| Definition | Escherichia coli ED1a chromosome, complete genome. |
|---|---|
| Accession | NC_011745 |
| Length | 5,209,548 |
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The map label for this gene is ytbE [H]
Identifier: 218688182
GI number: 218688182
Start: 353155
End: 353931
Strand: Direct
Name: ytbE [H]
Synonym: ECED1_0339
Alternate gene names: 218688182
Gene position: 353155-353931 (Clockwise)
Preceding gene: 218688181
Following gene: 218688186
Centisome position: 6.78
GC content: 43.37
Gene sequence:
>777_bases GTGTTGAATGCTATCCGCACGGGTTATCGACTCATCGACACTGCAGCGGTATACGGTAATGAAGATGCCGTCGGTGAAGC CGTTCGTGAAGCCATATCTGAAGGTTTATGTACCCGAGAAGAGTTATTTATAACGTCTAAATTGTGGGTGCAGGATATGT TGAATCAGGATATTGCAGCAGCAGGTATTGAAGCATCATTAAAAAAATCGGGGCTAGAATACTTCGATCTCTATTTATTG CACCAGGCCATGCGCGATTATTTTAGTGCGTGGCGTGCACTCGAAGATGCCTATGAAGAGGGCAAATTAAAAGCGATTGG GGTTTCCAATTTCTACCCTCATGTTCTGGCGAACTTTTGTGAAACGGTAAGAGTTAAACCGATGGTCAACCAGGTCGAGT TGCATCCCTATTTTGCCCAACCAGAGGCGCTGGCAACCATGAAGTATTATAACGTGCAGCCTGAAGCATGGGCTCCGTTA GGTGGTGGACGACATAAACCCTTTGAAAATAATCTGCTTCAGAGTATTGCAGATGCCCATCAAAAATCGATTTCTCAGGT CATTCTGCGTTGGAATATTCAACGGGGAGTGGTCGTTATTCCGAAATCGACACATCAACAGCGTATCGAAGAAAATTTTG CTATTTGGGATTTCTCACTGACAGAGAAAGAAATGGCTCAAATTAGTTCGCTTGATTTGGGTTATGTTGGGGAATCGGTA AAACATTTTAATCCTGAGTTTGTTCGTGGTTGTCTTGCTGTAAAAATACATGATTGA
Upstream 100 bases:
>100_bases ATGTTTTCTTCTCGAGCAACTTCTTTAAACAGATGGTGAACCTCGGGATCAGCGATATCAACACCAAAGATCTATTCAAC TTTCGCTTTCAGAACAGTCA
Downstream 100 bases:
>100_bases TATTAATCACTTATTTTACCTGAGACGACAAGAATCTTTTAATAGGGGAGTGATATTGACCTTCACTCTGTCATATCTCC GGTAATATGGCGTCAGGCTT
Product: putative reductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 258; Mature: 258
Protein sequence:
>258_residues MLNAIRTGYRLIDTAAVYGNEDAVGEAVREAISEGLCTREELFITSKLWVQDMLNQDIAAAGIEASLKKSGLEYFDLYLL HQAMRDYFSAWRALEDAYEEGKLKAIGVSNFYPHVLANFCETVRVKPMVNQVELHPYFAQPEALATMKYYNVQPEAWAPL GGGRHKPFENNLLQSIADAHQKSISQVILRWNIQRGVVVIPKSTHQQRIEENFAIWDFSLTEKEMAQISSLDLGYVGESV KHFNPEFVRGCLAVKIHD
Sequences:
>Translated_258_residues MLNAIRTGYRLIDTAAVYGNEDAVGEAVREAISEGLCTREELFITSKLWVQDMLNQDIAAAGIEASLKKSGLEYFDLYLL HQAMRDYFSAWRALEDAYEEGKLKAIGVSNFYPHVLANFCETVRVKPMVNQVELHPYFAQPEALATMKYYNVQPEAWAPL GGGRHKPFENNLLQSIADAHQKSISQVILRWNIQRGVVVIPKSTHQQRIEENFAIWDFSLTEKEMAQISSLDLGYVGESV KHFNPEFVRGCLAVKIHD >Mature_258_residues MLNAIRTGYRLIDTAAVYGNEDAVGEAVREAISEGLCTREELFITSKLWVQDMLNQDIAAAGIEASLKKSGLEYFDLYLL HQAMRDYFSAWRALEDAYEEGKLKAIGVSNFYPHVLANFCETVRVKPMVNQVELHPYFAQPEALATMKYYNVQPEAWAPL GGGRHKPFENNLLQSIADAHQKSISQVILRWNIQRGVVVIPKSTHQQRIEENFAIWDFSLTEKEMAQISSLDLGYVGESV KHFNPEFVRGCLAVKIHD
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI5174695, Length=261, Percent_Identity=39.0804597701149, Blast_Score=171, Evalue=5e-43, Organism=Homo sapiens, GI223468663, Length=260, Percent_Identity=37.3076923076923, Blast_Score=159, Evalue=3e-39, Organism=Homo sapiens, GI24497577, Length=259, Percent_Identity=35.5212355212355, Blast_Score=156, Evalue=2e-38, Organism=Homo sapiens, GI5174391, Length=259, Percent_Identity=35.5212355212355, Blast_Score=156, Evalue=2e-38, Organism=Homo sapiens, GI310109922, Length=240, Percent_Identity=37.0833333333333, Blast_Score=155, Evalue=2e-38, Organism=Homo sapiens, GI24497583, Length=261, Percent_Identity=35.2490421455939, Blast_Score=155, Evalue=3e-38, Organism=Homo sapiens, GI310109920, Length=261, Percent_Identity=34.8659003831418, Blast_Score=154, Evalue=1e-37, Organism=Homo sapiens, GI24497585, Length=264, Percent_Identity=36.3636363636364, Blast_Score=154, Evalue=1e-37, Organism=Homo sapiens, GI5453543, Length=261, Percent_Identity=34.8659003831418, Blast_Score=152, Evalue=2e-37, Organism=Homo sapiens, GI45446745, Length=261, Percent_Identity=34.8659003831418, Blast_Score=152, Evalue=2e-37, Organism=Homo sapiens, GI4503285, Length=261, Percent_Identity=34.8659003831418, Blast_Score=152, Evalue=2e-37, Organism=Homo sapiens, GI300116271, Length=241, Percent_Identity=38.5892116182573, Blast_Score=151, Evalue=6e-37, Organism=Homo sapiens, GI300116273, Length=244, Percent_Identity=37.2950819672131, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI291291012, Length=272, Percent_Identity=34.9264705882353, Blast_Score=150, Evalue=1e-36, Organism=Homo sapiens, GI93277124, Length=273, Percent_Identity=33.6996336996337, Blast_Score=147, Evalue=9e-36, Organism=Homo sapiens, GI4502049, Length=260, Percent_Identity=34.2307692307692, Blast_Score=135, Evalue=3e-32, Organism=Homo sapiens, GI310109924, Length=150, Percent_Identity=35.3333333333333, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI310109926, Length=78, Percent_Identity=44.8717948717949, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI207028673, Length=78, Percent_Identity=44.8717948717949, Blast_Score=70, Evalue=2e-12, Organism=Escherichia coli, GI87082198, Length=234, Percent_Identity=41.025641025641, Blast_Score=186, Evalue=2e-48, Organism=Escherichia coli, GI1786400, Length=252, Percent_Identity=31.7460317460317, Blast_Score=119, Evalue=3e-28, Organism=Escherichia coli, GI1788081, Length=242, Percent_Identity=31.8181818181818, Blast_Score=81, Evalue=6e-17, Organism=Escherichia coli, GI48994888, Length=256, Percent_Identity=26.171875, Blast_Score=66, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17550248, Length=256, Percent_Identity=37.109375, Blast_Score=156, Evalue=8e-39, Organism=Caenorhabditis elegans, GI17537077, Length=255, Percent_Identity=37.2549019607843, Blast_Score=154, Evalue=3e-38, Organism=Caenorhabditis elegans, GI17564128, Length=263, Percent_Identity=35.361216730038, Blast_Score=152, Evalue=1e-37, Organism=Caenorhabditis elegans, GI17537075, Length=258, Percent_Identity=36.4341085271318, Blast_Score=149, Evalue=1e-36, Organism=Caenorhabditis elegans, GI71998625, Length=235, Percent_Identity=34.468085106383, Blast_Score=141, Evalue=3e-34, Organism=Caenorhabditis elegans, GI17566692, Length=253, Percent_Identity=33.201581027668, Blast_Score=136, Evalue=9e-33, Organism=Caenorhabditis elegans, GI17561298, Length=245, Percent_Identity=31.4285714285714, Blast_Score=127, Evalue=4e-30, Organism=Caenorhabditis elegans, GI17538386, Length=243, Percent_Identity=29.2181069958848, Blast_Score=119, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17537079, Length=268, Percent_Identity=29.1044776119403, Blast_Score=114, Evalue=6e-26, Organism=Caenorhabditis elegans, GI17552492, Length=243, Percent_Identity=29.2181069958848, Blast_Score=111, Evalue=4e-25, Organism=Caenorhabditis elegans, GI17562292, Length=247, Percent_Identity=26.7206477732794, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17561300, Length=243, Percent_Identity=28.3950617283951, Blast_Score=101, Evalue=4e-22, Organism=Saccharomyces cerevisiae, GI6321896, Length=274, Percent_Identity=34.6715328467153, Blast_Score=161, Evalue=7e-41, Organism=Saccharomyces cerevisiae, GI6324694, Length=275, Percent_Identity=31.2727272727273, Blast_Score=140, Evalue=2e-34, Organism=Saccharomyces cerevisiae, GI6320576, Length=262, Percent_Identity=32.4427480916031, Blast_Score=140, Evalue=3e-34, Organism=Saccharomyces cerevisiae, GI6322556, Length=237, Percent_Identity=34.5991561181435, Blast_Score=130, Evalue=2e-31, Organism=Saccharomyces cerevisiae, GI6319625, Length=284, Percent_Identity=30.9859154929577, Blast_Score=124, Evalue=1e-29, Organism=Saccharomyces cerevisiae, GI6320079, Length=238, Percent_Identity=33.1932773109244, Blast_Score=116, Evalue=4e-27, Organism=Drosophila melanogaster, GI24662789, Length=264, Percent_Identity=37.8787878787879, Blast_Score=169, Evalue=2e-42, Organism=Drosophila melanogaster, GI24657054, Length=272, Percent_Identity=37.5, Blast_Score=168, Evalue=3e-42, Organism=Drosophila melanogaster, GI21356425, Length=263, Percent_Identity=36.5019011406844, Blast_Score=160, Evalue=6e-40, Organism=Drosophila melanogaster, GI24663317, Length=270, Percent_Identity=35.1851851851852, Blast_Score=150, Evalue=8e-37, Organism=Drosophila melanogaster, GI20129731, Length=280, Percent_Identity=33.9285714285714, Blast_Score=147, Evalue=6e-36, Organism=Drosophila melanogaster, GI24644950, Length=266, Percent_Identity=33.4586466165414, Blast_Score=145, Evalue=3e-35, Organism=Drosophila melanogaster, GI24662785, Length=259, Percent_Identity=35.5212355212355, Blast_Score=138, Evalue=3e-33, Organism=Drosophila melanogaster, GI24662781, Length=259, Percent_Identity=35.5212355212355, Blast_Score=138, Evalue=4e-33, Organism=Drosophila melanogaster, GI221378297, Length=286, Percent_Identity=31.1188811188811, Blast_Score=137, Evalue=6e-33, Organism=Drosophila melanogaster, GI45553081, Length=260, Percent_Identity=29.6153846153846, Blast_Score=131, Evalue=5e-31, Organism=Drosophila melanogaster, GI281366140, Length=255, Percent_Identity=29.8039215686275, Blast_Score=129, Evalue=2e-30,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: NA
Molecular weight: Translated: 29255; Mature: 29255
Theoretical pI: Translated: 5.60; Mature: 5.60
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00063 ALDOKETO_REDUCTASE_3
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLNAIRTGYRLIDTAAVYGNEDAVGEAVREAISEGLCTREELFITSKLWVQDMLNQDIAA CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHH AGIEASLKKSGLEYFDLYLLHQAMRDYFSAWRALEDAYEEGKLKAIGVSNFYPHVLANFC HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH ETVRVKPMVNQVELHPYFAQPEALATMKYYNVQPEAWAPLGGGRHKPFENNLLQSIADAH HHHCCCCCHHHEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH QKSISQVILRWNIQRGVVVIPKSTHQQRIEENFAIWDFSLTEKEMAQISSLDLGYVGESV HHHHHHHHHHEECCCCEEEECCCHHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHHCCHH KHFNPEFVRGCLAVKIHD HHCCHHHHHCEEEEEECC >Mature Secondary Structure MLNAIRTGYRLIDTAAVYGNEDAVGEAVREAISEGLCTREELFITSKLWVQDMLNQDIAA CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHH AGIEASLKKSGLEYFDLYLLHQAMRDYFSAWRALEDAYEEGKLKAIGVSNFYPHVLANFC HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH ETVRVKPMVNQVELHPYFAQPEALATMKYYNVQPEAWAPLGGGRHKPFENNLLQSIADAH HHHCCCCCHHHEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH QKSISQVILRWNIQRGVVVIPKSTHQQRIEENFAIWDFSLTEKEMAQISSLDLGYVGESV HHHHHHHHHHEECCCCEEEECCCHHHHHHHCCCEEEEECCCHHHHHHHHCCCHHHHCCHH KHFNPEFVRGCLAVKIHD HHCCHHHHHCEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377 [H]