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The map label for this gene is rnb [H]

Identifier: 218689279

GI number: 218689279

Start: 1467299

End: 1469230

Strand: Reverse

Name: rnb [H]

Synonym: ECED1_1497

Alternate gene names: 218689279

Gene position: 1469230-1467299 (Counterclockwise)

Preceding gene: 218689280

Following gene: 218689278

Centisome position: 28.2

GC content: 53.11

Gene sequence:

>1932_bases
ATGTTTCAGGACAACCCGCTGCTAGCGCAGCTTAAACAGCAACTGCATTCCCAGACGCCACGCGCTGAAGGGGTGGTAAA
AGCCACAGAAAAAGGCTTTGGCTTCCTGGAAGTCGACGCGCAAAAAAGTTATTTCATTCCGCCGCCGCAGATGAAAAAAG
TCATGCATGGCGACCGAATTATCGCGGTGATCCACAGTGAAAAAGAACGTGAATCCGCAGAGCCAGAAGAACTGGTTGAA
CCGTTCCTGACTCGTTTCGTGGGTAAAGTTCAGGGCAAAAATGACCGTCTGGCCATCGTTCCTGATCATCCACTCTTAAA
CGCCATTCCTTGCCGCGCAGCCCGTGGCCTGAACCACGAGTTTAAAGAAGGCGACTGGGCGGTTGCCGAAATGCGCCGTC
ATCCGCTGAAAGGCGATCGTTCTTTCTATGCTGAACTGACACAATACATCACTTTTGGTGACGATCACTTTGTACCGTGG
TGGGTTACCCTTGCGCGTCATAATCTGGAAAAAGAAGCACCAGACGGCGTCGCTACCGAAATGCTCGATGAAGGTCTGGT
TCGTGAAGATCTGACTGCGCTGGATTTTGTCACCATCGACAGTGCCAGCACAGAAGATATGGATGACGCCCTTTTCGCCA
AGGCGTTACCGGATGGCAAACTTCAGCTGATTGTGGCGATTGCCGATCCAACCGCGTGGATTGCTGAAGGCAGCAAGCTG
GACAAAGCCGCGAAAATTCGCGCATTCACCAACTATCTGCCTGGCTTCAACATCCCTATGCTGCCTCGCGAGCTTTCTGA
CGATCTCTGCTCACTGCGCGCCAATGAAGTCCGCCCGGTACTGGCATGCCGCATGACGCTCTCCACTGATGGCACCATTG
AAGATAATATCGAATTCTTTGCCGCCACCATCGAATCCAAAGCGAAGCTGGTGTATGACCAGGTTTCTGACTGGCTGGAA
AATACCGGTGACTGGCAGCCTGAAAGCGAAGCAATTGCCGAACAAGTCCGTTTGCTAGCACAAATTTGCCAACGCCGCGG
CGAGTGGCGTCATAACCACGCACTGGTGTTTAAAGATCGCCCGGATTACCGCTTTATTCTCGGTGAAAAAGGTGAAGTGC
TGGATATCGTTGCCGAGCCTCGTCGCATTGCCAACCGTATCGTCGAAGAAGCGATGATTGCCGCTAACATTTGTGCGGCC
CGCGTACTGCGCGATAAGCTCGGTTTTGGCATCTATAACGTGCATATGGGCTTTGATCCGGCGAATGCCGACGCGCTGGC
AGCGTTGCTGAAAACGCACGGTCTGCATGTCGATGCTGAAGAAGTGCTCACGCTGGACGGTTTCTGCAAACTGCGTCGTG
AACTGGATGCGCAACCAACTGGTTTCCTCGACAGCCGCATTCGTCGCTTCCAGTCATTTGCTGAAATTAGCACTGAACCC
GGTCCTCACTTTGGCCTCGGTCTGGAAGCATACGCCACCTGGACTTCGCCGATCCGTAAATATGGCGACATGATCAACCA
CCGTCTGCTGAAAGCGGTTATCAAAGGCGAAACTGCGACGCGTCCACAGGATGAAATCACTGTCCAAATGGCCGAGCGTC
GCCGTCTCAACCGGATGGCAGAACGTGATGTTGGCGACTGGTTATACGCACGCTTCCTGAAAGACAAAGCCGGGACCGAC
ACCCGTTTCGCGGCGGAAATTGTCGATATCAGCCGTGGCGGCATGCGTGTTCGTTTGGTTGATAACGGCGCTATCGCCTT
TATTCCAGCACCTTTCTTACACGCTGTGCGCGATGAACTGGTTTGCAGCCAGGAAAACGGCACTGTACAAATTAAAGGTG
AAACGGCTTACAAAGTGACTGACGTTATTGACGTCACCATTGCCGAAGTCCGCATGGAAACCCGCAGCATTATTGCGCGC
CCAGTCGCGTAA

Upstream 100 bases:

>100_bases
CGCTTAAAAATCGCGTTGGGTGAGACATATTAACCTTGCCGCGTCAGACAGATTCGCGTAAAACTGTCAGCCGCTCTAAT
GGCCACCAAAATAGACAATT

Downstream 100 bases:

