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The map label for this gene is ydhC [H]

Identifier: 218689605

GI number: 218689605

Start: 1817403

End: 1818614

Strand: Direct

Name: ydhC [H]

Synonym: ECED1_1859

Alternate gene names: 218689605

Gene position: 1817403-1818614 (Clockwise)

Preceding gene: 218689603

Following gene: 218689606

Centisome position: 34.89

GC content: 52.89

Gene sequence:

>1212_bases
ATGCAACCTGGGAAAAGATTTTTAGTCTGGCTGGCAGGTTTGAGCGTACTCGGTTTTCTGGCAACCGATATGTATCTGCC
TGCTTTCGCCGCCATACAGGCCGACCTGCAAACGCCTGCGTCTGCTGTCAGTGCCAGCCTTAGTCTGTTCCTTGCCGGTT
TTGCCGCAGCCCAGCTTCTGTGGGGGCCACTCTCCGACCGTTATGGTCGTAAACCGGTGTTATTCATCGGCCTGACAATT
TTTGCGTTAGGTAGTCTGGGGATGCTGTGGGTAGAAAACGCCGCCACGCTGCTGATATTGCGTTTTGTACAGGCTGTGGG
TGTCTGCGCCGCGGCGGTTATCTGGCAAGCATTAGTGACAGATTATTATCCTTCACAGAAAGTTAACCGTATTTTTGCGA
CCATCATGCCGCTGGTGGGTCTGTCTCCGGCACTGGCTCCTCTGTTAGGAAGCTGGCTGCTGGTCCATTTTTCCTGGCAG
GCGATTTTCGCCACCCTGTTTGCCATTACCGTGGTGCTGATTCTGCCTATTTTCTGGCTCAAACCTACGACGAAGGCCCG
TAACAATAGTCAGGATGGTCTGACCTTTACCGACCTGCTACATTCTAAAACCTATCGCGGCAACGTGCTGATATACGCGG
CCTGTTCAGCCAGTTTTTTTGCATGGCTGACCGGTTCACCGTTCATCCTTAGTGAAATGGGTTACAGCCCGGCAGTTATT
GGTTTAAGTTATGTCCCGCAAACTATCGCGTTTCTGATTGGTGGTTATGGCTGTCGCGCCGCGCTGCAGAAATGGCAAGG
CAAGCAGTTATTACCGTGGTTGCTGGTACTGTTTGCTGTCAGCGTCATTGCGACCTGGGCTGCGGGCTTCATTAGCCATG
TATCGTTGGTCGAAATCCTGATCCCATTCTGTGTGATGGCGATTGCCAACGGCGCGATCTACCCGATTGTTGTTGCCCAG
GCGCTGCGTCCCTTCCCACATGCAACCGGTCGCGCCGCAGCGTTGCAGAACACTCTGCAACTGGGTCTGTGCTTCCTCGC
AAGTCTGGTAGTTTCCTGGCTTATCAGTATCAGTACGCCATTGCTCACCACCACCAGCGTGATGTTATCAACAGTAGTGC
TGGTCGCTCTGGGTTACATGATGCAACGTTGTGAAGAAGTTGGCTGCCAGAATCATGGCAATGCCGAAGTCGCTCATAGC
GAATCACACTGA

Upstream 100 bases:

>100_bases
AAATTTTTGAAACCAATCATCAAATATTACCGTTTCACAACACTAATTTCACTCCCTACACTTTGCGGCGGTGTTTAATT
GAGAGATTTAGAGAATATAC

Downstream 100 bases:

>100_bases
TCTATATCTATATACTTATACTTAGGCTGCTAACAAAATTTTGTTGTATGATTGAAATTAGCGGCCTATACTAATTTCGA
GTTGTTAAAACTACGATAAA

Product: inner membrane transport protein YdhC

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLFIGLTI
FALGSLGMLWVENAATLLILRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLLGSWLLVHFSWQ
AIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLHSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI
GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQ
ALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHS
ESH

Sequences:

>Translated_403_residues
MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLFIGLTI
FALGSLGMLWVENAATLLILRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLLGSWLLVHFSWQ
AIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLHSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI
GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQ
ALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHS
ESH
>Mature_403_residues
MQPGKRFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAAAQLLWGPLSDRYGRKPVLFIGLTI
FALGSLGMLWVENAATLLILRFVQAVGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLLGSWLLVHFSWQ
AIFATLFAITVVLILPIFWLKPTTKARNNSQDGLTFTDLLHSKTYRGNVLIYAACSASFFAWLTGSPFILSEMGYSPAVI
GLSYVPQTIAFLIGGYGCRAALQKWQGKQLLPWLLVLFAVSVIATWAAGFISHVSLVEILIPFCVMAIANGAIYPIVVAQ
ALRPFPHATGRAAALQNTLQLGLCFLASLVVSWLISISTPLLTTTSVMLSTVVLVALGYMMQRCEEVGCQNHGNAEVAHS
ESH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=403, Percent_Identity=99.0074441687345, Blast_Score=795, Evalue=0.0,
Organism=Escherichia coli, GI1788509, Length=344, Percent_Identity=28.7790697674419, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790146, Length=242, Percent_Identity=29.3388429752066, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082312, Length=340, Percent_Identity=25, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790794, Length=221, Percent_Identity=27.1493212669683, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1787065, Length=217, Percent_Identity=25.3456221198157, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319657, Length=167, Percent_Identity=25.748502994012, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43427; Mature: 43427

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]