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The map label for this gene is mutH [H]

Identifier: 218550079

GI number: 218550079

Start: 2829795

End: 2830499

Strand: Direct

Name: mutH [H]

Synonym: EFER_2764

Alternate gene names: 218550079

Gene position: 2829795-2830499 (Clockwise)

Preceding gene: 218550066

Following gene: 218550080

Centisome position: 61.67

GC content: 53.33

Gene sequence:

>705_bases
TTGAATAGTATGCCCGACATCCGCCCTCTTCTTACATCCCCTGCCTCAGAAGCTGAATTACTTGCTCAGGCACAGCAGCT
CTCTGGCTATACCTTAGGGGAGTTGGCAGCCCTTGCCGGGATGGTAACGCCCAAAGATTTAAAGCGGGATAAAGGCTGGA
TTGGTGTTCTGCTGGAGATCTGGCTGGGGGCCAGCGCAGGGAGCAAACCGGAACAGGATTTCGCCGCACTGGGAGTCGAG
CTAAAAACAATTCCGGTGGACAGTCTTGGTCGTCCGCTGGAAACCACATTTGTTTGTGTCGCGCCATTAACCGGAAACAC
GGGGGTTACCTGGGAAACCAGCCACGTGCGACACAAACTAAAACGCGTCCTGTGGATACCTGTCGAAGGTGAACGAAGCA
TTCCCCTTGCGCAACGGCGTGTGGGTTCACCATTGTTATGGAGCCCAAATGAAGAAGAAGATCGCCAGCTACGTCTCGAC
TGGGAAGAACTGATGGATATGATCGTGCTGGGTCGGGTAGAGCGTATCACCGCCCGGCATGGTGAAGTTTTACAGCTGCG
ACCGAAAGCAGCCAACGCTAAAGCCCTGACCGAAGCCATTGGCGCTAATGGCGAACCGATTTTAACGTTACCCCGCGGTT
TCTACCTGAAAAAGAATTTCACCAGTGCATTACTGGCCCGTCATTTTCTGATCCAGCAGCCATAA

Upstream 100 bases:

>100_bases
AGATAAAAAATCATATAAATCATAGCATTGAATATCTCTCAGGGAAAAATATACACTCTGTACACCCGGTATAAAATTGC
TGTTTGTTTTTTAATCAAGG

Downstream 100 bases:

>100_bases
CTTTGATCTGCCGAATTCCGGGCATATAATTATCGCTTCATTTTTTTTGGCAGGGCTTTTTAGATGTTATTTGCATGGAT
CACCGATCCTAACGCCTGGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MNSMPDIRPLLTSPASEAELLAQAQQLSGYTLGELAALAGMVTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVE
LKTIPVDSLGRPLETTFVCVAPLTGNTGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLRLD
WEELMDMIVLGRVERITARHGEVLQLRPKAANAKALTEAIGANGEPILTLPRGFYLKKNFTSALLARHFLIQQP

Sequences:

>Translated_234_residues
MNSMPDIRPLLTSPASEAELLAQAQQLSGYTLGELAALAGMVTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVE
LKTIPVDSLGRPLETTFVCVAPLTGNTGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLRLD
WEELMDMIVLGRVERITARHGEVLQLRPKAANAKALTEAIGANGEPILTLPRGFYLKKNFTSALLARHFLIQQP
>Mature_234_residues
MNSMPDIRPLLTSPASEAELLAQAQQLSGYTLGELAALAGMVTPKDLKRDKGWIGVLLEIWLGASAGSKPEQDFAALGVE
LKTIPVDSLGRPLETTFVCVAPLTGNTGVTWETSHVRHKLKRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLRLD
WEELMDMIVLGRVERITARHGEVLQLRPKAANAKALTEAIGANGEPILTLPRGFYLKKNFTSALLARHFLIQQP

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=229, Percent_Identity=91.2663755458515, Blast_Score=421, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 25824; Mature: 25824

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSMPDIRPLLTSPASEAELLAQAQQLSGYTLGELAALAGMVTPKDLKRDKGWIGVLLEI
CCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHH
WLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNTGVTWETSHVRHKL
HHCCCCCCCCHHHHHHHCCEEEEECHHHCCCCCCEEEEEEEECCCCCCCEEEHHHHHHHH
KRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLRLDWEELMDMIVLGRVERITARH
HHEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCC
GEVLQLRPKAANAKALTEAIGANGEPILTLPRGFYLKKNFTSALLARHFLIQQP
CCEEEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSMPDIRPLLTSPASEAELLAQAQQLSGYTLGELAALAGMVTPKDLKRDKGWIGVLLEI
CCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHH
WLGASAGSKPEQDFAALGVELKTIPVDSLGRPLETTFVCVAPLTGNTGVTWETSHVRHKL
HHCCCCCCCCHHHHHHHCCEEEEECHHHCCCCCCEEEEEEEECCCCCCCEEEHHHHHHHH
KRVLWIPVEGERSIPLAQRRVGSPLLWSPNEEEDRQLRLDWEELMDMIVLGRVERITARH
HHEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCC
GEVLQLRPKAANAKALTEAIGANGEPILTLPRGFYLKKNFTSALLARHFLIQQP
CCEEEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA