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The map label for this gene is erg3 [H]

Identifier: 218549075

GI number: 218549075

Start: 1773922

End: 1775046

Strand: Reverse

Name: erg3 [H]

Synonym: EFER_1727

Alternate gene names: 218549075

Gene position: 1775046-1773922 (Counterclockwise)

Preceding gene: 218549076

Following gene: 218549074

Centisome position: 38.68

GC content: 49.6

Gene sequence:

>1125_bases
ATGAGTGATTTACTGTTTCCCATCATATCGATGGTGCTGTTAGTGTTAGCCGAAGCGGGCGTGTTGCAATTCACCGGGCG
GCAAAAAGTGGACTGGCTGGACGTTATTTTTAATATCAACTCCGGTCATATGATGCTGTGGTTATTTCGCTGCCTGGAAG
TGCTCTGCTATAGCCTGGTGGTCAATCACTTCAGCCTTGGACTGTTTGATAATGCGCCAGGGATCCTGCTGTGGCTATTT
ACAATCCTTGCGTGGGATTTCGGCTTTTACTGGCTGCATCGCTGGCATCACGAGATGCGCCCGCTGTGGGCGGTACATGT
GGTGCATCATCAGGGGGAACACTACAACCTCTCATTAGGTGTGCGGAACTCGTGGTACTCCTCGTTAACCTCAATCCCGT
TCTTTATGCTGCTGGCGATGCTTGGCGTGCCGTTGCAGGTCTTTTTGGCGGTTTCTATTATTCACTATAGTTGGCAATTT
TTTAACCATAACGCGCTAGCGCCGAAACTGGGTTGGCTGGAAAAAGTGCTGATCACGCCTTCGCATCATCGCGTCCATCA
TCTGAATGAAAAGCAATATGCCGATACCAATTACGGTGGCACCTTTTTGTTGTGGGATAAACTTTTCGGTTCGTATAGTG
CCGGGCCGGAACACGACGTAGGCTACGGCGTAAAAAATAGTCGCTTGTCCTGTAACCCGATGCGCGAGAGTAACCTGCCA
TTTTTACGCTTAATGGGCTTTCGCTCATTTGGCAAAGCGATTGAACGTCGCTACCAGAGTTCTGCGTGGGCGGTAGGGGC
AGGGGTGATCCTGCTGTTTATGCTGGTGCTTGGCTACATCCAGCAATATGGTTATGGCATTGAGTTTATTACCAGTGAGC
AAGCCGTATTATTTGTTCTGCTGGTGGCAGGCTCCGTTGCGCTGGGGGGCATGAGCGACGGGCAGCGTTGGGGAATGATT
TTGTGGTGTTCGGTGACGTTGTCACTGCTCTATTTTATTCTTTATATGTGTTCGTGGAGCACTCTGCTCTGGAAGGGATT
AGCGGGCATTTTGCTGGCCCATTGTGTGTTATTCCTAATCGGTGTAGGACGTAAGTCGTTAAGGAAACGCTATGAACCTG
TTTAA

Upstream 100 bases:

>100_bases
CAATTACGCAGACATTTATTTATCGATTTAGTAGGCGGCGCGTTGCTGGCGTCGATTTGCGGTTGGATATGCGCAACATG
CGAGAAAAGGAAGACGCAAT

Downstream 100 bases:

>100_bases
TCCCGACAGGTTAATCACTTTTCCTGCTGATGATCCGCAACTGGTGAAGCAGCTGCAAAACGATACGAAAGTCTATCTGG
CGAAATCATGCGATCATCGG

Product: hypothetical protein

Products: NA

Alternate protein names: Sterol-C5-desaturase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSDLLFPIISMVLLVLAEAGVLQFTGRQKVDWLDVIFNINSGHMMLWLFRCLEVLCYSLVVNHFSLGLFDNAPGILLWLF
TILAWDFGFYWLHRWHHEMRPLWAVHVVHHQGEHYNLSLGVRNSWYSSLTSIPFFMLLAMLGVPLQVFLAVSIIHYSWQF
FNHNALAPKLGWLEKVLITPSHHRVHHLNEKQYADTNYGGTFLLWDKLFGSYSAGPEHDVGYGVKNSRLSCNPMRESNLP
FLRLMGFRSFGKAIERRYQSSAWAVGAGVILLFMLVLGYIQQYGYGIEFITSEQAVLFVLLVAGSVALGGMSDGQRWGMI
LWCSVTLSLLYFILYMCSWSTLLWKGLAGILLAHCVLFLIGVGRKSLRKRYEPV

Sequences:

>Translated_374_residues
MSDLLFPIISMVLLVLAEAGVLQFTGRQKVDWLDVIFNINSGHMMLWLFRCLEVLCYSLVVNHFSLGLFDNAPGILLWLF
TILAWDFGFYWLHRWHHEMRPLWAVHVVHHQGEHYNLSLGVRNSWYSSLTSIPFFMLLAMLGVPLQVFLAVSIIHYSWQF
FNHNALAPKLGWLEKVLITPSHHRVHHLNEKQYADTNYGGTFLLWDKLFGSYSAGPEHDVGYGVKNSRLSCNPMRESNLP
FLRLMGFRSFGKAIERRYQSSAWAVGAGVILLFMLVLGYIQQYGYGIEFITSEQAVLFVLLVAGSVALGGMSDGQRWGMI
LWCSVTLSLLYFILYMCSWSTLLWKGLAGILLAHCVLFLIGVGRKSLRKRYEPV
>Mature_373_residues
SDLLFPIISMVLLVLAEAGVLQFTGRQKVDWLDVIFNINSGHMMLWLFRCLEVLCYSLVVNHFSLGLFDNAPGILLWLFT
ILAWDFGFYWLHRWHHEMRPLWAVHVVHHQGEHYNLSLGVRNSWYSSLTSIPFFMLLAMLGVPLQVFLAVSIIHYSWQFF
NHNALAPKLGWLEKVLITPSHHRVHHLNEKQYADTNYGGTFLLWDKLFGSYSAGPEHDVGYGVKNSRLSCNPMRESNLPF
LRLMGFRSFGKAIERRYQSSAWAVGAGVILLFMLVLGYIQQYGYGIEFITSEQAVLFVLLVAGSVALGGMSDGQRWGMIL
WCSVTLSLLYFILYMCSWSTLLWKGLAGILLAHCVLFLIGVGRKSLRKRYEPV

Specific function: Unknown

COG id: COG3000

COG function: function code I; Sterol desaturase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sterol desaturase family [H]

Homologues:

Organism=Homo sapiens, GI51972212, Length=231, Percent_Identity=34.1991341991342, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25144659, Length=179, Percent_Identity=30.7262569832402, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006694 [H]

Pfam domain/function: PF04116 FA_hydroxylase [H]

EC number: NA

Molecular weight: Translated: 42833; Mature: 42702

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLLFPIISMVLLVLAEAGVLQFTGRQKVDWLDVIFNINSGHMMLWLFRCLEVLCYSLV
CCCHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
VNHFSLGLFDNAPGILLWLFTILAWDFGFYWLHRWHHEMRPLWAVHVVHHQGEHYNLSLG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEEE
VRNSWYSSLTSIPFFMLLAMLGVPLQVFLAVSIIHYSWQFFNHNALAPKLGWLEKVLITP
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
SHHRVHHLNEKQYADTNYGGTFLLWDKLFGSYSAGPEHDVGYGVKNSRLSCNPMRESNLP
CCHHHHHCCCHHCCCCCCCCEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FLRLMGFRSFGKAIERRYQSSAWAVGAGVILLFMLVLGYIQQYGYGIEFITSEQAVLFVL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
LVAGSVALGGMSDGQRWGMILWCSVTLSLLYFILYMCSWSTLLWKGLAGILLAHCVLFLI
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVGRKSLRKRYEPV
HCCHHHHHHHCCCC
>Mature Secondary Structure 
SDLLFPIISMVLLVLAEAGVLQFTGRQKVDWLDVIFNINSGHMMLWLFRCLEVLCYSLV
CCHHHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
VNHFSLGLFDNAPGILLWLFTILAWDFGFYWLHRWHHEMRPLWAVHVVHHQGEHYNLSLG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCEEEEEEE
VRNSWYSSLTSIPFFMLLAMLGVPLQVFLAVSIIHYSWQFFNHNALAPKLGWLEKVLITP
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
SHHRVHHLNEKQYADTNYGGTFLLWDKLFGSYSAGPEHDVGYGVKNSRLSCNPMRESNLP
CCHHHHHCCCHHCCCCCCCCEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
FLRLMGFRSFGKAIERRYQSSAWAVGAGVILLFMLVLGYIQQYGYGIEFITSEQAVLFVL
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
LVAGSVALGGMSDGQRWGMILWCSVTLSLLYFILYMCSWSTLLWKGLAGILLAHCVLFLI
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVGRKSLRKRYEPV
HCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]