The gene/protein map for NC_011745 is currently unavailable.
Definition Escherichia coli ED1a chromosome, complete genome.
Accession NC_011745
Length 5,209,548

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The map label for this gene is yciK [H]

Identifier: 218689261

GI number: 218689261

Start: 1448694

End: 1449452

Strand: Reverse

Name: yciK [H]

Synonym: ECED1_1477

Alternate gene names: 218689261

Gene position: 1449452-1448694 (Counterclockwise)

Preceding gene: 218689263

Following gene: 218689260

Centisome position: 27.82

GC content: 52.44

Gene sequence:

>759_bases
ATGCATTACCAGCCAAAACAAGATTTACTCAATGATCGCATTATCCTGGTGACGGGAGCCAGCGATGGAATTGGTCGTGA
AGCAGCGATGACGTATGCACGCTATGGTGCGACAGTGATTCTTTTGGGCCGTAATGAAGAAAAATTACGTCAGGTAGCCA
GCCACATAAACGAAGAAATTGGACGTCAGCCACAGTGGTTTATTCTCGATTTGCTAACCTGCACGTCCGAAGATTGCCAA
CAACTGGCACAGCGCATTGCCGTTAATTATCCGCGTCTGGATGGTGTTTTGCATAATGCCGGATTGCTCGGCGATGTTTG
CCCAATGAGCGAACAAGATCCGCAGGTCTGGCAGGACGTCATGCAGGTCAACGTTAATGCCACCTTTATGCTCACACAGG
CACTGCTTCCTTTATTACTCAAATCGGATGCCGGTTCACTGGTCTTTACCTCATCAAGCGTTGGACGTCAGGGGCGTGCA
AACTGGGGCGCATATGCAGCGTCGAAATTTGCCACCGAAGGGATGATGCAGGTACTGGCCGATGAATATCAGCAGCGCCT
GCGCGTCAACTGCATTAACCCAGGCGGTACGCGCACCGCAATGCGGGCCAGCGCCTTCCCGACCGAAGATCCACAGAAAC
TTAAAACCCCCGCTGATATCATGCCGCTCTACCTCTGGCTGATGGGCGATGACAGCCGCCGTAAAACCGGCATGACCTTT
GACGCCCAACCGGGCCGTAAACCAGGAATTTCCCAATGA

Upstream 100 bases:

>100_bases
CGCCCCAGGCTGATTGAAATGCCCTTCTGTTTCAGGCATAAAGCCCCAAAGTCATAAAGTACACTGGCAGCGCGACAGAC
AACGTCGTTGAGGAGTAGCC

Downstream 100 bases:

>100_bases
GTGATGAACGCTACCAACAGCGTCAGCAGCGAGTGAAAGAAAAAGTAGATGCTCGTGTGGCCCAGGCCCAGGATGAACGC
GGTATTATCATCGTCTTTAC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEEIGRQPQWFILDLLTCTSEDCQ
QLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQDPQVWQDVMQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ

Sequences:

>Translated_252_residues
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEEIGRQPQWFILDLLTCTSEDCQ
QLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQDPQVWQDVMQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ
>Mature_252_residues
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEEIGRQPQWFILDLLTCTSEDCQ
QLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQDPQVWQDVMQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRA
NWGAYAASKFATEGMMQVLADEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
DAQPGRKPGISQ

