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The map label for this gene is trpD [H]

Identifier: 218549046

GI number: 218549046

Start: 1741233

End: 1742828

Strand: Direct

Name: trpD [H]

Synonym: EFER_1693

Alternate gene names: 218549046

Gene position: 1741233-1742828 (Clockwise)

Preceding gene: 218549045

Following gene: 218549047

Centisome position: 37.95

GC content: 55.08

Gene sequence:

>1596_bases
ATGGCTGACATTCTGCTGCTCGATAATATCGACTCTTTTACTTATAACCTGGCAGATCAGTTGCGCAGCAATGGGCATAA
CGTGGTGATTTACCGCAACCATATTCCGGCGCAAACCTTAATTGAACGTCTTGCGACCATGAGCAATCCGGTGCTGATGC
TTTCTCCTGGCCCCGGAGTGCCGAGTGAAGCGGGTTGTATGCCGGAACTCCTCACCCGTTTGCGTGGCAAGCTGCCAATT
ATTGGCATTTGCCTCGGACATCAGGCGATTGTCGAAGCTTACGGGGGCTATGTCGGTCAGGCGGGCGAAATTCTTCACGG
TAAAGCGTCGAGCATTGAACATGACGGTCAGGCGATGTTTGCCGGATTAACAAATCCATTGCCGGTAGCGCGTTATCACT
CGTTGGTTGGCAGTAACATTCCGGCAGGTTTAACCATCAATGCCCATTTTAACGGCATGGTGATGGCGGTGCGTCATGAT
GCGGATCGTGTTTGCGGATTCCAGTTCCATCCGGAATCCATTCTCACCACCCAGGGGGCTCGCCTGCTGGAACAAACGCT
GGCCTGGGCACAACAGAAACTGGAGCCGACTAATACGCTACAACCAATTCTGGAAAAACTGTATCAGGCGCAGACGCTTA
GCCAACAAGAAAGCCACCAGCTGTTTTCAGCGGTGGTGCGTGGCGAGCTGAAACCGGAACAACTGGCGGCTGCATTGGTC
AGCATGAAAATTCGCGGCGAGCACCCAAACGAAATCGCCGGAGCAGCAACGGCGCTACTGGAAAATGCCGCGCCGTTCCC
ACGCCCTGATTATCTGTTTGCCGATATCGTCGGCACCGGCGGTGACGGCAGCAACAGTATCAATATTTCTACCGCCAGTG
CGTTTGTCGCCGCGGCCTGTGGGCTGAAAGTGGCGAAACACGGTAACCGCAGCGTCTCCAGTAAATCCGGCTCGTCGGAT
CTGCTGGCGGCATTCGGTATTAATCTTGATATGAACGCCGATAAATCGCGCCAGGCGCTGGATGAGTTAGGCGTCTGTTT
CCTCTTTGCGCCGAAATATCACACCGGATTTCGCCATGCGATGCCGGTTCGCCAGCAACTGAAAACCCGCACCCTGTTCA
ACGTGCTGGGGCCACTGATTAACCCGGCGCATCCGCCGCTGGCGCTAATTGGTGTCTACAGCCCGGAACTGGTGCTGCCA
ATTGCCGAAACTTTGCGCGTGCTGGGGTATCAACGCGCAGCGGTGGTGCACAGCGGGGGGATGGATGAAGTTTCATTACA
CGCGCCGACAATCGTTGCCGAACTGCATGACGGCGAAATTAAGAGCTATCAGTTGACCGCTGAAGATTTTGGCCTGACAC
CCTACCATCAGGAGCAACTGGCAGGCGGAACACCGGAAGAAAACCGTGACATTTTAACACGCTTGTTACAAGGTAAAGGC
GACGCCGCCCATGAAGCAGCCGTCGCGGCGAATGTCGCCATGTTAATGCGCCTGCATGGCCATGAAGATCTGCAAGCCAA
TGCGCAAACCGTTCTTGAGGTACTGCGCAGTGGTTCCGCTTACGACAGAGTCACCGCACTGGCGGCACGAGGGTAA

Upstream 100 bases:

>100_bases
TTGATTCTGTTCCGCAGTCGGAAGCCGACGAAACCCGTAATAAAGCCCGCGCTGTACTGCGCGCTATCGCCACCGCGCAT
CATGCACAGGAGACTTTCTG

Downstream 100 bases:

>100_bases
ATGATGCAAACCGTTTTAGCAAAAATCGTCGCAGACAAGGCGATTTGGGTAGAAGCCCGCAAACAGCAGCAACCGCTGGC
CAGTTTTCAGAATAAGGTTC

Product: bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: Glutamine amidotransferase; Anthranilate phosphoribosyltransferase [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MADILLLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPI
IGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHD
ADRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLSQQESHQLFSAVVRGELKPEQLAAALV
SMKIRGEHPNEIAGAATALLENAAPFPRPDYLFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSD
LLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLP
IAETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQEQLAGGTPEENRDILTRLLQGKG
DAAHEAAVAANVAMLMRLHGHEDLQANAQTVLEVLRSGSAYDRVTALAARG

Sequences:

>Translated_531_residues
MADILLLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPI
IGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHD
ADRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLSQQESHQLFSAVVRGELKPEQLAAALV
SMKIRGEHPNEIAGAATALLENAAPFPRPDYLFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSD
LLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLP
IAETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQEQLAGGTPEENRDILTRLLQGKG
DAAHEAAVAANVAMLMRLHGHEDLQANAQTVLEVLRSGSAYDRVTALAARG
>Mature_530_residues
ADILLLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPII
GICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHDA
DRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLSQQESHQLFSAVVRGELKPEQLAAALVS
MKIRGEHPNEIAGAATALLENAAPFPRPDYLFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSDL
LAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPI
AETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQEQLAGGTPEENRDILTRLLQGKGD
AAHEAAVAANVAMLMRLHGHEDLQANAQTVLEVLRSGSAYDRVTALAARG

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787517, Length=531, Percent_Identity=99.8116760828625, Blast_Score=1082, Evalue=0.0,
Organism=Escherichia coli, GI1789760, Length=187, Percent_Identity=43.8502673796791, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322638, Length=227, Percent_Identity=37.0044052863436, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6320561, Length=323, Percent_Identity=33.1269349845201, Blast_Score=130, Evalue=6e-31,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005940
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase; PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3 [H]

EC number: =4.1.3.27; =2.4.2.18 [H]

Molecular weight: Translated: 56901; Mature: 56770

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADILLLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGV
CCCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCC
PSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMF
CCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCEEE
AGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGA
ECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHCCCEECCHHHHHHHHH
RLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLSQQESHQLFSAVVRGELKPEQLAAALV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SMKIRGEHPNEIAGAATALLENAAPFPRPDYLFADIVGTGGDGSNSINISTASAFVAAAC
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEHHHHHHHHHH
GLKVAKHGNRSVSSKSGSSDLLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHA
HHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHH
MPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPIAETLRVLGYQRAAVVHSGG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHEEEECCC
MDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQEQLAGGTPEENRDILTRLLQGKG
CCCEEECCCEEEEEECCCCCCEEEEEHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCC
DAAHEAAVAANVAMLMRLHGHEDLQANAQTVLEVLRSGSAYDRVTALAARG
CHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ADILLLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGV
CCEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCC
PSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMF
CCCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCEEE
AGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGA
ECCCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCHHCCCEECCHHHHHHHHH
RLLEQTLAWAQQKLEPTNTLQPILEKLYQAQTLSQQESHQLFSAVVRGELKPEQLAAALV
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
SMKIRGEHPNEIAGAATALLENAAPFPRPDYLFADIVGTGGDGSNSINISTASAFVAAAC
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEHHHHHHHHHH
GLKVAKHGNRSVSSKSGSSDLLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHA
HHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCEEEEECCCCCCCCHHH
MPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPIAETLRVLGYQRAAVVHSGG
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCHHHEEEECCC
MDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQEQLAGGTPEENRDILTRLLQGKG
CCCEEECCCEEEEEECCCCCCEEEEEHHHCCCCCCCHHHHCCCCCCCHHHHHHHHHHCCC
DAAHEAAVAANVAMLMRLHGHEDLQANAQTVLEVLRSGSAYDRVTALAARG
CHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7038627; 6283099; 9097039; 9278503; 4594441 [H]