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The map label for this gene is ndh [H]

Identifier: 218689061

GI number: 218689061

Start: 1252065

End: 1253369

Strand: Direct

Name: ndh [H]

Synonym: ECED1_1252

Alternate gene names: 218689061

Gene position: 1252065-1253369 (Clockwise)

Preceding gene: 218689060

Following gene: 218689062

Centisome position: 24.03

GC content: 52.64

Gene sequence:

>1305_bases
TTGACTACGCCATTGAAAAAAATTGTGATTGTCGGCGGCGGTGCTGGTGGGCTGGAAATGGCAACACAGCTGGGGCATAA
GCTGGGACGCAAGAAAAAAGCCAAAATTACGCTGGTCGATCGTAACCACAGCCACCTGTGGAAACCGCTGCTGCACGAAG
TGGCGACTGGCTCGCTTGATGAAGGCGTCGATGCGTTGAGCTATCTGGCCCATGCGCGCAATCATGGTTTCCAGTTCCAG
CTGGGTTCCGTAATTGATATTGATCGTGAAGCGAAAACAATCACTATTGCAGAACTGCGCGACGAGAAAGGTGAACTGCT
GGTTCCGGAACGTAAAATCGCCTATGACACCCTGGTAATGGCGCTGGGTAGCACCTCTAACGATTTCAATACACCAGGTG
TCAAAGAGAACTGCATTTTCCTCGATAACCCGCACCAGGCGCGTCGCTTCCACCAGGAGATGCTGAATCTGTTCCTGAAA
TACTCCGCCAACCTGGGCGCGAATGGCAAAGTAAACATTGCGATTGTCGGCGGCGGCGCGACGGGTGTAGAACTCTCCGC
TGAATTGCACAACGCGGTCAAGCAACTGCACAGTTACGGTTATAAAGGTCTGACCAACGAAGCCCTGAACGTAACGCTGG
TAGAAGCGGGCGAACGTATTTTGCCTGCATTGCCGCCACGTATCTCTGCTGCGGCCCATAGTGAGTTAACGAAACTAGGC
GTTCGCGTGCTGACGCAAACCATGGTCACCAGTGCTGATGAAGGCGGCCTGCACACTAAAGATGGCGAATATATTGAGGC
TGATCTGATGGTGTGGGCAGCCGGGATCAAAGCGCCAGACTTCCTGAAAGATATCGGTGGTCTTGAAACCAACCGTATCA
ACCAGCTGGTGGTGGAACCGACGCTGCAAACCACTCGCGATCCAGACATATACGCTATTGGCGACTGCGCGTCATGCCCG
CGTCCGGAAGGGGGCTTTGTTCCGCCGCGCGCTCAGGCCGCACATCAGATGGCAACCTGCGCAATGAACAACATTCTGGC
GCAGATGAACGGTAAGCCGCTGAAAAATTATCAGTATAAAGATCACGGTTCGCTGGTATCGCTGTCGAACTTTTCCACCG
TCGGTAGCCTGATGGGTAACCTGACACGCGGCTCAATGATGATTGAAGGACGAATTGCGCGCTTTGTATACATCTCGCTG
TACCGAATGCACCAGATTGCGCTGCATGGTTACTTTAAAACCGGATTAATGATGCTGGTGGGGAGTATTAACCGCGTTAT
CCGTCCACGTTTGAAGTTGCATTAA

Upstream 100 bases:

>100_bases
AATAGCGAAGAACATTTTCATTGCTGTAACCTGTTGTTAATTAAGAGCTATGCTAATAACCATTAATTAACAATTGGTTA
ATAAATTTAAGGGGGTCACG

Downstream 100 bases:

>100_bases
TCGGCTTGTACTGGCGGATGCGGCGTAAACGCCTTATCCGCCCTGGACAAATGGTACGAGCGGTAGGCCTGATAAGACGC
GTTAAGCGTCGCATCAGGCA

Product: respiratory NADH dehydrogenase 2/cupric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTTPLKKIVIVGGGAGGLEMATQLGHKLGRKKKAKITLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFQFQ
LGSVIDIDREAKTITIAELRDEKGELLVPERKIAYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLK
YSANLGANGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISAAAHSELTKLG
VRVLTQTMVTSADEGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEPTLQTTRDPDIYAIGDCASCP
RPEGGFVPPRAQAAHQMATCAMNNILAQMNGKPLKNYQYKDHGSLVSLSNFSTVGSLMGNLTRGSMMIEGRIARFVYISL
YRMHQIALHGYFKTGLMMLVGSINRVIRPRLKLH

Sequences:

>Translated_434_residues
MTTPLKKIVIVGGGAGGLEMATQLGHKLGRKKKAKITLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFQFQ
LGSVIDIDREAKTITIAELRDEKGELLVPERKIAYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLK
YSANLGANGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISAAAHSELTKLG
VRVLTQTMVTSADEGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEPTLQTTRDPDIYAIGDCASCP
RPEGGFVPPRAQAAHQMATCAMNNILAQMNGKPLKNYQYKDHGSLVSLSNFSTVGSLMGNLTRGSMMIEGRIARFVYISL
YRMHQIALHGYFKTGLMMLVGSINRVIRPRLKLH
>Mature_433_residues
TTPLKKIVIVGGGAGGLEMATQLGHKLGRKKKAKITLVDRNHSHLWKPLLHEVATGSLDEGVDALSYLAHARNHGFQFQL
GSVIDIDREAKTITIAELRDEKGELLVPERKIAYDTLVMALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKY
SANLGANGKVNIAIVGGGATGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISAAAHSELTKLGV
RVLTQTMVTSADEGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEPTLQTTRDPDIYAIGDCASCPR
PEGGFVPPRAQAAHQMATCAMNNILAQMNGKPLKNYQYKDHGSLVSLSNFSTVGSLMGNLTRGSMMIEGRIARFVYISLY
RMHQIALHGYFKTGLMMLVGSINRVIRPRLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=434, Percent_Identity=99.7695852534562, Blast_Score=895, Evalue=0.0,
Organism=Escherichia coli, GI1789065, Length=358, Percent_Identity=26.536312849162, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323515, Length=464, Percent_Identity=26.2931034482759, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320118, Length=349, Percent_Identity=26.3610315186246, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323794, Length=349, Percent_Identity=28.3667621776504, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47332; Mature: 47201

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLKKIVIVGGGAGGLEMATQLGHKLGRKKKAKITLVDRNHSHLWKPLLHEVATGSLD
CCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHH
EGVDALSYLAHARNHGFQFQLGSVIDIDREAKTITIAELRDEKGELLVPERKIAYDTLVM
HHHHHHHHHHHHHCCCCEEECCCEEECCCCCCEEEEEECCCCCCCEECCCHHHHHHHHHH
ALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKYSANLGANGKVNIAIVGGGA
HHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
TGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISAAAHSELTKLG
CCEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHCCCCCCCCHHHHHHHHHHHH
VRVLTQTMVTSADEGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEP
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHCCCCCCCCCEEEECC
TLQTTRDPDIYAIGDCASCPRPEGGFVPPRAQAAHQMATCAMNNILAQMNGKPLKNYQYK
CHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DHGSLVSLSNFSTVGSLMGNLTRGSMMIEGRIARFVYISLYRMHQIALHGYFKTGLMMLV
CCCCEEEECCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSINRVIRPRLKLH
HHHHHHHCCHHCCC
>Mature Secondary Structure 
TTPLKKIVIVGGGAGGLEMATQLGHKLGRKKKAKITLVDRNHSHLWKPLLHEVATGSLD
CCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHH
EGVDALSYLAHARNHGFQFQLGSVIDIDREAKTITIAELRDEKGELLVPERKIAYDTLVM
HHHHHHHHHHHHHCCCCEEECCCEEECCCCCCEEEEEECCCCCCCEECCCHHHHHHHHHH
ALGSTSNDFNTPGVKENCIFLDNPHQARRFHQEMLNLFLKYSANLGANGKVNIAIVGGGA
HHCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCC
TGVELSAELHNAVKQLHSYGYKGLTNEALNVTLVEAGERILPALPPRISAAAHSELTKLG
CCEEEHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHCCCCCCCCHHHHHHHHHHHH
VRVLTQTMVTSADEGGLHTKDGEYIEADLMVWAAGIKAPDFLKDIGGLETNRINQLVVEP
HHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHCCCCCCCCCEEEECC
TLQTTRDPDIYAIGDCASCPRPEGGFVPPRAQAAHQMATCAMNNILAQMNGKPLKNYQYK
CHHCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DHGSLVSLSNFSTVGSLMGNLTRGSMMIEGRIARFVYISLYRMHQIALHGYFKTGLMMLV
CCCCEEEECCHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSINRVIRPRLKLH
HHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]