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The map label for this gene is ampH [H]

Identifier: 218549962

GI number: 218549962

Start: 2717029

End: 2718195

Strand: Direct

Name: ampH [H]

Synonym: EFER_2647

Alternate gene names: 218549962

Gene position: 2717029-2718195 (Clockwise)

Preceding gene: 218549959

Following gene: 218549965

Centisome position: 59.21

GC content: 51.07

Gene sequence:

>1167_bases
ATGCCGCTTTTGAAACGTAGTCTGCTTTTGTCTGCCGCCTTGTGCGCTGTCTTCATTACCCCAGCCCAGGCGGTGCAGCC
CATCGCCGATCCACAATTTGCCTCAGATATTGTTGATCGTTACGCCGAACATATTTTTTATGGCAGTGGCGCAACAGGAA
TGGCGCTGGTTGTAATCGACGGTAACCAACGCGTATTTCGTAGTTTTGGTGAAACGCGCCCTGGCAACAACGTTCGCCCG
CAGCTGGACTCCGTGATTCGTATTGCCTCAATCACCAAACTGATGACCAGTGAGATGCTGGTGAAGTTGCTTGATCAAGG
TACCGTAAAATTAAACGATCCGCTAAGTAAATATGCTCCACCGGGTGCCCGTGTTCCAACTTACCAGGGAACGCCTATTA
CACTGGTTAACCTGGCGACACATACCAGTGCCCTGCCCCGCGAGCAACCAGGTGGTGCAGCGAATCGCCCGGTTTTCGTC
TGGCCGACGCGTGAGCAACGCTGGAGCTACCTTTCTGGAGCCAAATTGAAAGCAGCTCCAGGTTCGCAGGCTGCATACTC
TAATCTGGCATACGACCTGTTGGCGGATGCTCTCTCAACTGCCGCCGGGCGGCCTTATAGCCAGCTGTTTGAAGAGAAAA
TTACCCGTCCGTTAGGTATGAAAGACACCACTTTTACGCCTTCGCCTGATCAATGTAAGCGTCTGATGGTTGCGGAACGA
GGTGCCAGCCCATGTAATAACACGCTGGCCGCTGTGGGAAGTGGCGGTGTCTATTCCACACCAGGCGACATGATGCGTTG
GATGCAGCAGTATCTTTCATCTGACTTTTATCAACGCAGTAAACAGGCTGACCGCATGCAAACATTGATTTTTCAGCGTG
CGCAGTTAACGAAAGTCATTGGTATGGATGTGCCAGGTAAAGCGGATGCTTTAGGGCTTGGTTGGGTTTATATGGCACCG
AAAGAGGGTCGCCCAGGAATCATTCAAAAAACCGGTGGCGGTGGTGGTTTTATCACTTATATGGCGATGATTCCGCAGCA
AAACGTCGGCGCTTTTGTGGTCGTCACGCGCTCTGCTCAGACTCGTTTTAAAAATATGAGCGATGGCATTAATGATTTGG
TAACAGAGTTGAGCGAGAATAAGCAACTTGTTATTCCCGCTTCCTGA

Upstream 100 bases:

>100_bases
CCATCGTTACGTTTTAAGCCGTGTCGTTGCACAATTAAGCGTTTTGCAACCAGCAGCCGAATAGTATAAATACGCTATAT
GATTTTTATTTGATCCATGG

Downstream 100 bases:

>100_bases
TTAATACTCAGAAGGCAAGCGGTTGATTTTGACCAGTTTGCCTTTATTCATTTCGATGTATTCGCCTTTACGTAATGCTG
CAAGGACTTCTGCAACAACA

Product: beta-lactam binding protein AmpH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MPLLKRSLLLSAALCAVFITPAQAVQPIADPQFASDIVDRYAEHIFYGSGATGMALVVIDGNQRVFRSFGETRPGNNVRP
QLDSVIRIASITKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYQGTPITLVNLATHTSALPREQPGGAANRPVFV
WPTREQRWSYLSGAKLKAAPGSQAAYSNLAYDLLADALSTAAGRPYSQLFEEKITRPLGMKDTTFTPSPDQCKRLMVAER
GASPCNNTLAAVGSGGVYSTPGDMMRWMQQYLSSDFYQRSKQADRMQTLIFQRAQLTKVIGMDVPGKADALGLGWVYMAP
KEGRPGIIQKTGGGGGFITYMAMIPQQNVGAFVVVTRSAQTRFKNMSDGINDLVTELSENKQLVIPAS

Sequences:

