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The map label for this gene is trpE [H]

Identifier: 218549045

GI number: 218549045

Start: 1739671

End: 1741233

Strand: Direct

Name: trpE [H]

Synonym: EFER_1692

Alternate gene names: 218549045

Gene position: 1739671-1741233 (Clockwise)

Preceding gene: 218549044

Following gene: 218549046

Centisome position: 37.91

GC content: 53.93

Gene sequence:

>1563_bases
ATGCAAACACAAAAACCGACTCTCGAACTGTTAACCTGCGAAGGTGCTTATCGCGATAATCCGACCGCGCTTTTTCACCA
GTTGTGTGGGGATCGTCCGGCAACGCTGCTGCTGGAATCCGCAGATATCGACAGCAAAGATGATTTAAAAAGTCTATTGC
TAGTGGACAGTGCGCTGCGCATTACGGCATTAGGTGACACTGTCACAATTAAGGCGCTCTCCGGCAATGGCGAAGCCCTG
TTGACACTACTGGATAACGCCCTGCCCGCTGGGGTCGATAATGAGCAATCGCCACAATGCCGCGTACTGCGCTTCCCCCC
GGTCAGTCCACTGTTGGATGAAGACGCCCGCTTATGCTCCCTTTCGGTTTTTGACGCTTTCCGCTTATTACAGAATCTGT
TGAATGTACCGAAGGAAGAACGGGAAGCGATGTTCTTTGGCGGCCTGTTCTCTTATGACCTTGTGGCGGGATTTGAAGAT
TTACCGCAACTGGCAGCGGAAAATAACTGCCCTGATTTCTGTTTTTATCTCGCTGAAACGCTGATGGTTATCGATCATCA
GAAAAAAAGTACCCGTATTCAGGCCAGCCTGTTTGGTCAAAATGAAGAAGAAAAACAACGTCTCACTGCTCGCCTGAACG
AACTTCGCCAGCAACTGACCGAAACCGCGCCACCGCTGCCGGTAGTTTCCGTGCCGCATATGCATTGTGAATGTAATCAG
AGCGATGAAGAGTTCGGTGGCGTAGTGCGTTCGTTGCAAAAAGCGATTCGCGCCGGAGAAATTTTCCAGGTCGTACCATC
TCGCCGTTTCTCACTGCCCTGCCCGTCATCGCTGGCGGCCTATTACGTGCTGAAAAAGAGTAATCCCAGCCCGTACATGT
TTTTTATGCAGGATAATGATTTCACCCTGTTCGGCGCGTCACCGGAAAGTTCGCTCAAGTTTGACGCCTCCAGCCGCCAG
ATTGAGATCTACCCGATTGCCGGAACACGCCCACGAGGACGTCGCGCCGATGGTTCACTGGACAAAGACCTCGACAGCCG
CATTGAACTGGAGATGCGTACCGACCATAAAGAGCTTTCTGAACATCTGATGCTGGTGGATCTCGCCCGTAATGATCTGG
CACGCATTTGCACTCCTGGCAGCCGCTACGTAGCCGATCTCACCAAAGTTGACCGTTACTCTTACGTGATGCATCTCGTC
TCCCGCGTGGTCGGTGAGCTGCGCCACGATCTTGACGCCCTGCACGCTTACCGCGCCTGTATGAACATGGGTACGTTAAG
CGGTGCCCCGAAAGTGCGCGCCATGCAGTTAATTGCCGAGGCTGAAGGTCGCCGCCGCGGCAGCTATGGCGGTGCAGTAG
GTTATTTCACCGCGCACGGCGATCTCGACACCTGCATTGTCATCCGTTCGGCGCTGGTGGAAAACGGTATCGCCACCGTG
CAAGCCGGTGCTGGCGTAGTCCTTGATTCTGTTCCGCAGTCGGAAGCCGACGAAACCCGTAATAAAGCCCGCGCTGTACT
GCGCGCTATCGCCACCGCGCATCATGCACAGGAGACTTTCTGA

Upstream 100 bases:

>100_bases
ACTTCCTGAAACGGGCAGTGTATTCACCATGCGTAAAGCAACCAGATACCCAGCCCGCCTAATGAGCGGGCTTTTTTTTG
AACAAAATTAGAGAATAACA

Downstream 100 bases:

>100_bases
TGGCTGACATTCTGCTGCTCGATAATATCGACTCTTTTACTTATAACCTGGCAGATCAGTTGCGCAGCAATGGGCATAAC
GTGGTGATTTACCGCAACCA

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIKALSGNGEAL
LTLLDNALPAGVDNEQSPQCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFED
LPQLAAENNCPDFCFYLAETLMVIDHQKKSTRIQASLFGQNEEEKQRLTARLNELRQQLTETAPPLPVVSVPHMHCECNQ
SDEEFGGVVRSLQKAIRAGEIFQVVPSRRFSLPCPSSLAAYYVLKKSNPSPYMFFMQDNDFTLFGASPESSLKFDASSRQ
IEIYPIAGTRPRGRRADGSLDKDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLV
SRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
QAGAGVVLDSVPQSEADETRNKARAVLRAIATAHHAQETF

Sequences:

>Translated_520_residues
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIKALSGNGEAL
LTLLDNALPAGVDNEQSPQCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFED
LPQLAAENNCPDFCFYLAETLMVIDHQKKSTRIQASLFGQNEEEKQRLTARLNELRQQLTETAPPLPVVSVPHMHCECNQ
SDEEFGGVVRSLQKAIRAGEIFQVVPSRRFSLPCPSSLAAYYVLKKSNPSPYMFFMQDNDFTLFGASPESSLKFDASSRQ
IEIYPIAGTRPRGRRADGSLDKDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLV
SRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
QAGAGVVLDSVPQSEADETRNKARAVLRAIATAHHAQETF
>Mature_520_residues
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALRITALGDTVTIKALSGNGEAL
LTLLDNALPAGVDNEQSPQCRVLRFPPVSPLLDEDARLCSLSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFED
LPQLAAENNCPDFCFYLAETLMVIDHQKKSTRIQASLFGQNEEEKQRLTARLNELRQQLTETAPPLPVVSVPHMHCECNQ
SDEEFGGVVRSLQKAIRAGEIFQVVPSRRFSLPCPSSLAAYYVLKKSNPSPYMFFMQDNDFTLFGASPESSLKFDASSRQ
IEIYPIAGTRPRGRRADGSLDKDLDSRIELEMRTDHKELSEHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLV
SRVVGELRHDLDALHAYRACMNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
QAGAGVVLDSVPQSEADETRNKARAVLRAIATAHHAQETF

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=520, Percent_Identity=97.1153846153846, Blast_Score=1013, Evalue=0.0,
Organism=Escherichia coli, GI1788114, Length=422, Percent_Identity=30.0947867298578, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786809, Length=254, Percent_Identity=27.1653543307087, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=399, Percent_Identity=36.5914786967419, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324361, Length=256, Percent_Identity=28.90625, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 57470; Mature: 57470

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALR
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCEE
ITALGDTVTIKALSGNGEALLTLLDNALPAGVDNEQSPQCRVLRFPPVSPLLDEDARLCS
EEEECCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
LSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFEDLPQLAAENNCPDFCFYLAET
HHHHHHHHHHHHHHCCCHHHHHHEEECCHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHH
LMVIDHQKKSTRIQASLFGQNEEEKQRLTARLNELRQQLTETAPPLPVVSVPHMHCECNQ
HHHHCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCC
SDEEFGGVVRSLQKAIRAGEIFQVVPSRRFSLPCPSSLAAYYVLKKSNPSPYMFFMQDND
CHHHHHHHHHHHHHHHHHCHHEEECCCCCCCCCCCCHHEEEEEEECCCCCCEEEEEECCC
FTLFGASPESSLKFDASSRQIEIYPIAGTRPRGRRADGSLDKDLDSRIELEMRTDHKELS
EEEEECCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHH
EHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRAC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
HHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEE
QAGAGVVLDSVPQSEADETRNKARAVLRAIATAHHAQETF
ECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTQKPTLELLTCEGAYRDNPTALFHQLCGDRPATLLLESADIDSKDDLKSLLLVDSALR
CCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCEE
ITALGDTVTIKALSGNGEALLTLLDNALPAGVDNEQSPQCRVLRFPPVSPLLDEDARLCS
EEEECCEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHH
LSVFDAFRLLQNLLNVPKEEREAMFFGGLFSYDLVAGFEDLPQLAAENNCPDFCFYLAET
HHHHHHHHHHHHHHCCCHHHHHHEEECCHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHH
LMVIDHQKKSTRIQASLFGQNEEEKQRLTARLNELRQQLTETAPPLPVVSVPHMHCECNQ
HHHHCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCC
SDEEFGGVVRSLQKAIRAGEIFQVVPSRRFSLPCPSSLAAYYVLKKSNPSPYMFFMQDND
CHHHHHHHHHHHHHHHHHCHHEEECCCCCCCCCCCCHHEEEEEEECCCCCCEEEEEECCC
FTLFGASPESSLKFDASSRQIEIYPIAGTRPRGRRADGSLDKDLDSRIELEMRTDHKELS
EEEEECCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHH
EHLMLVDLARNDLARICTPGSRYVADLTKVDRYSYVMHLVSRVVGELRHDLDALHAYRAC
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNMGTLSGAPKVRAMQLIAEAEGRRRGSYGGAVGYFTAHGDLDTCIVIRSALVENGIATV
HHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEE
QAGAGVVLDSVPQSEADETRNKARAVLRAIATAHHAQETF
ECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7038627; 7021857; 9097039; 9278503; 351195; 4598537 [H]