>100_bases
TCTCCTTTCACGGCCCATTCCTCATGGATGGGCCGTTTATTTCCCCGCTCAACCTTCCTCATATCCCGGCAGATTTTTAA
CTGACTTTCGTTTGAAAACT

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVE
PFLTRFVGKVQGKNDRLAIVPDHPLLNAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPW
WVTLARHNLEKEAPDGVATEMLDEGLVREDLTALDFVTIDSASTEDMDDALFAKALPDGKLQLIVAIADPTAWIAEGSKL
DKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSTDGTIEDNIEFFAATIESKAKLVYDQVSDWLE
NTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAA
RVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTEP
GPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGTD
TRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETAYKVTDVIDVTIAEVRMETRSIIAR
PVA

Sequences:

>Translated_643_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVE
PFLTRFVGKVQGKNDRLAIVPDHPLLNAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPW
WVTLARHNLEKEAPDGVATEMLDEGLVREDLTALDFVTIDSASTEDMDDALFAKALPDGKLQLIVAIADPTAWIAEGSKL
DKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSTDGTIEDNIEFFAATIESKAKLVYDQVSDWLE
NTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAA
RVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTEP
GPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGTD
TRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETAYKVTDVIDVTIAEVRMETRSIIAR
PVA
>Mature_643_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKERESAEPEELVE
PFLTRFVGKVQGKNDRLAIVPDHPLLNAIPCRAARGLNHEFKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPW
WVTLARHNLEKEAPDGVATEMLDEGLVREDLTALDFVTIDSASTEDMDDALFAKALPDGKLQLIVAIADPTAWIAEGSKL
DKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSTDGTIEDNIEFFAATIESKAKLVYDQVSDWLE
NTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAA
RVLRDKLGFGIYNVHMGFDPANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTEP
GPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMAERDVGDWLYARFLKDKAGTD
TRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDELVCSQENGTVQIKGETAYKVTDVIDVTIAEVRMETRSIIAR
PVA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=387, Percent_Identity=26.0981912144703, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI190014625, Length=387, Percent_Identity=26.0981912144703, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI134288890, Length=365, Percent_Identity=29.3150684931507, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI219521928, Length=456, Percent_Identity=25, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI19115966, Length=456, Percent_Identity=25, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1787542, Length=644, Percent_Identity=99.2236024844721, Blast_Score=1288, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=651, Percent_Identity=26.2672811059908, Blast_Score=179, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17553506, Length=409, Percent_Identity=27.6283618581907, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI212645896, Length=462, Percent_Identity=27.0562770562771, Blast_Score=115, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6324552, Length=420, Percent_Identity=24.047619047619, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24649634, Length=370, Percent_Identity=28.3783783783784, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24654592, Length=451, Percent_Identity=26.6075388026608, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI19922976, Length=451, Percent_Identity=26.6075388026608, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24654597, Length=451, Percent_Identity=26.6075388026608, Blast_Score=115, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 72306; Mature: 72306

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IAVIHSEKERESAEPEELVEPFLTRFVGKVQGKNDRLAIVPDHPLLNAIPCRAARGLNHE
EEEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHCCCCCC
FKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPWWVTLARHNLEKEAPDGVATE
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
MLDEGLVREDLTALDFVTIDSASTEDMDDALFAKALPDGKLQLIVAIADPTAWIAEGSKL
HHHCCHHHHCCCHHEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCHHHHCCCCH
DKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSTDGTIEDNIEFF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEHEEEEEECCCCCCCCCHHHH
AATIESKAKLVYDQVSDWLENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKLGFGIYNVHMGFDP
CCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
ANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTEP
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
GPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ERDVGDWLYARFLKDKAGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDEL
HHCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHHH
VCSQENGTVQIKGETAYKVTDVIDVTIAEVRMETRSIIARPVA
HEECCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IAVIHSEKERESAEPEELVEPFLTRFVGKVQGKNDRLAIVPDHPLLNAIPCRAARGLNHE
EEEEECCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHCCCCCC
FKEGDWAVAEMRRHPLKGDRSFYAELTQYITFGDDHFVPWWVTLARHNLEKEAPDGVATE
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHH
MLDEGLVREDLTALDFVTIDSASTEDMDDALFAKALPDGKLQLIVAIADPTAWIAEGSKL
HHHCCHHHHCCCHHEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCHHHHCCCCH
DKAAKIRAFTNYLPGFNIPMLPRELSDDLCSLRANEVRPVLACRMTLSTDGTIEDNIEFF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEHEEEEEECCCCCCCCCHHHH
AATIESKAKLVYDQVSDWLENTGDWQPESEAIAEQVRLLAQICQRRGEWRHNHALVFKDR
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECC
PDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKLGFGIYNVHMGFDP
CCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
ANADALAALLKTHGLHVDAEEVLTLDGFCKLRRELDAQPTGFLDSRIRRFQSFAEISTEP
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCC
GPHFGLGLEAYATWTSPIRKYGDMINHRLLKAVIKGETATRPQDEITVQMAERRRLNRMA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
ERDVGDWLYARFLKDKAGTDTRFAAEIVDISRGGMRVRLVDNGAIAFIPAPFLHAVRDEL
HHCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHHH
VCSQENGTVQIKGETAYKVTDVIDVTIAEVRMETRSIIARPVA
HEECCCCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA