Click here to switch to the map view.

The map label for this gene is lpxK [H]

Identifier: 218688755

GI number: 218688755

Start: 971635

End: 972621

Strand: Direct

Name: lpxK [H]

Synonym: ECED1_0942

Alternate gene names: 218688755

Gene position: 971635-972621 (Clockwise)

Preceding gene: 218688754

Following gene: 218688756

Centisome position: 18.65

GC content: 54.91

Gene sequence:

>987_bases
ATGATCGAAAAAATCTGGTCTGGTGAATCCCCTTTATGGCGGCTATTGCTGCCACTCTCCTGGTTGTATGGCCTGGTGAG
TGGCGCGATCCGTCTTTGCTATAAACTAAAACTGAAGCGCGCCTGGCGTGCCCCCATACCGGTTGTCGTGGTTGGTAATC
TCACCGCAGGCGGCAACGGAAAAACCCCGGTCGTTGTCTGGCTGGTGGAACAGCTGCAACAGCGCGGTATTCGCGTGGGG
GTTGTATCGCGGGGATATGGTGGTAAGGCTGAATCTTATCCGCTGTTATTGTCGGCAGATACCACCACAGCACAGGCGGG
TGATGAACCTGTGTTGATTTATCAACGCACTGGCGCACCTGTTGCGGTTTCTCCCGTGCGTTCTGACGCGGTAAAAGCCA
TTCTGGCGCAACACCCTGATGTGCAGATCATCGTAACCGACGATGGTTTACAGCATTATCGTCTGGCGCGTGATGTGGAA
ATTGTCGTTATTGATGGTGTGCGTCGCTTTGGCAATGGCTGGTGGTTGCCGGCGGGGCCAATGCGTGAGCGAGCGGGGCG
CTTAAAGTCGGTTGATGCGGTAATCGTCAACGGCGGTGTCCCCCGCAGCGGTGAAATCCCCATGCATCTGCTGCCGGGTC
AGGCGGTGAATTTACGTACCGGTACGCGTTGTGACGTTGCTCAGCTTGAACATGTGGTGACGATTGCGGGGATTGGGCAT
CCGCCGCGCTTTTTTGCCACGCTGAAGATGTGCGGCGTACAACCGGAAAAATGTGTACCGCTGGCCGATCATCAGTCTTT
GAATCATGCGGATGTCAGCGCGTTGGTAAGCGCCGGACAAACGCTGGTAATGACTGAAAAAGATGCGGTGAAATGCCGGG
CCTTTGCAGAAGAAAATTGGTGGTATTTGCCTGTAGACGCACAGCTTTCAGGTGATGAACTAGCGAAACTGCTTGCGCAA
CTAACCTCGCTGGCTTCTGGCCACTAG

Upstream 100 bases:

>100_bases
TGGTTGTCGAGGATGGTGTCATTGTGGAACGCGGTACGCATAACGATTTGCTTGAGCACCGTGGCGTTTACGCGCAACTT
CACAAAATGCAGTTTGGCCA

Downstream 100 bases:

>100_bases
TTACGCCGCGGCAGCGTTCGATTGATGGAGTCATGAATGTCGCTGCCGCACCTCTCCCTTGCTGATGCGCGTAATCTTCA
CCTTGCCGCGCAAGGCCTGT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPIPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGIRVG
VVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTGAPVAVSPVRSDAVKAILAQHPDVQIIVTDDGLQHYRLARDVE
IVVIDGVRRFGNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVTIAGIGH
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWWYLPVDAQLSGDELAKLLAQ
LTSLASGH

Sequences:

>Translated_328_residues
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPIPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGIRVG
VVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTGAPVAVSPVRSDAVKAILAQHPDVQIIVTDDGLQHYRLARDVE
IVVIDGVRRFGNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVTIAGIGH
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWWYLPVDAQLSGDELAKLLAQ
LTSLASGH
>Mature_328_residues
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPIPVVVVGNLTAGGNGKTPVVVWLVEQLQQRGIRVG
VVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTGAPVAVSPVRSDAVKAILAQHPDVQIIVTDDGLQHYRLARDVE
IVVIDGVRRFGNGWWLPAGPMRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVTIAGIGH
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENWWYLPVDAQLSGDELAKLLAQ
LTSLASGH

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=328, Percent_Identity=97.5609756097561, Blast_Score=647, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 35541; Mature: 35541

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPIPVVVVGNLTAGGNG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEECCCCC
KTPVVVWLVEQLQQRGIRVGVVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTGAP
CCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCC
VAVSPVRSDAVKAILAQHPDVQIIVTDDGLQHYRLARDVEIVVIDGVRRFGNGWWLPAGP
EEECCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCEEEEEEECHHHHCCCCCCCCCH
MRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVTIAGIGH
HHHHCCCCCCCCEEEEECCCCCCCCCCEEECCCCEEECCCCCCCCHHHHHEEEEEEECCC
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENW
CHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCHHEEEEEECCCC
WYLPVDAQLSGDELAKLLAQLTSLASGH
EEEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIEKIWSGESPLWRLLLPLSWLYGLVSGAIRLCYKLKLKRAWRAPIPVVVVGNLTAGGNG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECEECCCCC
KTPVVVWLVEQLQQRGIRVGVVSRGYGGKAESYPLLLSADTTTAQAGDEPVLIYQRTGAP
CCCEEEHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCC
VAVSPVRSDAVKAILAQHPDVQIIVTDDGLQHYRLARDVEIVVIDGVRRFGNGWWLPAGP
EEECCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCCEEEEEEECHHHHCCCCCCCCCH
MRERAGRLKSVDAVIVNGGVPRSGEIPMHLLPGQAVNLRTGTRCDVAQLEHVVTIAGIGH
HHHHCCCCCCCCEEEEECCCCCCCCCCEEECCCCEEECCCCCCCCHHHHHEEEEEEECCC
PPRFFATLKMCGVQPEKCVPLADHQSLNHADVSALVSAGQTLVMTEKDAVKCRAFAEENW
CHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCHHEEEEEECCCC
WYLPVDAQLSGDELAKLLAQLTSLASGH
EEEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA