Click here to switch to the map view.

The map label for this gene is gmr [H]

Identifier: 218549020

GI number: 218549020

Start: 1715621

End: 1717612

Strand: Direct

Name: gmr [H]

Synonym: EFER_1668

Alternate gene names: 218549020

Gene position: 1715621-1717612 (Clockwise)

Preceding gene: 218549019

Following gene: 218549021

Centisome position: 37.39

GC content: 46.34

Gene sequence:

>1992_bases
ATGAAAATCGTTATGGAGCCTGCCACGTTGTATAACTATTTGGGTACTCACACTCCTTTCTGGCGTTTGTCAGATAACTG
TAATGTTCTGCATCTTTCGACGATTGAAGCAGCAGAATCTGAACGCACCATTGAGTTATCTCCTGAACAAGCTAACCGTA
TTCGTGAAATGACGGTTATTACTTCCAGTATGATGATGACGCTACCGCTGGAAGAAAGTGATGTTTCAGTTCATCTGGTT
GGACGCAAAATCAATAAGCGTGAATGGGCAGGCAGCGCATCCGCATGGCATGATACCCCTTCTGTTGCTCGTGACTTAAT
GCACGGGCTTTCTTTTGCTGAACAGGTTGTCTCCGAAGCGAACTCAGCCATTTTGATCCTCGACAGCCGGGGCAACATTC
AACGATTTAATCGCTTATGCGAAGAATATACCGGTTTAAAAGAACATGAAGTCATTGGTCAAAGCGTATTCAAACTCTTT
ATGAGTCGTCGGGAAGCTGCAGCCTCCCGACGTAACATTGACGTTTTTTTCCGTAGTGGAAACGCATGGGAAGTTGAACG
CTGGATCAAAACCCGTAAAGGACAACGCCTGTTCCTTTTTCGCAATAAATTCATTCATAGCGGCAGTGGTAAAAATGAAA
TTTATTTAATCTGTTCGGGGACTGATATCACTGAGGAGCGTGTGGCCCAGGAACGTCTGCGGGTACTCGCCAATACAGAT
ACGATTACCGGGCTTCCTAATCGTAACGCTATTCATGAGTTGATCGATAATGCTATCGTTCAGACTACAAACGCTCAGGT
CGGCATTGTTTATCTCGATCTCGATAATTTCAAAAAAGTGAACGATGCTTACGGCCATATGTTTGGTGACCAACTGCTGC
AAGCCGTTGCATTGGCCATACTCAGTTGTCTCGATAACGATCAGACGCTGGCACGTCATGGTGGTGATGAGTTTATCGTC
CTGGCACCAGACACTTCACAAGGTGCGCTTGAAGCCATGGCATCTCGTATTCTTACGCGCCTGCGCTTACCTTTTCGTAT
TGGTTTGATTGAAGTACAGACCGGCTGCTCGGTTGGCATTGCACTTTCACCTTTGCATGGTCATGACAGCGACAGTCTTA
TCCGGAGCGCCGATACGGCCATGTACACCGCTAAAGAAGGCGGTCGAGGTCAATTCTGTGTCTTTTCTCCCGAAATGAAT
CAGCGTGTTTTTGAGTATTTGTGGCTGGACACTAACTTACGTAAAGCTCTGGAGAATGATCAACTGCTGATTCACTATCA
ACCAAAGGTCACTTGGCGCGGAGAAGTGCGCAGTCTCGAAGCGCTGGTACGATGGCAGTCGCCTGAGCGTGGACTCATTC
CTCCGGGTGAATTTATCTCTTATGCAGAAGAATCAGGATTAATTGTTCCGCTTGGTCGCTGGGTCATTCTTGATGTAGTG
CGCCAGGTGGCAAAATGGCGAAGCAAAGGAATTAATTTACGTGTAGCGGTCAACATTTCTGCTCGCCAACTGGCAGACCA
AACTATTTTTACCTATCTGAAACAAGTTTTGCATGAGCTTGATTTTGAATACTGCCCTATCGACGTAGAATTAACCGAAC
GCTGTCTGCTCGAAAATGAAGCACTGGCGTTGTCTGTCATTCAGCAATTTAGCCGCCTCGGGGCGCAGGTGCACCTGGAT
GATTTTGGTACGGGATATTCATCACTGTCACAACTGGCACGTTTTCCTATAGATGCCATAAAACTCGATCAGGCCTTTGT
TCGCAATATACACAAGCAATCTGTTTCTCAGTCGTTAGTGAGGGCGATTGTGGCGGTTGCTCAGGCACTTAACCTGCAAG
TCATTGCCGAAGGTGTTGAAAGCGTGAAAGAGGATGCTTTCCTGACGAAAAATGGCGTTAACGAACGACAAGGTTTTTTG
TTTGCCAAACCCATGCCTGCTGTAGCCTTTGAGCGTTGGTATAAGCGTTATTTAAATAAAACAATGCGTTGA

Upstream 100 bases:

>100_bases
AACTAATTGTATAAATAAAACAATACGTTCTCTTTACATCACCTAATCTTAATCATCGCTGATAGCTGCGGTATGTGCTT
GCAACAAGATGGTGTAGATC

Downstream 100 bases:

>100_bases
ACTCGCTGGAGATGATTAACTACATGCAAAGAAAATGATGACGCAATACATAATTTTGCCAATTAACTATTATCCGGGCA
ATTTTCCACTTCTCTTTTAG

Product: RNase II stability modulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MKIVMEPATLYNYLGTHTPFWRLSDNCNVLHLSTIEAAESERTIELSPEQANRIREMTVITSSMMMTLPLEESDVSVHLV
GRKINKREWAGSASAWHDTPSVARDLMHGLSFAEQVVSEANSAILILDSRGNIQRFNRLCEEYTGLKEHEVIGQSVFKLF
MSRREAAASRRNIDVFFRSGNAWEVERWIKTRKGQRLFLFRNKFIHSGSGKNEIYLICSGTDITEERVAQERLRVLANTD
TITGLPNRNAIHELIDNAIVQTTNAQVGIVYLDLDNFKKVNDAYGHMFGDQLLQAVALAILSCLDNDQTLARHGGDEFIV
LAPDTSQGALEAMASRILTRLRLPFRIGLIEVQTGCSVGIALSPLHGHDSDSLIRSADTAMYTAKEGGRGQFCVFSPEMN
QRVFEYLWLDTNLRKALENDQLLIHYQPKVTWRGEVRSLEALVRWQSPERGLIPPGEFISYAEESGLIVPLGRWVILDVV
RQVAKWRSKGINLRVAVNISARQLADQTIFTYLKQVLHELDFEYCPIDVELTERCLLENEALALSVIQQFSRLGAQVHLD
DFGTGYSSLSQLARFPIDAIKLDQAFVRNIHKQSVSQSLVRAIVAVAQALNLQVIAEGVESVKEDAFLTKNGVNERQGFL
FAKPMPAVAFERWYKRYLNKTMR

Sequences:

