Click here to switch to the map view.

The map label for this gene is tyrR [H]

Identifier: 218549003

GI number: 218549003

Start: 1698371

End: 1699912

Strand: Reverse

Name: tyrR [H]

Synonym: EFER_1651

Alternate gene names: 218549003

Gene position: 1699912-1698371 (Counterclockwise)

Preceding gene: 218549004

Following gene: 218549001

Centisome position: 37.05

GC content: 50.19

Gene sequence:

>1542_bases
ATGCGTCTGGAAGTCTTTTGTGAAGACCGGCTCGGTCTGACCCGCGAACTGCTCGATATTCTTGTGCTACGTGGCATTGA
TTTACGCGGTATTGAGATCGATCCCATCGGGCGAATTTACCTTAACTTCGCTGAACTGGAGTTCAATACATTCAGTAGCC
TGATGGCTGAAATTCGCCGTATCTCCGGCGTTACAGATGTTCGCACTGTTCCCTGGATGCCTTCTGAGCGTGAGCATCTG
GCGCTCAGCGCATTACTTGAAGCTCTTCCGGAACCTGTTTTATCGCTGGATATGAAAAGTAAGGTTGAGATTGCTAACCC
GGCAAGTTGTCAACTTTTTGGTCAACATCTCGATCGCCTGCGTAACCATACCGCCGCGCAATTGATTAATGGTTTTAATT
TTCTGCGCTGGCTGGAAGGTAATCCGCAAACATCACATAACGAACATGTGGTGATTAACGGGCAAAACTTCCTGATGGAA
ATCACGCCTGTGTATTTGCAGGATGAAAACGATCAGCACGTGCTGACAGGCGCGGTGGTGATGTTGCGTTCTACCATTCG
GATGGGGCGTCAGCTGCAAAACATCACCTCTCAAGATGTTAGCGCTTTCAGTCAGATTGTCGCCGTTAGCCCGAAAATGA
AACATGTAGTTGAGCAGGCGCGCAAACTGGCGATGCTGAGTGCGCCACTGTTGATTACCGGTGATACCGGCACAGGTAAA
GATCTCTTTGCTCACGCGTGCCACCAGGCCAGTCCACGAGCGGGGAAACCTTATCTGGCGCTTAATTGTGCTTCTATCCC
GGAAGACGCCGTTGAAAGTGAACTGTTTGGTCACGCACCGGAAGGCAAAAAAGGCTTCTTCGAGCAGGCGAATGGTGGCT
CTGTTCTGCTGGATGAAATTGGCGAGATGTCACCACGTATGCAGACCAAACTACTGCGTTTTCTTAACGACGGTACTTTC
CGCCGTGTTGGTGAGGACCACGAAGTTCATGTGGATGTACGGGTGATTTGCGCGACGCAGAAAAACCTGGTTGAGTTGGT
ACAAAAAGGCCTGTTCCGGGAAGATCTCTATTATCGCCTTAACGTTTTGACACTAAATCTGCCGCCACTACGCGATTGCC
CGCAAGATATTATGCCTTTGACGGAGTTGTTCGTGGCCCGTTTTGCTGATGAGCAAGGCGTGCCGAGACCAAAACTGGCC
GCCGATCTCAATACCGTACTGACCCGTTATGCCTGGCCTGGAAACGTGCGTCAGTTAAAAAATGCGATCTATCGAGCATT
AACGCAACTGGATGGTTATGAGCTGCGCTCGCAGGATATTCTGTTACCAGACTATGATGTCGCCACGGTGGCTGTCGGTG
AAGATGCGATGGAAGGTTCGCTGGATGAGATCACCAGCCGCTTTGAACGTTCGGTGCTGACACAACTGTATCGTAATTAT
CCCAGCACACGTAAGCTGGCAAAACGGCTGGGGGTTTCGCACACCGCCATCGCCAATAAATTGCGTGAATATGGTCTGAA
TCAGAAAAAAAGCGAAGAGTAA

Upstream 100 bases:

>100_bases
TTCCGTCATTCTGTCAATATTTGTTGACAGAGTTCTTCCTGCTTCCCTCAGAGTGGCTTATCATCTTATCTAATGATTCA
TTATTCAGGTGAAGGTTCCC

Downstream 100 bases:

