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The map label for this gene is aarA [H]

Identifier: 218688472

GI number: 218688472

Start: 666816

End: 668693

Strand: Direct

Name: aarA [H]

Synonym: ECED1_0646

Alternate gene names: 218688472

Gene position: 666816-668693 (Clockwise)

Preceding gene: 218688466

Following gene: 218688473

Centisome position: 12.8

GC content: 49.73

Gene sequence:

>1878_bases
ATGTCTGCATCTTCGGTTAAGCCGTTAAATGTTCAATTACCCGCAATAACCCTGATCCTTTTTGCGCTCTGTGTTGGGAT
ATTTTGTTACCTCGCACAATGGATGAGTTATGAAGAAGTCGATCAATCCGCACTCATCCATCTCGGCGCTAACGTTGCTT
CTCTCACGTTGTCGGATGAATCCTGGCGCTTATTGAGCAGTGTTTTTCTGCACAGTAGTTTTTCCCATTTGCTGATGAAT
ATGTTTGCACTCCTGGTGGTGGGGACAGTGGCGGAACGGATACTGGGGAAATGGCGACTCCTGATTATCTGGTTATTCTC
CGGCATCTTTGGTGGGCTGATCAGCGCCTGTTATGCGTTACGCGAAAGTGAGCAGATAGTCATCAGCGTTGGGGCATCCG
GGGCAATTATGGGAATAGCGGGCGCTGCGATAGCAACACAGCTTGCTTCAGGTGCGGGCACACACCATAAAAACCAGCGG
CGAGTATTTCCTCTGTTGGGTATGGTGGCGCTGACACTGTTGTATGGTACCCGGCAAGCAGGAATAGATAACGCTTGCCA
CATTGGCGGCCTGATTGCGGGGGGCGCGTTGGGTTGGCTGAGCGCGCGTTTAGTTGGGCAAAACCGATTCGTTACGGAAG
GCGGGATTATTGTTGCGGTCACTCTTCTTCTGACCGGGGCTATCTGGCTTGTGCAGCAGCAGATTGATGAATCAGTTTTA
CAGGTCAGGCAAAGCCTGCGTGAAGCGTTTTATCCGCAGGAGATTGAACAAGAGCGACGACAAAAAAAGCAGCAGTTAGT
GGAGGAGCGCAACGCCCTCACGGAAACATTATCCGCTCCGGTAAGTCGTGAGCAGGCCAGTGGTGATTTACTCGCTGAGA
TTGCCGATATCCATGATATGGCGATCAGTCGGGATGGTAATACGTTGTATGCCGCAATTGAAAACACGAACAGCATTGTT
GTTTTCGACCTCGGACAAAAGAAAATCCTGCATACCTTTACAGCGCCCATAGCGAAAGAAAAGTCAGTCAAACATTGTGG
TGGCTGTAAAGATCAGGGCGTCAGATCGCTGGCATTAAGCCTGGATGAAAAGTTGATTTATGCGACTTCATTTGAAGCGA
ATGCGTTATCGGTCATTAACGTGGCGACGGGGGAGATTATTCAGTCGATTACCACCGGCGCACATCCTGACAGCTTTATC
CTCTCGCGTGATGGCACAAAAGCCTGGGTGATGAATCGCACCAGTAATAGTGTGTCAGCGATTGATCTGGTGGCTTATCA
GCATGTGGCGGATATCCCGCTGGAGAAATACGACGGGACGGGGATGAGCGGTAAACCAGGCGCCTGGGTTATGGCACTTT
CCCCGGATGAAAAAACATTACTGGTTCCGGGAGCAGGCAGAGGTAACATCGTGCGGATCAATACCATCACGCATCAGAAA
GAAGACTTTCCCGCAGGTAATGCGCGTGGTGTCGTTTCTGCGATGGGATTCCGACCAAAAAATGGTGAGATTATTTTTGC
CGATAGCCAGGGGATTTCACGTATAAGAGCTGAGGATCAACAAGCCAGCATTATGACGCAATGGTGTAGCAGGAGCGTTT
ATTCCGTTGAGGGTATTAGCCCGGACGGTCAGTATTTAGCGTTGGTGTCATATGGCCTGCAAGGTTATGTCATCCTGCTC
AATATTAATGCCGGGCAGATTATTGGCGTTTATCCCGCCAGCTACGTGAATCATCTTCGTTTTTCAGCGGATGATAGAAA
GATATTTGTTATGGCGAAGAACAGGTTAATCCAAATGGACAGGACGCGCTCGCTTGATCCGCAGGCAATTATTCGGCATC
CCCAATATGGCGATGTGGCTTGTATCCCTGAACCGTAA

Upstream 100 bases:

>100_bases
TTTCAGACAGTGTTAACTTTTCGGTGTGGGACGTTTGCCGGGATGATAACTACACTCGGGAAAATGCTTTTTACTAGTCT
TTTCAAGGAAGAATCACCTT

Downstream 100 bases:

>100_bases
GAAAAAAGGGCATGATAATCATGCCCCAGAGCGTGTTGAAAAAGTACGCTTTATCCTACAAAATCGCGAAAATTCAACAT
ATTGTAAAAATCGCGTAGGC

Product: hypothetical protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MSASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEVDQSALIHLGANVASLTLSDESWRLLSSVFLHSSFSHLLMN
MFALLVVGTVAERILGKWRLLIIWLFSGIFGGLISACYALRESEQIVISVGASGAIMGIAGAAIATQLASGAGTHHKNQR
RVFPLLGMVALTLLYGTRQAGIDNACHIGGLIAGGALGWLSARLVGQNRFVTEGGIIVAVTLLLTGAIWLVQQQIDESVL
QVRQSLREAFYPQEIEQERRQKKQQLVEERNALTETLSAPVSREQASGDLLAEIADIHDMAISRDGNTLYAAIENTNSIV
VFDLGQKKILHTFTAPIAKEKSVKHCGGCKDQGVRSLALSLDEKLIYATSFEANALSVINVATGEIIQSITTGAHPDSFI
LSRDGTKAWVMNRTSNSVSAIDLVAYQHVADIPLEKYDGTGMSGKPGAWVMALSPDEKTLLVPGAGRGNIVRINTITHQK
EDFPAGNARGVVSAMGFRPKNGEIIFADSQGISRIRAEDQQASIMTQWCSRSVYSVEGISPDGQYLALVSYGLQGYVILL
NINAGQIIGVYPASYVNHLRFSADDRKIFVMAKNRLIQMDRTRSLDPQAIIRHPQYGDVACIPEP

Sequences:

>Translated_625_residues
MSASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEVDQSALIHLGANVASLTLSDESWRLLSSVFLHSSFSHLLMN
MFALLVVGTVAERILGKWRLLIIWLFSGIFGGLISACYALRESEQIVISVGASGAIMGIAGAAIATQLASGAGTHHKNQR
RVFPLLGMVALTLLYGTRQAGIDNACHIGGLIAGGALGWLSARLVGQNRFVTEGGIIVAVTLLLTGAIWLVQQQIDESVL
QVRQSLREAFYPQEIEQERRQKKQQLVEERNALTETLSAPVSREQASGDLLAEIADIHDMAISRDGNTLYAAIENTNSIV
VFDLGQKKILHTFTAPIAKEKSVKHCGGCKDQGVRSLALSLDEKLIYATSFEANALSVINVATGEIIQSITTGAHPDSFI
LSRDGTKAWVMNRTSNSVSAIDLVAYQHVADIPLEKYDGTGMSGKPGAWVMALSPDEKTLLVPGAGRGNIVRINTITHQK
EDFPAGNARGVVSAMGFRPKNGEIIFADSQGISRIRAEDQQASIMTQWCSRSVYSVEGISPDGQYLALVSYGLQGYVILL
NINAGQIIGVYPASYVNHLRFSADDRKIFVMAKNRLIQMDRTRSLDPQAIIRHPQYGDVACIPEP
>Mature_624_residues
SASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEVDQSALIHLGANVASLTLSDESWRLLSSVFLHSSFSHLLMNM
FALLVVGTVAERILGKWRLLIIWLFSGIFGGLISACYALRESEQIVISVGASGAIMGIAGAAIATQLASGAGTHHKNQRR
VFPLLGMVALTLLYGTRQAGIDNACHIGGLIAGGALGWLSARLVGQNRFVTEGGIIVAVTLLLTGAIWLVQQQIDESVLQ
VRQSLREAFYPQEIEQERRQKKQQLVEERNALTETLSAPVSREQASGDLLAEIADIHDMAISRDGNTLYAAIENTNSIVV
FDLGQKKILHTFTAPIAKEKSVKHCGGCKDQGVRSLALSLDEKLIYATSFEANALSVINVATGEIIQSITTGAHPDSFIL
SRDGTKAWVMNRTSNSVSAIDLVAYQHVADIPLEKYDGTGMSGKPGAWVMALSPDEKTLLVPGAGRGNIVRINTITHQKE
DFPAGNARGVVSAMGFRPKNGEIIFADSQGISRIRAEDQQASIMTQWCSRSVYSVEGISPDGQYLALVSYGLQGYVILLN
INAGQIIGVYPASYVNHLRFSADDRKIFVMAKNRLIQMDRTRSLDPQAIIRHPQYGDVACIPEP

Specific function: Rhomboid serine protease that catalyzes intramembrane proteolysis. Mediates quorum-sensing and the subsequent regulation of target genes via activation of the Tat protein export system. Catalyzes the proteolytic activation of tatA by removal of its N- ter

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S54 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764 [H]

Pfam domain/function: PF01694 Rhomboid [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 67779; Mature: 67648

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEVDQSALIHLGANVASLTLSDE
CCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHEEECCCEEEEEECCH
SWRLLSSVFLHSSFSHLLMNMFALLVVGTVAERILGKWRLLIIWLFSGIFGGLISACYAL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RESEQIVISVGASGAIMGIAGAAIATQLASGAGTHHKNQRRVFPLLGMVALTLLYGTRQA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHC
GIDNACHIGGLIAGGALGWLSARLVGQNRFVTEGGIIVAVTLLLTGAIWLVQQQIDESVL
CCCCCHHHCCHHHCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVRQSLREAFYPQEIEQERRQKKQQLVEERNALTETLSAPVSREQASGDLLAEIADIHDM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHH
AISRDGNTLYAAIENTNSIVVFDLGQKKILHTFTAPIAKEKSVKHCGGCKDQGVRSLALS
HEECCCCEEEEEEECCCEEEEEECCCCHHHHHHHCCHHCCCCCHHCCCCCHHHHHHHHHH
LDEKLIYATSFEANALSVINVATGEIIQSITTGAHPDSFILSRDGTKAWVMNRTSNSVSA
HCCEEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCHH
IDLVAYQHVADIPLEKYDGTGMSGKPGAWVMALSPDEKTLLVPGAGRGNIVRINTITHQK
HHHHHHHHHHCCCCHHCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCEEEEEEEECCC
EDFPAGNARGVVSAMGFRPKNGEIIFADSQGISRIRAEDQQASIMTQWCSRSVYSVEGIS
CCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCHHHHCCHHHHHHHHHHHCCCEEEECCCC
PDGQYLALVSYGLQGYVILLNINAGQIIGVYPASYVNHLRFSADDRKIFVMAKNRLIQMD
CCCCEEEEEEECCCEEEEEEECCCCCEEEECCHHHHHHHEECCCCCEEEEEECCCEEEEC
RTRSLDPQAIIRHPQYGDVACIPEP
CCCCCCHHHHHCCCCCCCEEECCCC
>Mature Secondary Structure 
SASSVKPLNVQLPAITLILFALCVGIFCYLAQWMSYEEVDQSALIHLGANVASLTLSDE
CCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHEEECCCEEEEEECCH
SWRLLSSVFLHSSFSHLLMNMFALLVVGTVAERILGKWRLLIIWLFSGIFGGLISACYAL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RESEQIVISVGASGAIMGIAGAAIATQLASGAGTHHKNQRRVFPLLGMVALTLLYGTRQA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHC
GIDNACHIGGLIAGGALGWLSARLVGQNRFVTEGGIIVAVTLLLTGAIWLVQQQIDESVL
CCCCCHHHCCHHHCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVRQSLREAFYPQEIEQERRQKKQQLVEERNALTETLSAPVSREQASGDLLAEIADIHDM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHH
AISRDGNTLYAAIENTNSIVVFDLGQKKILHTFTAPIAKEKSVKHCGGCKDQGVRSLALS
HEECCCCEEEEEEECCCEEEEEECCCCHHHHHHHCCHHCCCCCHHCCCCCHHHHHHHHHH
LDEKLIYATSFEANALSVINVATGEIIQSITTGAHPDSFILSRDGTKAWVMNRTSNSVSA
HCCEEEEEECCCCCCEEEEEEHHHHHHHHHHCCCCCCCEEEECCCCEEEEEECCCCCCHH
IDLVAYQHVADIPLEKYDGTGMSGKPGAWVMALSPDEKTLLVPGAGRGNIVRINTITHQK
HHHHHHHHHHCCCCHHCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCEEEEEEEECCC
EDFPAGNARGVVSAMGFRPKNGEIIFADSQGISRIRAEDQQASIMTQWCSRSVYSVEGIS
CCCCCCCCCCHHHHHCCCCCCCCEEEECCCCCHHHHCCHHHHHHHHHHHCCCEEEECCCC
PDGQYLALVSYGLQGYVILLNINAGQIIGVYPASYVNHLRFSADDRKIFVMAKNRLIQMD
CCCCEEEEEEECCCEEEEEEECCCCCEEEECCHHHHHHHEECCCCCEEEEEECCCEEEEC
RTRSLDPQAIIRHPQYGDVACIPEP
CCCCCCHHHHHCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8051030 [H]