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The map label for this gene is gmr [H]

Identifier: 218689278

GI number: 218689278

Start: 1465080

End: 1467065

Strand: Reverse

Name: gmr [H]

Synonym: ECED1_1496

Alternate gene names: 218689278

Gene position: 1467065-1465080 (Counterclockwise)

Preceding gene: 218689279

Following gene: 218689277

Centisome position: 28.16

GC content: 48.39

Gene sequence:

>1986_bases
ATGAAAACCGTTAGGGAGTCCGCAACGTTGTACAACTTTCTCGGATCGCACAATCCATACTGGCGGTTGACGGAAAGCAG
CGATGTTTTGCGCTTTTCTACCACCGAAATCACAGAACCCGATCGTATTTTGCAACTATCTGCCGAACAGGCTGCTCGCA
TCAGGGAAATGACGGTCATCACCTCCAGCCTGATGATGAGTCTGACCGTCGATGAAAGCGATCTTTCTGTGCATCTGGTA
GGACGAAAAATCAATAAACGAGAATGGGGAGGCAACGCGTCTGCATGGCATGACACATCGGCGGTTGCTCGTGATTTATC
ACATGGGCTTTCCTTTGCTGAGCAGGTAGTTTCTGAAGCACATTCCGCAATAGTGATTCTCGACAGCCGGGGGAATATCC
AGCGCTTCAATCGGTTATGTGAAGATTACACAGGGTTGAAAGAACACGACGTCATTGGGCAAAGCGTGTTTAAACTGTTT
ATGAGTCGTCGTGAAGCTGCGGCATCCAGGCGCAATAACCGTGTATTTTTTCGAAGCGGCAATGCATATGAAGTCGAACT
ATGGATACCAACACGTAAAGGCCAGCGGCTGTTTCTGTTTCGCAATAAATTTGTCCACAGCGGCAGTGGCAAAAACGAGA
TTTTTTTAATCTGTTCCGGCACCGACATTACCGAAGAGCGCCGCGCTCAGGAGCGACTGCGTATTCTGGCAAATACCGAC
AGTATCACCGGACTGCCGAATCGTAACGCGATGCAGGAGTTAATCGATCACGCTATTAATCAGGCAGATAACAATAAAGT
TGGGGTTGTGTATCTTGATTTGGATAATTTTAAAAAGGTCAACGACGCCTATGGGCATTTGTTTGGTGACCAGTTATTAC
GCGACGTGTCATTGGCTATTTTAAGCTGTCTCGAACATGACCAGGTGTTGGCGCGTCCAGGTGGCGATGAGTTTCTGGTA
CTGGCATCCAATACCTCACAAAGCGCGCTGGAAGCATTGGCATCACGAATTTTGACCCGCTTACGACTCCCCTTTCGCAT
TGGTTTAATTGAAGTTTATACCAGCTGTTCAGTAGGTATTTCACTCTCTCCCGAACATGGTTCGGACAGCGCGGCTATTA
TTCGTCACGCCGACACAGCAATGTACACAGCGAAGGAAGGCGGACGAGGACAATTTTGCGTTTTTACCCCAGAAATGAAT
CAGCGGGTATTTGAATATCTCTGGCTGGATACCAACTTGCGTAAAGCACTGGAAAACGATCAGTTGGTTATTCACTATCA
ACCGAAAATCACCTGGCGTGGCGAAGTGCGCAGTCTGGAAGCACTAGTACGTTGGCAGTCACCTGAACGTGGGTTGATTC
CACCGTTGGACTTCATTTCCTACGCCGAAGAATCAGGGCTAATTGTGCCTTTAGGCCGTTGGGTGATTCTCGATGTCGTA
CGCCAGGTAGCGAAGTGGCGGGATAAAGGCATTAACCTGCGAGTGGCGGTAAATATTTCTGCACGTCAGCTCGCCGATCA
AACCATTTTCACCGCCCTGAAACAGGTTCTCCAGGAACTCAATTTTGAATACTGCCCTATAGATGTTGAACTGACGGAGA
GCTGCCTGATTGAGAATGATGAACTGGCACTGTCTGTTATTCAACAATTTAGCCGATTAGGTGCGCAAGTTCATCTGGAC
GATTTTGGTACCGGCTACTCTTCACTTTCGCAACTGGCGCGCTTTCCGATCGATGCCATCAAACTTGACCAGGTTTTTGT
TCGGGATATTCACAAACAGCCTGTCTCGCAATCACTGGTCCGGGCGATCGTCGCTGTGGCCCAGGCATTGAATCTTCAGG
TGATCGCCGAAGGTGTAGAAAGTGCAAAGGAAGATGCTTTTTTAACCAAGAACGGGATCAATGAGCGACAAGGATTTTTG
TTTGCCAAACCGATGCCCGCCGTTGCCTTCGAACGCTGGTATAAACGCTATCTGAAGCGCACATAA