>Translated_663_residues
MKIVMEPATLYNYLGTHTPFWRLSDNCNVLHLSTIEAAESERTIELSPEQANRIREMTVITSSMMMTLPLEESDVSVHLV
GRKINKREWAGSASAWHDTPSVARDLMHGLSFAEQVVSEANSAILILDSRGNIQRFNRLCEEYTGLKEHEVIGQSVFKLF
MSRREAAASRRNIDVFFRSGNAWEVERWIKTRKGQRLFLFRNKFIHSGSGKNEIYLICSGTDITEERVAQERLRVLANTD
TITGLPNRNAIHELIDNAIVQTTNAQVGIVYLDLDNFKKVNDAYGHMFGDQLLQAVALAILSCLDNDQTLARHGGDEFIV
LAPDTSQGALEAMASRILTRLRLPFRIGLIEVQTGCSVGIALSPLHGHDSDSLIRSADTAMYTAKEGGRGQFCVFSPEMN
QRVFEYLWLDTNLRKALENDQLLIHYQPKVTWRGEVRSLEALVRWQSPERGLIPPGEFISYAEESGLIVPLGRWVILDVV
RQVAKWRSKGINLRVAVNISARQLADQTIFTYLKQVLHELDFEYCPIDVELTERCLLENEALALSVIQQFSRLGAQVHLD
DFGTGYSSLSQLARFPIDAIKLDQAFVRNIHKQSVSQSLVRAIVAVAQALNLQVIAEGVESVKEDAFLTKNGVNERQGFL
FAKPMPAVAFERWYKRYLNKTMR
>Mature_663_residues
MKIVMEPATLYNYLGTHTPFWRLSDNCNVLHLSTIEAAESERTIELSPEQANRIREMTVITSSMMMTLPLEESDVSVHLV
GRKINKREWAGSASAWHDTPSVARDLMHGLSFAEQVVSEANSAILILDSRGNIQRFNRLCEEYTGLKEHEVIGQSVFKLF
MSRREAAASRRNIDVFFRSGNAWEVERWIKTRKGQRLFLFRNKFIHSGSGKNEIYLICSGTDITEERVAQERLRVLANTD
TITGLPNRNAIHELIDNAIVQTTNAQVGIVYLDLDNFKKVNDAYGHMFGDQLLQAVALAILSCLDNDQTLARHGGDEFIV
LAPDTSQGALEAMASRILTRLRLPFRIGLIEVQTGCSVGIALSPLHGHDSDSLIRSADTAMYTAKEGGRGQFCVFSPEMN
QRVFEYLWLDTNLRKALENDQLLIHYQPKVTWRGEVRSLEALVRWQSPERGLIPPGEFISYAEESGLIVPLGRWVILDVV
RQVAKWRSKGINLRVAVNISARQLADQTIFTYLKQVLHELDFEYCPIDVELTERCLLENEALALSVIQQFSRLGAQVHLD
DFGTGYSSLSQLARFPIDAIKLDQAFVRNIHKQSVSQSLVRAIVAVAQALNLQVIAEGVESVKEDAFLTKNGVNERQGFL
FAKPMPAVAFERWYKRYLNKTMR

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=660, Percent_Identity=84.8484848484848, Blast_Score=1169, Evalue=0.0,
Organism=Escherichia coli, GI87081921, Length=439, Percent_Identity=33.7129840546697, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI226510982, Length=425, Percent_Identity=31.5294117647059, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1788502, Length=243, Percent_Identity=31.6872427983539, Blast_Score=146, Evalue=4e-36,
Organism=Escherichia coli, GI87081743, Length=247, Percent_Identity=31.9838056680162, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1790496, Length=249, Percent_Identity=32.5301204819277, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87081845, Length=238, Percent_Identity=34.453781512605, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1787055, Length=294, Percent_Identity=30.952380952381, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788849, Length=430, Percent_Identity=26.046511627907, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1786507, Length=256, Percent_Identity=30.078125, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI87081980, Length=258, Percent_Identity=31.3953488372093, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1788381, Length=551, Percent_Identity=25.2268602540835, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082096, Length=426, Percent_Identity=25.5868544600939, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI87081977, Length=177, Percent_Identity=32.2033898305085, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI87081881, Length=200, Percent_Identity=30, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787816, Length=173, Percent_Identity=32.3699421965318, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1787262, Length=165, Percent_Identity=33.9393939393939, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786584, Length=168, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI145693134, Length=155, Percent_Identity=30.3225806451613, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI87082007, Length=171, Percent_Identity=34.5029239766082, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789650, Length=435, Percent_Identity=22.0689655172414, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1787410, Length=127, Percent_Identity=33.8582677165354, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1787802, Length=158, Percent_Identity=30.379746835443, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788956, Length=153, Percent_Identity=32.6797385620915, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 74928; Mature: 74928

