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The map label for this gene is mdtA [H]

Identifier: 218690132

GI number: 218690132

Start: 2363041

End: 2364288

Strand: Direct

Name: mdtA [H]

Synonym: ECED1_2420

Alternate gene names: 218690132

Gene position: 2363041-2364288 (Clockwise)

Preceding gene: 218690129

Following gene: 218690133

Centisome position: 45.36

GC content: 54.73

Gene sequence:

>1248_bases
ATGAAAGGCAGTTATAAATCCCGTTGGGTAATCGTAATCGTGGTGGTTATCGCCGCCATCGCCGCATTCTGGTTCTGGCA
AGGCCGCAATGACTCCCGGAGTGCAGCCCCAGGGGCGACGAAACAAGCGCAGCAATCGCCAGCGAGTGGTCGCCGTGGTA
TGCGTTCCGGCCCATTAGCCCCGGTTCAGGCGGCGACCGCAGTAGAACAGGCTGTTCCGCGTTACCTCACCGGGCTTGGC
ACCATTACCGCCGCTAATACTGTTACGGTGCGCAGCCGCGTGGACGGTCAACTGATGGCGTTACATTTCCAGGAAGGCCA
GCAGGTCAAAGCAGGCGATTTACTGGCAGAAATTGACCCAAGCCAGTTCAAAGTTGCATTAGCACAAGCCCAGGGCCAAC
TGGCAAAAGATAAAGCCACGCTCGCCAACGCCCGCCGTGACCTGGCGCGTTATCAACAACTGGCAAAAACCAATCTCGTA
TCTCGTCAGGAACTGGATGCCCAACAAGCGCTGGTCAGTGAAACCGAAGGTACCATTAAGGCTGATGAAGCAAGCGTCGC
CAGCGCGCAATTGCAACTCGACTGGAGCCGTATCACCGCACCAGTTGATGGTCGCGTTGGTCTCAAGCAGGTTGATGTTG
GTAACCAAATCTCCAGTGGCGACACCACCGGGATTGTGGTGATCACCCAAACACATCCTATCGATCTGGTCTTTACTCTG
CCGGAAAGCGATATCGCCACCGTTGTACAGGCACAAAAAGCCGGAAAACCGCTGGTGGTAGAAGCCTGGGATCGCACCAA
CTCGAAGAAGTTAAGTGAAGGCACGCTGTTAAGCCTTGATAACCAAATCGATGCCACTACCGGTACGATTAAAGTGAAAG
CACGCTTTAATAATCAGGATGATGCGCTGTTTCCCAATCAGTTTGTTAACGCGCGCATGTTAGTCGACACCGAACAAAAC
GCCGTGGTGATCCCCACCGCCGCTCTGCAAATGGGCAACGAAGGCCATTTTGTCTGGGTACTGAATAGCGAAAACAAAGT
CAGCAAACATCTGGTGACACCGGGCATTCAGGACAGTCAGAAAGTGGTGATCCGCGCAGGTATTTCTGCGGGCGATCGCG
TGGTGACAGACGGCATTGATCGCCTGACCGAAGGGGCGAAAGTGGAAGTGGTGGAAGCCCAGAGCGCCACCACTCCAGAA
GAGAAAGCCACCAGCCGCGAATACGCGAAAAAAGGAGCACGCTCCTGA

Upstream 100 bases:

>100_bases
ATTCCAGACAGTGTTTCATAATTCCTCCATTTTTCTCCCTTATTGGCTGGCTACACTAGTATCATTCCGCGAAACGTTTC
AGGAAGAGAAACTCTTAACG

Downstream 100 bases:

>100_bases
TGCAGGTGTTACCCCCGAGCAGCACAGGCGGCCCGTCTCGCCTGTTTATTATGCGTCCTGTCGCCACCACGCTGCTGATG
GTGGCGATCTTACTCGCCGG

Product: multidrug efflux system subunit MdtA

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSRSAAPGATKQAQQSPASGRRGMRSGPLAPVQAATAVEQAVPRYLTGLG
TITAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLV
SRQELDAQQALVSETEGTIKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTL
PESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQN
AVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPE
EKATSREYAKKGARS

Sequences:

>Translated_415_residues
MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSRSAAPGATKQAQQSPASGRRGMRSGPLAPVQAATAVEQAVPRYLTGLG
TITAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLV
SRQELDAQQALVSETEGTIKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTL
PESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQN
AVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPE
EKATSREYAKKGARS
>Mature_415_residues
MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSRSAAPGATKQAQQSPASGRRGMRSGPLAPVQAATAVEQAVPRYLTGLG
TITAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDPSQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLV
SRQELDAQQALVSETEGTIKADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTL
PESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQDDALFPNQFVNARMLVDTEQN
AVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQKVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPE
EKATSREYAKKGARS

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=415, Percent_Identity=99.5180722891566, Blast_Score=830, Evalue=0.0,
Organism=Escherichia coli, GI1789929, Length=311, Percent_Identity=28.2958199356913, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1786668, Length=362, Percent_Identity=29.2817679558011, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789665, Length=320, Percent_Identity=29.0625, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87081796, Length=394, Percent_Identity=26.3959390862944, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87081951, Length=161, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44513; Mature: 44513

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSRSAAPGATKQAQQSPASGRRGMRSGPLA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCHHCCCCCCCCCC
PVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDP
CHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCEEEEEEECCCCEECCCCEEEECCH
SQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEE
ADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTL
ECCCHHEEEEEEEEHHHCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCEEEEEEC
PESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQD
CCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCC
DALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQ
CCCCCHHHCCEEEEEECCCCEEEEEHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCCCCC
KVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPEEKATSREYAKKGARS
EEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKGSYKSRWVIVIVVVIAAIAAFWFWQGRNDSRSAAPGATKQAQQSPASGRRGMRSGPLA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCCCHHCCCCCCCCCC
PVQAATAVEQAVPRYLTGLGTITAANTVTVRSRVDGQLMALHFQEGQQVKAGDLLAEIDP
CHHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCEEEEEEECCCCEECCCCEEEECCH
SQFKVALAQAQGQLAKDKATLANARRDLARYQQLAKTNLVSRQELDAQQALVSETEGTIK
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEE
ADEASVASAQLQLDWSRITAPVDGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTL
ECCCHHEEEEEEEEHHHCCCCCCCCCCCEEECCCCCCCCCCCCEEEEEEECCCEEEEEEC
PESDIATVVQAQKAGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKVKARFNNQD
CCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEECCCC
DALFPNQFVNARMLVDTEQNAVVIPTAALQMGNEGHFVWVLNSENKVSKHLVTPGIQDSQ
CCCCCHHHCCEEEEEECCCCEEEEEHHHHHCCCCCCEEEEECCCCCHHHHHCCCCCCCCC
KVVIRAGISAGDRVVTDGIDRLTEGAKVEVVEAQSATTPEEKATSREYAKKGARS
EEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA