACGTGCTGTTTCCACCTGCGGCAATGGGCGCAATCGTTGCCGTCATCGGTC
TGGAGCTGGCGGGCGTAGCTGCCGGTATGGCGGGTTTACTCCCGGCTGAAGGGCAAACGCCAGACTCCAAAACCATCATC
ATCTCTATTACCACCCTGGCGGTCACGGTTTTAGGTTCCGTGCTGTTTCGTGGTTTCCTAGCAATTATCCCGATTTTAAT
TGGCGTGCTGGTGGGGTACGCGCTCTCTTTCGCAATGGGAATTGTCGATACCACGCCGATTATTAATGCTCACTGGTTTG
CGCTGCCGACCCTCTATACGCCGCGCTTCGAGTGGTTTGCCATTCTGACTATTCTGCCAGCGGCGTTAGTGGTTATTGCC
GAACACGTAGGGCACCTGGTCGTAACGGCTAATATCGTCAAAAAAGATCTGCTGCGCGATCCAGGTCTGCACCGTTCGAT
GTTTGCTAACGGCTTGTCGACCGTGATCTCCGGTTTCTTTGGTTCCACACCAAACACCACCTATGGGGAAAACATCGGTG
TGATGGCGATCACCCGTGTTTACAGTACCTGGGTTATCGGCGGTGCGGCGATTTTCGCTATCCTGCTTTCCTGCGTCGGT
AAACTGGCTGCTGCTATCCAGATGATTCCATTGCCGGTGATGGGCGGCGTTTCGCTGCTGCTTTACGGGGTCATCGGTGC
TTCCGGTATTCGTGTGTTGATCGAATCGAAAGTGGATTACAACAAAGCACAGAACCTGATCCTGACTTCCGTTATTTTGA
TCATCGGCGTCAGTGGTGCGAAGGTAAACATTGGCGCGGCGGAGCTGAAAGGTATGGCGCTGGCGACCATCATCGGTATC
GGCTTAAGTTTGATCTTCAAACTGATTAGTATGCTGCGCCCTGAAGAAGTGGTGCTGGACGCAGAAGACGCGGATATAAC
AGACAAATAA

Upstream 100 bases:

>100_bases
TTTGGTACGAAATAAAGAATAAAAATAATTAAAGCCGACTTTAAGAGTCGGCTTTTTTTTGAGTAAAGCGCCTATAACAC
ATAATACAGAGGATAATACT

Downstream 100 bases:

>100_bases
TGTACCGACCGGGCAGTGTTGCTGCCCGGTTCAAACATCATGGGATTCTGTGGTAAACTTCTCGCGATTTTGTGAAATCC
TGGTTGAGGTATCTCTGAAC

Product: uracil transporter

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVLFPPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTII
ISITTLAVTVLGSVLFRGFLAIIPILIGVLVGYALSFAMGIVDTTPIINAHWFALPTLYTPRFEWFAILTILPAALVVIA
EHVGHLVVTANIVKKDLLRDPGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIFAILLSCVG
KLAAAIQMIPLPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVNIGAAELKGMALATIIGI
GLSLIFKLISMLRPEEVVLDAEDADITDK

Sequences:

>Translated_429_residues
MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVLFPPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTII
ISITTLAVTVLGSVLFRGFLAIIPILIGVLVGYALSFAMGIVDTTPIINAHWFALPTLYTPRFEWFAILTILPAALVVIA
EHVGHLVVTANIVKKDLLRDPGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIFAILLSCVG
KLAAAIQMIPLPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVNIGAAELKGMALATIIGI
GLSLIFKLISMLRPEEVVLDAEDADITDK
>Mature_428_residues
TRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVLL
LLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVLFPPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTIII
SITTLAVTVLGSVLFRGFLAIIPILIGVLVGYALSFAMGIVDTTPIINAHWFALPTLYTPRFEWFAILTILPAALVVIAE
HVGHLVVTANIVKKDLLRDPGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIFAILLSCVGK
LAAAIQMIPLPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVNIGAAELKGMALATIIGIG
LSLIFKLISMLRPEEVVLDAEDADITDK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=220, Percent_Identity=26.8181818181818, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI40316845, Length=220, Percent_Identity=26.8181818181818, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1788843, Length=429, Percent_Identity=99.5337995337995, Blast_Score=836, Evalue=0.0,
Organism=Escherichia coli, GI87081818, Length=425, Percent_Identity=36.7058823529412, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082181, Length=391, Percent_Identity=27.6214833759591, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790087, Length=409, Percent_Identity=25.4278728606357, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17541904, Length=223, Percent_Identity=25.5605381165919, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=216, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=173, Percent_Identity=29.4797687861272, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356175, Length=432, Percent_Identity=23.8425925925926, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45107; Mature: 44976

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVLF
HCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
PPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTIIISITTLAVTVLGSVLFRGFL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
AIIPILIGVLVGYALSFAMGIVDTTPIINAHWFALPTLYTPRFEWFAILTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLLRDPGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRV
HHHCHHEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
YSTWVIGGAAIFAILLSCVGKLAAAIQMIPLPVMGGVSLLLYGVIGASGIRVLIESKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVNIGAAELKGMALATIIGIGLSLIFKLISMLRPEEVVLD
HHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AEDADITDK
CCCCCCCCC
>Mature Secondary Structure 
TRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEHHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVLF
HCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
PPAAMGAIVAVIGLELAGVAAGMAGLLPAEGQTPDSKTIIISITTLAVTVLGSVLFRGFL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
AIIPILIGVLVGYALSFAMGIVDTTPIINAHWFALPTLYTPRFEWFAILTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLLRDPGLHRSMFANGLSTVISGFFGSTPNTTYGENIGVMAITRV
HHHCHHEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
YSTWVIGGAAIFAILLSCVGKLAAAIQMIPLPVMGGVSLLLYGVIGASGIRVLIESKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVNIGAAELKGMALATIIGIGLSLIFKLISMLRPEEVVLD
HHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
AEDADITDK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]