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS50112 PAS ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVMEPATLYNYLGTHTPFWRLSDNCNVLHLSTIEAAESERTIELSPEQANRIREMTVI
CEEEECHHHHHHHHCCCCCCEEECCCCCEEEEEEHHHCCCCCEEEECHHHHHHHHHHHHH
TSSMMMTLPLEESDVSVHLVGRKINKREWAGSASAWHDTPSVARDLMHGLSFAEQVVSEA
HHHEEEEECCCCCCCEEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
NSAILILDSRGNIQRFNRLCEEYTGLKEHEVIGQSVFKLFMSRREAAASRRNIDVFFRSG
CCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
NAWEVERWIKTRKGQRLFLFRNKFIHSGSGKNEIYLICSGTDITEERVAQERLRVLANTD
CCCHHHHHHHHCCCCEEEEEEHHHEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC
TITGLPNRNAIHELIDNAIVQTTNAQVGIVYLDLDNFKKVNDAYGHMFGDQLLQAVALAI
CCCCCCCCHHHHHHHHHHHEEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LSCLDNDQTLARHGGDEFIVLAPDTSQGALEAMASRILTRLRLPFRIGLIEVQTGCSVGI
HHHCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCE
ALSPLHGHDSDSLIRSADTAMYTAKEGGRGQFCVFSPEMNQRVFEYLWLDTNLRKALEND
EEECCCCCCCHHHHHHCCHHEEEECCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHCCCC
QLLIHYQPKVTWRGEVRSLEALVRWQSPERGLIPPGEFISYAEESGLIVPLGRWVILDVV
CEEEEECCCEEECHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECHHHHHHHHH
RQVAKWRSKGINLRVAVNISARQLADQTIFTYLKQVLHELDFEYCPIDVELTERCLLENE
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
ALALSVIQQFSRLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQAFVRNIHKQSVSQSLV
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
RAIVAVAQALNLQVIAEGVESVKEDAFLTKNGVNERQGFLFAKPMPAVAFERWYKRYLNK
HHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
TMR
HCC
>Mature Secondary Structure
MKIVMEPATLYNYLGTHTPFWRLSDNCNVLHLSTIEAAESERTIELSPEQANRIREMTVI
CEEEECHHHHHHHHCCCCCCEEECCCCCEEEEEEHHHCCCCCEEEECHHHHHHHHHHHHH
TSSMMMTLPLEESDVSVHLVGRKINKREWAGSASAWHDTPSVARDLMHGLSFAEQVVSEA
HHHEEEEECCCCCCCEEEEECCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
NSAILILDSRGNIQRFNRLCEEYTGLKEHEVIGQSVFKLFMSRREAAASRRNIDVFFRSG
CCEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
NAWEVERWIKTRKGQRLFLFRNKFIHSGSGKNEIYLICSGTDITEERVAQERLRVLANTD
CCCHHHHHHHHCCCCEEEEEEHHHEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCC
TITGLPNRNAIHELIDNAIVQTTNAQVGIVYLDLDNFKKVNDAYGHMFGDQLLQAVALAI
CCCCCCCCHHHHHHHHHHHEEECCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LSCLDNDQTLARHGGDEFIVLAPDTSQGALEAMASRILTRLRLPFRIGLIEVQTGCSVGI
HHHCCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCE
ALSPLHGHDSDSLIRSADTAMYTAKEGGRGQFCVFSPEMNQRVFEYLWLDTNLRKALEND
EEECCCCCCCHHHHHHCCHHEEEECCCCCCCEEEECCCHHHHHHHHHHCCHHHHHHCCCC
QLLIHYQPKVTWRGEVRSLEALVRWQSPERGLIPPGEFISYAEESGLIVPLGRWVILDVV
CEEEEECCCEEECHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEECHHHHHHHHH
RQVAKWRSKGINLRVAVNISARQLADQTIFTYLKQVLHELDFEYCPIDVELTERCLLENE
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
ALALSVIQQFSRLGAQVHLDDFGTGYSSLSQLARFPIDAIKLDQAFVRNIHKQSVSQSLV
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
RAIVAVAQALNLQVIAEGVESVKEDAFLTKNGVNERQGFLFAKPMPAVAFERWYKRYLNK
HHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHH
TMR
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]