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The map label for this gene is glpK2 [H]

Identifier: 218549834

GI number: 218549834

Start: 2583242

End: 2584762

Strand: Direct

Name: glpK2 [H]

Synonym: EFER_2517

Alternate gene names: 218549834

Gene position: 2583242-2584762 (Clockwise)

Preceding gene: 218549833

Following gene: 218549835

Centisome position: 56.3

GC content: 52.07

Gene sequence:

>1521_bases
ATGTTTGCAGGAAATAAAGAGTTCGTTATTGCGTTGGATGAGGGTACCACCAATGCAAAAGCCATCGCACTTGATGGTTT
CGGTAACGTGGTGGCGAAGTTTTCTCAACCACTTGCTATTCAGACGCCACGTGAAGGCTGGGTTGAGCAATCCGGGGAAG
CGTTAATCTCTGCCTCGCTTGACGTTATTGCCCAGGCCATCAGCCACGTGGGGGCAGAAAATGTAGCGGCTCTGGCTATC
AGTAATCAGCGTGAAACGGCTATCGGCTGGTATCGTCAGAGTGGAAAACCACTCAATGCGGCGATTACCTGGCAATGCAC
GCGCAGTGCAGAGTTTTGTGAAACACTTCGTCGCGAGGGCAAAGAGCAGCAAATTAAAACGACTACAGGCCTGCCTATCG
CCCCGCTATTTTCCGCTTTCAAGATGCGTTGGCTACTGGAATCTACATCTGAGGGTGTGCAACTTGCCGACCAGGGTGAA
ATTTGTCTCGGCACCATTGATGCCTGGTTACTATGGAACTTGACTGCTGGCGATTCATTTTGCTGCGACCACTCTAACGC
CGCGCGAACTCAATTACTTAACCTGAAAACAGGCGAGTGGGATGAGGAAATGCTGGCATTGTTTCATATTCCACGCGCTG
CATTGCCAGAAATTAAACCATCCAGTGGCCTGTTCGGTTATACCCGAGGGCTTAAAACAATTCCGGATGGTATTCCCGTC
ATGGCGATGGTGGGCGATTCTCACGCCGCTCTTTTTGGTCATGCGTTGGGAGAAGCGGGATGTGTGAAAGCGACCTATGG
GACCGGTTCTTCCGTCATGGCCCCCGTCAACTCTGCTCAGTGTGATATCGCCACACTTGCCACAACCATTGCCTGGCATG
ACGGCGAAAATATTGTTTACGGTCTGGAAGGAAATATCCCCCACACCGGGGATGCCGTGGCATGGATGGCTGATAGCACC
GGTTTAAGTGAACTGACAGACGCTGAGCTGGCCCACGAACTGAATACCCTGCCAGCCTCAGTGGATTCGACTATGGGCGT
TTATTTTGTTCCTGCTCTCACTGGCCTGGGCGCACCATGGTGGGATGACAGTGCTCGCGGCGTGGTGTGTGGCTTAAGCC
GTGGCGTAAAGCGCGCGCATTTGATTCGCGCCGCACTGGAATCAATCACTTACCAAATTGCAGATGTAGTAGAAGCCATG
CAACAGCATGATAATTTTCACTTATCGGCGTTAATGGTGGATGGCGGCCCGACCAAAAATGACTGGTTGATGCAATATCA
GGCGGATCTGCTGGGTTGCCCGGTGATGCGCAGTGATGTGCCAGAGCTTTCGGCCATTGGTGCGGGTCTGCTCGCCCGCA
AAGCGCTTACCCCCGGCACCGTTGCAGATTTAAAAACGTTATTAACTGAACACAGTGAATTTAAACCGGACATGGCGCGT
CATCAGCGACTGCAAAAGAGATGGCAGGAGTGGCGTCATGCGGTAAACAGAACATTATGGAAACCGGCATCGTCAATTTG
A

Upstream 100 bases:

>100_bases
ACAGAATGTCACAGCAGGGCCTGATGAAGTAATAACGTGACCATGAGGAACGCCTCATCTCCTTCCACGCCAGGATGCAA
TGTGACTCAGGAGACTACCT

Downstream 100 bases:

>100_bases
CGAACAAGACTAACCAACGGAAGGAGAATACCGGCCCATAAATAATTCAGGCTTTACGTTGTTTCACCGTACCAGACAAT
AACAACACAGAGAGAACATT

Product: glycerol kinase 2

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase 2; Glycerokinase 2; GK 2 [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MFAGNKEFVIALDEGTTNAKAIALDGFGNVVAKFSQPLAIQTPREGWVEQSGEALISASLDVIAQAISHVGAENVAALAI
SNQRETAIGWYRQSGKPLNAAITWQCTRSAEFCETLRREGKEQQIKTTTGLPIAPLFSAFKMRWLLESTSEGVQLADQGE
ICLGTIDAWLLWNLTAGDSFCCDHSNAARTQLLNLKTGEWDEEMLALFHIPRAALPEIKPSSGLFGYTRGLKTIPDGIPV
MAMVGDSHAALFGHALGEAGCVKATYGTGSSVMAPVNSAQCDIATLATTIAWHDGENIVYGLEGNIPHTGDAVAWMADST
GLSELTDAELAHELNTLPASVDSTMGVYFVPALTGLGAPWWDDSARGVVCGLSRGVKRAHLIRAALESITYQIADVVEAM
QQHDNFHLSALMVDGGPTKNDWLMQYQADLLGCPVMRSDVPELSAIGAGLLARKALTPGTVADLKTLLTEHSEFKPDMAR
HQRLQKRWQEWRHAVNRTLWKPASSI

Sequences:

>Translated_506_residues
MFAGNKEFVIALDEGTTNAKAIALDGFGNVVAKFSQPLAIQTPREGWVEQSGEALISASLDVIAQAISHVGAENVAALAI
SNQRETAIGWYRQSGKPLNAAITWQCTRSAEFCETLRREGKEQQIKTTTGLPIAPLFSAFKMRWLLESTSEGVQLADQGE
ICLGTIDAWLLWNLTAGDSFCCDHSNAARTQLLNLKTGEWDEEMLALFHIPRAALPEIKPSSGLFGYTRGLKTIPDGIPV
MAMVGDSHAALFGHALGEAGCVKATYGTGSSVMAPVNSAQCDIATLATTIAWHDGENIVYGLEGNIPHTGDAVAWMADST
GLSELTDAELAHELNTLPASVDSTMGVYFVPALTGLGAPWWDDSARGVVCGLSRGVKRAHLIRAALESITYQIADVVEAM
QQHDNFHLSALMVDGGPTKNDWLMQYQADLLGCPVMRSDVPELSAIGAGLLARKALTPGTVADLKTLLTEHSEFKPDMAR
HQRLQKRWQEWRHAVNRTLWKPASSI
>Mature_506_residues
MFAGNKEFVIALDEGTTNAKAIALDGFGNVVAKFSQPLAIQTPREGWVEQSGEALISASLDVIAQAISHVGAENVAALAI
SNQRETAIGWYRQSGKPLNAAITWQCTRSAEFCETLRREGKEQQIKTTTGLPIAPLFSAFKMRWLLESTSEGVQLADQGE
ICLGTIDAWLLWNLTAGDSFCCDHSNAARTQLLNLKTGEWDEEMLALFHIPRAALPEIKPSSGLFGYTRGLKTIPDGIPV
MAMVGDSHAALFGHALGEAGCVKATYGTGSSVMAPVNSAQCDIATLATTIAWHDGENIVYGLEGNIPHTGDAVAWMADST
GLSELTDAELAHELNTLPASVDSTMGVYFVPALTGLGAPWWDDSARGVVCGLSRGVKRAHLIRAALESITYQIADVVEAM
QQHDNFHLSALMVDGGPTKNDWLMQYQADLLGCPVMRSDVPELSAIGAGLLARKALTPGTVADLKTLLTEHSEFKPDMAR
HQRLQKRWQEWRHAVNRTLWKPASSI

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI42794763, Length=518, Percent_Identity=32.6254826254826, Blast_Score=289, Evalue=5e-78,
Organism=Homo sapiens, GI4504007, Length=514, Percent_Identity=32.8793774319066, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI189409120, Length=514, Percent_Identity=32.8793774319066, Blast_Score=288, Evalue=6e-78,
Organism=Homo sapiens, GI41393575, Length=514, Percent_Identity=32.295719844358, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI88196792, Length=513, Percent_Identity=29.2397660818713, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1790361, Length=504, Percent_Identity=39.484126984127, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1789168, Length=460, Percent_Identity=24.5652173913043, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1790005, Length=504, Percent_Identity=24.2063492063492, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789987, Length=512, Percent_Identity=26.5625, Blast_Score=92, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17535599, Length=509, Percent_Identity=31.041257367387, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71986140, Length=526, Percent_Identity=24.7148288973384, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71986147, Length=264, Percent_Identity=30.3030303030303, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6321755, Length=493, Percent_Identity=27.789046653144, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17864214, Length=522, Percent_Identity=34.0996168582375, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24654573, Length=450, Percent_Identity=34.8888888888889, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI24655555, Length=521, Percent_Identity=32.6295585412668, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24655560, Length=521, Percent_Identity=32.6295585412668, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24655570, Length=521, Percent_Identity=32.6295585412668, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24655574, Length=521, Percent_Identity=32.6295585412668, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24655565, Length=521, Percent_Identity=32.6295585412668, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI19922058, Length=494, Percent_Identity=27.5303643724696, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24652871, Length=492, Percent_Identity=27.6422764227642, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24656367, Length=512, Percent_Identity=27.1484375, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21357867, Length=526, Percent_Identity=26.615969581749, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24656372, Length=350, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45552909, Length=254, Percent_Identity=27.9527559055118, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 54620; Mature: 54620

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAGNKEFVIALDEGTTNAKAIALDGFGNVVAKFSQPLAIQTPREGWVEQSGEALISASL
CCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHCCCEEEECCCHHHHHCCCCHHHHHHH
DVIAQAISHVGAENVAALAISNQRETAIGWYRQSGKPLNAAITWQCTRSAEFCETLRREG
HHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHCC
KEQQIKTTTGLPIAPLFSAFKMRWLLESTSEGVQLADQGEICLGTIDAWLLWNLTAGDSF
CHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEECEEEEEEECCCCCC
CCDHSNAARTQLLNLKTGEWDEEMLALFHIPRAALPEIKPSSGLFGYTRGLKTIPDGIPV
CCCCCCHHHHEEEECCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCHHHCCCCCCCCCCCE
MAMVGDSHAALFGHALGEAGCVKATYGTGSSVMAPVNSAQCDIATLATTIAWHDGENIVY
EEEECCCHHHHHHHHHCCCCCEEEECCCCCCEECCCCCCCCHHHHHHHHHEEECCCEEEE
GLEGNIPHTGDAVAWMADSTGLSELTDAELAHELNTLPASVDSTMGVYFVPALTGLGAPW
EECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHCCCCC
WDDSARGVVCGLSRGVKRAHLIRAALESITYQIADVVEAMQQHDNFHLSALMVDGGPTKN
CCCCCCEEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
DWLMQYQADLLGCPVMRSDVPELSAIGAGLLARKALTPGTVADLKTLLTEHSEFKPDMAR
HHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
HQRLQKRWQEWRHAVNRTLWKPASSI
HHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFAGNKEFVIALDEGTTNAKAIALDGFGNVVAKFSQPLAIQTPREGWVEQSGEALISASL
CCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHCCCEEEECCCHHHHHCCCCHHHHHHH
DVIAQAISHVGAENVAALAISNQRETAIGWYRQSGKPLNAAITWQCTRSAEFCETLRREG
HHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHCC
KEQQIKTTTGLPIAPLFSAFKMRWLLESTSEGVQLADQGEICLGTIDAWLLWNLTAGDSF
CHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEECEEEEEEECCCCCC
CCDHSNAARTQLLNLKTGEWDEEMLALFHIPRAALPEIKPSSGLFGYTRGLKTIPDGIPV
CCCCCCHHHHEEEECCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCHHHCCCCCCCCCCCE
MAMVGDSHAALFGHALGEAGCVKATYGTGSSVMAPVNSAQCDIATLATTIAWHDGENIVY
EEEECCCHHHHHHHHHCCCCCEEEECCCCCCEECCCCCCCCHHHHHHHHHEEECCCEEEE
GLEGNIPHTGDAVAWMADSTGLSELTDAELAHELNTLPASVDSTMGVYFVPALTGLGAPW
EECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHCCCCC
WDDSARGVVCGLSRGVKRAHLIRAALESITYQIADVVEAMQQHDNFHLSALMVDGGPTKN
CCCCCCEEEEEHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
DWLMQYQADLLGCPVMRSDVPELSAIGAGLLARKALTPGTVADLKTLLTEHSEFKPDMAR
HHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHH
HQRLQKRWQEWRHAVNRTLWKPASSI
HHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]