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI142976729, Length=222, Percent_Identity=27.9279279279279, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4504505, Length=238, Percent_Identity=28.1512605042017, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI20149619, Length=206, Percent_Identity=31.0679611650485, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI32455239, Length=206, Percent_Identity=33.9805825242718, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI5031765, Length=206, Percent_Identity=33.9805825242718, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI32483357, Length=252, Percent_Identity=26.1904761904762, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI66933014, Length=248, Percent_Identity=29.8387096774194, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI5031737, Length=201, Percent_Identity=27.8606965174129, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI7657478, Length=222, Percent_Identity=29.2792792792793, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI40807363, Length=207, Percent_Identity=25.6038647342995, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=29.0566037735849, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI210032110, Length=186, Percent_Identity=25.2688172043011, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI7705855, Length=206, Percent_Identity=26.6990291262136, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI10190704, Length=189, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI59889578, Length=171, Percent_Identity=30.9941520467836, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4503817, Length=182, Percent_Identity=28.021978021978, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI126723191, Length=199, Percent_Identity=26.1306532663317, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI7705925, Length=251, Percent_Identity=25.8964143426295, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI40254992, Length=192, Percent_Identity=26.5625, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=98.8095238095238, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=28.5123966942149, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789378, Length=239, Percent_Identity=32.6359832635983, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082100, Length=249, Percent_Identity=30.5220883534137, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=250, Percent_Identity=28.4, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786701, Length=205, Percent_Identity=29.2682926829268, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790717, Length=196, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787820, Length=224, Percent_Identity=22.7678571428571, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786812, Length=208, Percent_Identity=24.5192307692308, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=211, Percent_Identity=28.436018957346, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997402, Length=253, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=199, Percent_Identity=30.6532663316583, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=221, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=202, Percent_Identity=33.6633663366337, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=28.4, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17570069, Length=203, Percent_Identity=28.0788177339901, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=206, Percent_Identity=30.5825242718447, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=234, Percent_Identity=28.6324786324786, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=212, Percent_Identity=27.3584905660377, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=190, Percent_Identity=30, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=27.0588235294118, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=245, Percent_Identity=27.3469387755102, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=202, Percent_Identity=27.7227722772277, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=26.9076305220884, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=261, Percent_Identity=26.0536398467433, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=239, Percent_Identity=25.1046025104602, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=217, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=182, Percent_Identity=28.021978021978, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=199, Percent_Identity=30.1507537688442, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=191, Percent_Identity=28.2722513089005, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560176, Length=175, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=212, Percent_Identity=25.4716981132075, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=203, Percent_Identity=26.6009852216749, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=193, Percent_Identity=26.4248704663212, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=206, Percent_Identity=26.6990291262136, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=24.8995983935743, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=213, Percent_Identity=25.3521126760563, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=212, Percent_Identity=28.3018867924528, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=217, Percent_Identity=26.7281105990783, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322227, Length=215, Percent_Identity=30.6976744186047, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323882, Length=229, Percent_Identity=29.6943231441048, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322861, Length=238, Percent_Identity=26.0504201680672, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322226, Length=196, Percent_Identity=27.5510204081633, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=28.9156626506024, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI23397609, Length=187, Percent_Identity=33.1550802139037, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=28.1746031746032, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24640492, Length=182, Percent_Identity=30.2197802197802, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=27.9352226720648, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24643142, Length=205, Percent_Identity=35.1219512195122, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358495, Length=209, Percent_Identity=29.6650717703349, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281364892, Length=207, Percent_Identity=29.951690821256, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357041, Length=187, Percent_Identity=29.9465240641711, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=27.5590551181102, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859837, Length=223, Percent_Identity=28.6995515695067, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574402, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584744, Length=198, Percent_Identity=28.2828282828283, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24647931, Length=231, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27947; Mature: 27947

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEEI
CCCCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHH
GRQPQWFILDLLTCTSEDCQQLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQDPQVWQDV
CCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
MQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
HHHHHHHEEEEECCCCCCHHHCCCCCCCCCHHHHCCCHHHHHEEHEEECCCCCCCCCCEE
DAQPGRKPGISQ
CCCCCCCCCCCC
>Mature Secondary Structure
MHYQPKQDLLNDRIILVTGASDGIGREAAMTYARYGATVILLGRNEEKLRQVASHINEEI
CCCCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHH
GRQPQWFILDLLTCTSEDCQQLAQRIAVNYPRLDGVLHNAGLLGDVCPMSEQDPQVWQDV
CCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
MQVNVNATFMLTQALLPLLLKSDAGSLVFTSSSVGRQGRANWGAYAASKFATEGMMQVLA
HHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DEYQQRLRVNCINPGGTRTAMRASAFPTEDPQKLKTPADIMPLYLWLMGDDSRRKTGMTF
HHHHHHHEEEEECCCCCCHHHCCCCCCCCCHHHHCCCHHHHHEEHEEECCCCCCCCCCEE
DAQPGRKPGISQ
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on the CH-OH group of donors; With NAD or NADP as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 1885549 [H]