Upstream 100 bases:

>100_bases
TATAAAAAAACAATGTGTTTAGCCGCCGTTAATTTCATGTAAGTCATGTTGTTCCTTTTATTTAACTGCGGACTCCGCTG
TTAACCGGAGGATATGCATC

Downstream 100 bases:

>100_bases
GTAGATGAATATATATACTTAGCGCTATATTCCGTCATTATATATCGTATTCCCGGATGATAATTAGCCGTTGCTGTTAA
ACACTTCTCTTTTAGCGGCA

Product: RNase II stability modulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 661; Mature: 661

Protein sequence:

>661_residues
MKTVRESATLYNFLGSHNPYWRLTESSDVLRFSTTEITEPDRILQLSAEQAARIREMTVITSSLMMSLTVDESDLSVHLV
GRKINKREWGGNASAWHDTSAVARDLSHGLSFAEQVVSEAHSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLF
MSRREAAASRRNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLV
LASNTSQSALEALASRILTRLRLPFRIGLIEVYTSCSVGISLSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMN
QRVFEYLWLDTNLRKALENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQFSRLGAQVHLD
DFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFL
FAKPMPAVAFERWYKRYLKRT

Sequences:

>Translated_661_residues
MKTVRESATLYNFLGSHNPYWRLTESSDVLRFSTTEITEPDRILQLSAEQAARIREMTVITSSLMMSLTVDESDLSVHLV
GRKINKREWGGNASAWHDTSAVARDLSHGLSFAEQVVSEAHSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLF
MSRREAAASRRNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLV
LASNTSQSALEALASRILTRLRLPFRIGLIEVYTSCSVGISLSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMN
QRVFEYLWLDTNLRKALENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQFSRLGAQVHLD
DFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFL
FAKPMPAVAFERWYKRYLKRT
>Mature_661_residues
MKTVRESATLYNFLGSHNPYWRLTESSDVLRFSTTEITEPDRILQLSAEQAARIREMTVITSSLMMSLTVDESDLSVHLV
GRKINKREWGGNASAWHDTSAVARDLSHGLSFAEQVVSEAHSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLF
MSRREAAASRRNNRVFFRSGNAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
SITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAILSCLEHDQVLARPGGDEFLV
LASNTSQSALEALASRILTRLRLPFRIGLIEVYTSCSVGISLSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMN
QRVFEYLWLDTNLRKALENDQLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIENDELALSVIQQFSRLGAQVHLD
DFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLVRAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFL
FAKPMPAVAFERWYKRYLKRT

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=660, Percent_Identity=98.1818181818182, Blast_Score=1337, Evalue=0.0,
Organism=Escherichia coli, GI87081921, Length=439, Percent_Identity=33.9407744874715, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI226510982, Length=427, Percent_Identity=31.8501170960187, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1788502, Length=246, Percent_Identity=30.4878048780488, Blast_Score=140, Evalue=4e-34,
Organism=Escherichia coli, GI1790496, Length=249, Percent_Identity=32.1285140562249, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081743, Length=247, Percent_Identity=30.3643724696356, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI87081845, Length=238, Percent_Identity=34.8739495798319, Blast_Score=133, Evalue=4e-32,
Organism=Escherichia coli, GI1787055, Length=294, Percent_Identity=30.2721088435374, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788849, Length=439, Percent_Identity=26.879271070615, Blast_Score=120, Evalue=4e-28,
Organism=Escherichia coli, GI1786507, Length=256, Percent_Identity=29.6875, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI87081980, Length=259, Percent_Identity=30.8880308880309, Blast_Score=119, Evalue=9e-28,
Organism=Escherichia coli, GI1788381, Length=550, Percent_Identity=23.8181818181818, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082096, Length=427, Percent_Identity=25.5269320843091, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI87081977, Length=177, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1787816, Length=171, Percent_Identity=32.7485380116959, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1787262, Length=162, Percent_Identity=34.5679012345679, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87081881, Length=201, Percent_Identity=29.3532338308458, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1786584, Length=178, Percent_Identity=29.7752808988764, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788956, Length=152, Percent_Identity=34.8684210526316, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI145693134, Length=157, Percent_Identity=31.8471337579618, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082007, Length=169, Percent_Identity=34.9112426035503, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1787410, Length=129, Percent_Identity=37.2093023255814, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1789650, Length=437, Percent_Identity=21.5102974828375, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 74720; Mature: 74720

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50112 PAS ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVRESATLYNFLGSHNPYWRLTESSDVLRFSTTEITEPDRILQLSAEQAARIREMTVI
CCCHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCHHHEEECHHHHHHHHHHHHH
TSSLMMSLTVDESDLSVHLVGRKINKREWGGNASAWHDTSAVARDLSHGLSFAEQVVSEA
HHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
CCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
CEEEEEEEEECCCCCEEEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHEEECCC
SITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LSCLEHDQVLARPGGDEFLVLASNTSQSALEALASRILTRLRLPFRIGLIEVYTSCSVGI
HHHHCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCE
SLSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
EECCCCCCCCEEEEEECCHHEEEECCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHCCCC
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
CEEEEECCCEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECHHHHHHHHH
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHCCCC
ELALSVIQQFSRLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHCC
T
C
>Mature Secondary Structure
MKTVRESATLYNFLGSHNPYWRLTESSDVLRFSTTEITEPDRILQLSAEQAARIREMTVI
CCCHHHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCCCHHHEEECHHHHHHHHHHHHH
TSSLMMSLTVDESDLSVHLVGRKINKREWGGNASAWHDTSAVARDLSHGLSFAEQVVSEA
HHHHHEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
HSAIVILDSRGNIQRFNRLCEDYTGLKEHDVIGQSVFKLFMSRREAAASRRNNRVFFRSG
CCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NAYEVELWIPTRKGQRLFLFRNKFVHSGSGKNEIFLICSGTDITEERRAQERLRILANTD
CEEEEEEEEECCCCCEEEEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHEEECCC
SITGLPNRNAMQELIDHAINQADNNKVGVVYLDLDNFKKVNDAYGHLFGDQLLRDVSLAI
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LSCLEHDQVLARPGGDEFLVLASNTSQSALEALASRILTRLRLPFRIGLIEVYTSCSVGI
HHHHCCCCEEECCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCE
SLSPEHGSDSAAIIRHADTAMYTAKEGGRGQFCVFTPEMNQRVFEYLWLDTNLRKALEND
EECCCCCCCCEEEEEECCHHEEEECCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHCCCC
QLVIHYQPKITWRGEVRSLEALVRWQSPERGLIPPLDFISYAEESGLIVPLGRWVILDVV
CEEEEECCCEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECHHHHHHHHH
RQVAKWRDKGINLRVAVNISARQLADQTIFTALKQVLQELNFEYCPIDVELTESCLIEND
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHCCCC
ELALSVIQQFSRLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQVFVRDIHKQPVSQSLV
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHH
RAIVAVAQALNLQVIAEGVESAKEDAFLTKNGINERQGFLFAKPMPAVAFERWYKRYLKR
HHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]