BacMap

Definition	Escherichia fergusonii ATCC 35469 chromosome, complete genome.
Accession	NC_011740
Length	4,588,711

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The map label for this gene is yxbG [H]

Identifier: 218549840

GI number: 218549840

Start: 2589950

End: 2590768

Strand: Direct

Name: yxbG [H]

Synonym: EFER_2523

Alternate gene names: 218549840

Gene position: 2589950-2590768 (Clockwise)

Preceding gene: 218549839

Following gene: 218549844

Centisome position: 56.44

GC content: 50.79

Gene sequence:

>819_bases
ATGCCCCTGCGGGCTCATAAAAGAGATATCAAAATGATCGCAAAAGATTTTGCTCAACAATTGTTTGATCTCCACGATCG
CGTCGCCTTTGTCACTGGCGCAGGTAGCGGTATCGGACAAATGATCGCTCTGGCTTTTGCCAGCGCAGGCGCACGAGTGG
TGTGTTTTGATCTACGGGAAGATGGCGGACTTAAAGAGACGGTTAATCATATCGAAGCACTTGGTGGACAAGCCTTGTAT
TACACGGGCGATGTTCGGGAGTTGAGAGATCTTCGCTCAGCAGTCGCTCTGGCAAAAACACATTTTGGTCGTCTGGATAT
TGCCGTAAACGCCGCTGGAATCGCTAACGCGAACCCGGCGCTGGAAATGGAAAGCGAGCAATGGCAACGCGTTATAGATA
TCAACCTGACTGGTGTGTGGAATTCCTGTAAGGCGGAAGCCGAGTTAATGGTAGAGAACGGAGGCGGTTCGATTATAAAT
ATTGCGTCAATGTCCGGGATTATCGTCAATCGCGGTCTGGAACAGGCCCACTACAACAGCTCCAAAGCAGGCGTGATTCA
TTTATCTAAAAGTCTTGCGATGGAATGGGTGAGTAATGGGATCCGCGTGAACTCAATCAGCCCAGGATATACCGCGACAC
CAATGAATACCCGACCTGAAATGGTGCATCAGACACGGGAGTTTGAAAGCCAGACGCCGATTCAACGGATGGCGAAAGTG
GAAGAGATGGCGGGCCCAGCGCTGTTCCTTGCCAGCGATGCGGCGTCATTCTGCACTGGTGTTGATCTGGTGGTCGATGG
TGGTTTTATCTGCTGGTAA

Upstream 100 bases:

>100_bases
CTGAAGATGTTGCCGGACTGGTTGCCTTCCTCGCCTCTGACGATGCGCGTTATCTCACCGGTCAAACCATCAACATCGAC
GGCGGCCTGATTATGTCGTA

Downstream 100 bases:

>100_bases
AAATGGTTTCGCCCGCAGCCATCACTGACCGCGGGCGAAAGTGTAAAGCAGGTGCCTTACCATCCTGACCTGACAACCGG
ATATGCGGGGATTACTCCCC

Product: short chain dehydrogenase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPLRAHKRDIKMIAKDFAQQLFDLHDRVAFVTGAGSGIGQMIALAFASAGARVVCFDLREDGGLKETVNHIEALGGQALY
YTGDVRELRDLRSAVALAKTHFGRLDIAVNAAGIANANPALEMESEQWQRVIDINLTGVWNSCKAEAELMVENGGGSIIN
IASMSGIIVNRGLEQAHYNSSKAGVIHLSKSLAMEWVSNGIRVNSISPGYTATPMNTRPEMVHQTREFESQTPIQRMAKV
EEMAGPALFLASDAASFCTGVDLVVDGGFICW

Sequences:

>Translated_272_residues
MPLRAHKRDIKMIAKDFAQQLFDLHDRVAFVTGAGSGIGQMIALAFASAGARVVCFDLREDGGLKETVNHIEALGGQALY
YTGDVRELRDLRSAVALAKTHFGRLDIAVNAAGIANANPALEMESEQWQRVIDINLTGVWNSCKAEAELMVENGGGSIIN
IASMSGIIVNRGLEQAHYNSSKAGVIHLSKSLAMEWVSNGIRVNSISPGYTATPMNTRPEMVHQTREFESQTPIQRMAKV
EEMAGPALFLASDAASFCTGVDLVVDGGFICW
>Mature_271_residues
PLRAHKRDIKMIAKDFAQQLFDLHDRVAFVTGAGSGIGQMIALAFASAGARVVCFDLREDGGLKETVNHIEALGGQALYY
TGDVRELRDLRSAVALAKTHFGRLDIAVNAAGIANANPALEMESEQWQRVIDINLTGVWNSCKAEAELMVENGGGSIINI
ASMSGIIVNRGLEQAHYNSSKAGVIHLSKSLAMEWVSNGIRVNSISPGYTATPMNTRPEMVHQTREFESQTPIQRMAKVE
EMAGPALFLASDAASFCTGVDLVVDGGFICW

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=35.9848484848485, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI10190704, Length=250, Percent_Identity=35.6, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI40254992, Length=244, Percent_Identity=31.5573770491803, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4758504, Length=231, Percent_Identity=36.3636363636364, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=32.2834645669291, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=35.0649350649351, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=32.0158102766798, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI66933014, Length=256, Percent_Identity=29.6875, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI83715985, Length=186, Percent_Identity=35.4838709677419, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI4504505, Length=190, Percent_Identity=37.3684210526316, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI31542939, Length=230, Percent_Identity=31.304347826087, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI7705925, Length=256, Percent_Identity=30.46875, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI126723750, Length=255, Percent_Identity=30.5882352941176, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI5031737, Length=258, Percent_Identity=29.0697674418605, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI142976729, Length=196, Percent_Identity=26.0204081632653, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI224922801, Length=181, Percent_Identity=32.5966850828729, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4503301, Length=259, Percent_Identity=30.1158301158301, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI310128830, Length=199, Percent_Identity=25.6281407035176, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI310115468, Length=199, Percent_Identity=25.6281407035176, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI40807363, Length=193, Percent_Identity=27.4611398963731, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI109715829, Length=201, Percent_Identity=29.8507462686567, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI25282469, Length=217, Percent_Identity=28.110599078341, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI126723191, Length=190, Percent_Identity=30, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI33667109, Length=200, Percent_Identity=30, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI210032110, Length=196, Percent_Identity=26.0204081632653, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=35.5731225296443, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI87082100, Length=252, Percent_Identity=36.1111111111111, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=36.2903225806452, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=35.1020408163265, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=31.7829457364341, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=32.258064516129, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=30.3149606299213, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786812, Length=260, Percent_Identity=31.9230769230769, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=30.6122448979592, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789378, Length=239, Percent_Identity=31.3807531380753, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789057, Length=264, Percent_Identity=28.7878787878788, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367365, Length=243, Percent_Identity=28.8065843621399, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787526, Length=253, Percent_Identity=26.4822134387352, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787820, Length=184, Percent_Identity=31.5217391304348, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=38.1526104417671, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=36.2903225806452, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI193203115, Length=195, Percent_Identity=32.8205128205128, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI193203117, Length=191, Percent_Identity=32.9842931937173, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115534694, Length=254, Percent_Identity=33.4645669291339, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=31.4176245210728, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17564282, Length=192, Percent_Identity=31.25, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17538182, Length=208, Percent_Identity=33.1730769230769, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=31.3953488372093, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=29.4573643410853, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=29.4820717131474, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=258, Percent_Identity=31.3953488372093, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=29.0836653386454, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17567345, Length=201, Percent_Identity=29.8507462686567, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17568967, Length=190, Percent_Identity=34.2105263157895, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=29.0816326530612, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=257, Percent_Identity=27.6264591439689, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=262, Percent_Identity=30.9160305343511, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17544670, Length=268, Percent_Identity=27.9850746268657, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=31.1023622047244, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=260, Percent_Identity=28.4615384615385, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=259, Percent_Identity=30.1158301158301, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=30.4182509505703, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=259, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=258, Percent_Identity=27.906976744186, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=27.7992277992278, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=258, Percent_Identity=29.4573643410853, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=27.6923076923077, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=258, Percent_Identity=24.4186046511628, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=25.0950570342205, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=28.6259541984733, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=256, Percent_Identity=25, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561272, Length=279, Percent_Identity=27.5985663082437, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=201, Percent_Identity=27.8606965174129, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=35.2331606217617, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324126, Length=253, Percent_Identity=29.2490118577075, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320089, Length=217, Percent_Identity=27.1889400921659, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=36, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=34.2629482071713, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=34.1269841269841, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21357041, Length=251, Percent_Identity=32.6693227091633, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=33.8582677165354, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI17737361, Length=237, Percent_Identity=34.1772151898734, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI18859837, Length=190, Percent_Identity=35.7894736842105, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24643142, Length=265, Percent_Identity=30.9433962264151, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21355319, Length=271, Percent_Identity=28.7822878228782, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644337, Length=254, Percent_Identity=31.1023622047244, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI281364892, Length=204, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640492, Length=207, Percent_Identity=27.536231884058, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24581726, Length=210, Percent_Identity=28.0952380952381, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24665243, Length=208, Percent_Identity=29.3269230769231, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221331218, Length=196, Percent_Identity=30.6122448979592, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24665247, Length=209, Percent_Identity=29.1866028708134, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221331216, Length=197, Percent_Identity=30.4568527918782, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21357673, Length=216, Percent_Identity=27.3148148148148, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 29367; Mature: 29236

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRAHKRDIKMIAKDFAQQLFDLHDRVAFVTGAGSGIGQMIALAFASAGARVVCFDLRE
CCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECC
DGGLKETVNHIEALGGQALYYTGDVRELRDLRSAVALAKTHFGRLDIAVNAAGIANANPA
CCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCC
LEMESEQWQRVIDINLTGVWNSCKAEAELMVENGGGSIINIASMSGIIVNRGLEQAHYNS
EEECHHHCCEEEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCHHHCCCHHHHCCC
SKAGVIHLSKSLAMEWVSNGIRVNSISPGYTATPMNTRPEMVHQTREFESQTPIQRMAKV
CCCEEEEEHHHHHHHHHHCCEEEECCCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHH
EEMAGPALFLASDAASFCTGVDLVVDGGFICW
HHHCCCEEEEECCHHHHHCCCEEEECCCEEEC
>Mature Secondary Structure 
PLRAHKRDIKMIAKDFAQQLFDLHDRVAFVTGAGSGIGQMIALAFASAGARVVCFDLRE
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECC
DGGLKETVNHIEALGGQALYYTGDVRELRDLRSAVALAKTHFGRLDIAVNAAGIANANPA
CCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCC
LEMESEQWQRVIDINLTGVWNSCKAEAELMVENGGGSIINIASMSGIIVNRGLEQAHYNS
EEECHHHCCEEEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCHHHCCCHHHHCCC
SKAGVIHLSKSLAMEWVSNGIRVNSISPGYTATPMNTRPEMVHQTREFESQTPIQRMAKV
CCCEEEEEHHHHHHHHHHCCEEEECCCCCCEECCCCCCHHHHHHHHHHCCCCHHHHHHHH
EEMAGPALFLASDAASFCTGVDLVVDGGFICW
HHHCCCEEEEECCHHHHHCCCEEEECCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]