>Translated_388_residues
MPLLKRSLLLSAALCAVFITPAQAVQPIADPQFASDIVDRYAEHIFYGSGATGMALVVIDGNQRVFRSFGETRPGNNVRP
QLDSVIRIASITKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYQGTPITLVNLATHTSALPREQPGGAANRPVFV
WPTREQRWSYLSGAKLKAAPGSQAAYSNLAYDLLADALSTAAGRPYSQLFEEKITRPLGMKDTTFTPSPDQCKRLMVAER
GASPCNNTLAAVGSGGVYSTPGDMMRWMQQYLSSDFYQRSKQADRMQTLIFQRAQLTKVIGMDVPGKADALGLGWVYMAP
KEGRPGIIQKTGGGGGFITYMAMIPQQNVGAFVVVTRSAQTRFKNMSDGINDLVTELSENKQLVIPAS
>Mature_387_residues
PLLKRSLLLSAALCAVFITPAQAVQPIADPQFASDIVDRYAEHIFYGSGATGMALVVIDGNQRVFRSFGETRPGNNVRPQ
LDSVIRIASITKLMTSEMLVKLLDQGTVKLNDPLSKYAPPGARVPTYQGTPITLVNLATHTSALPREQPGGAANRPVFVW
PTREQRWSYLSGAKLKAAPGSQAAYSNLAYDLLADALSTAAGRPYSQLFEEKITRPLGMKDTTFTPSPDQCKRLMVAERG
ASPCNNTLAAVGSGGVYSTPGDMMRWMQQYLSSDFYQRSKQADRMQTLIFQRAQLTKVIGMDVPGKADALGLGWVYMAPK
EGRPGIIQKTGGGGGFITYMAMIPQQNVGAFVVVTRSAQTRFKNMSDGINDLVTELSENKQLVIPAS

Specific function: Binds penicillin and contributes to the normal morphology [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI239747261, Length=364, Percent_Identity=26.6483516483516, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI239752721, Length=364, Percent_Identity=26.6483516483516, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI239741085, Length=364, Percent_Identity=26.6483516483516, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI1786574, Length=385, Percent_Identity=89.6103896103896, Blast_Score=726, Evalue=0.0,
Organism=Escherichia coli, GI1790593, Length=372, Percent_Identity=23.6559139784946, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082101, Length=246, Percent_Identity=26.4227642276423, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: NA

Molecular weight: Translated: 42074; Mature: 41943

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLKRSLLLSAALCAVFITPAQAVQPIADPQFASDIVDRYAEHIFYGSGATGMALVVID
CCHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCEEEEEEC
GNQRVFRSFGETRPGNNVRPQLDSVIRIASITKLMTSEMLVKLLDQGTVKLNDPLSKYAP
CCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCC
PGARVPTYQGTPITLVNLATHTSALPREQPGGAANRPVFVWPTREQRWSYLSGAKLKAAP
CCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCEEECCC
GSQAAYSNLAYDLLADALSTAAGRPYSQLFEEKITRPLGMKDTTFTPSPDQCKRLMVAER
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHC
GASPCNNTLAAVGSGGVYSTPGDMMRWMQQYLSSDFYQRSKQADRMQTLIFQRAQLTKVI
CCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQQNVGAFVVVTRSAQ
CCCCCCCCCCEEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCEEEEEECCHH
TRFKNMSDGINDLVTELSENKQLVIPAS
HHHHHHHCCHHHHHHHHCCCCEEEEECC
>Mature Secondary Structure 
PLLKRSLLLSAALCAVFITPAQAVQPIADPQFASDIVDRYAEHIFYGSGATGMALVVID
CHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHEEECCCCCCEEEEEEC
GNQRVFRSFGETRPGNNVRPQLDSVIRIASITKLMTSEMLVKLLDQGTVKLNDPLSKYAP
CCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHCC
PGARVPTYQGTPITLVNLATHTSALPREQPGGAANRPVFVWPTREQRWSYLSGAKLKAAP
CCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCEEEECCHHHHHHHHCCCEEECCC
GSQAAYSNLAYDLLADALSTAAGRPYSQLFEEKITRPLGMKDTTFTPSPDQCKRLMVAER
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHC
GASPCNNTLAAVGSGGVYSTPGDMMRWMQQYLSSDFYQRSKQADRMQTLIFQRAQLTKVI
CCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMDVPGKADALGLGWVYMAPKEGRPGIIQKTGGGGGFITYMAMIPQQNVGAFVVVTRSAQ
CCCCCCCCCCEEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHCCCCCCCEEEEEECCHH
TRFKNMSDGINDLVTELSENKQLVIPAS
HHHHHHHCCHHHHHHHHCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]