>100_bases
TGTTAAAGCCTGATAGCAGGATAGCAGAGTTGCTTATCAGGCTTTTCGCTTCTTACGCTTTCAGCACAGTGAGTGCGGTG
TCGTAATCCGGTTCGGTGGT

Product: DNA-binding transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MRLEVFCEDRLGLTRELLDILVLRGIDLRGIEIDPIGRIYLNFAELEFNTFSSLMAEIRRISGVTDVRTVPWMPSEREHL
ALSALLEALPEPVLSLDMKSKVEIANPASCQLFGQHLDRLRNHTAAQLINGFNFLRWLEGNPQTSHNEHVVINGQNFLME
ITPVYLQDENDQHVLTGAVVMLRSTIRMGRQLQNITSQDVSAFSQIVAVSPKMKHVVEQARKLAMLSAPLLITGDTGTGK
DLFAHACHQASPRAGKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEIGEMSPRMQTKLLRFLNDGTF
RRVGEDHEVHVDVRVICATQKNLVELVQKGLFREDLYYRLNVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLA
ADLNTVLTRYAWPGNVRQLKNAIYRALTQLDGYELRSQDILLPDYDVATVAVGEDAMEGSLDEITSRFERSVLTQLYRNY
PSTRKLAKRLGVSHTAIANKLREYGLNQKKSEE

Sequences:

>Translated_513_residues
MRLEVFCEDRLGLTRELLDILVLRGIDLRGIEIDPIGRIYLNFAELEFNTFSSLMAEIRRISGVTDVRTVPWMPSEREHL
ALSALLEALPEPVLSLDMKSKVEIANPASCQLFGQHLDRLRNHTAAQLINGFNFLRWLEGNPQTSHNEHVVINGQNFLME
ITPVYLQDENDQHVLTGAVVMLRSTIRMGRQLQNITSQDVSAFSQIVAVSPKMKHVVEQARKLAMLSAPLLITGDTGTGK
DLFAHACHQASPRAGKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEIGEMSPRMQTKLLRFLNDGTF
RRVGEDHEVHVDVRVICATQKNLVELVQKGLFREDLYYRLNVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLA
ADLNTVLTRYAWPGNVRQLKNAIYRALTQLDGYELRSQDILLPDYDVATVAVGEDAMEGSLDEITSRFERSVLTQLYRNY
PSTRKLAKRLGVSHTAIANKLREYGLNQKKSEE
>Mature_513_residues
MRLEVFCEDRLGLTRELLDILVLRGIDLRGIEIDPIGRIYLNFAELEFNTFSSLMAEIRRISGVTDVRTVPWMPSEREHL
ALSALLEALPEPVLSLDMKSKVEIANPASCQLFGQHLDRLRNHTAAQLINGFNFLRWLEGNPQTSHNEHVVINGQNFLME
ITPVYLQDENDQHVLTGAVVMLRSTIRMGRQLQNITSQDVSAFSQIVAVSPKMKHVVEQARKLAMLSAPLLITGDTGTGK
DLFAHACHQASPRAGKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEIGEMSPRMQTKLLRFLNDGTF
RRVGEDHEVHVDVRVICATQKNLVELVQKGLFREDLYYRLNVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLA
ADLNTVLTRYAWPGNVRQLKNAIYRALTQLDGYELRSQDILLPDYDVATVAVGEDAMEGSLDEITSRFERSVLTQLYRNY
PSTRKLAKRLGVSHTAIANKLREYGLNQKKSEE

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=513, Percent_Identity=95.7115009746589, Blast_Score=1001, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=319, Percent_Identity=39.4984326018809, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1790299, Length=331, Percent_Identity=40.785498489426, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI87082152, Length=338, Percent_Identity=37.8698224852071, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1790437, Length=304, Percent_Identity=37.171052631579, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1788905, Length=285, Percent_Identity=39.6491228070175, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789087, Length=333, Percent_Identity=36.036036036036, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789233, Length=349, Percent_Identity=32.378223495702, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87082117, Length=329, Percent_Identity=35.8662613981763, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786524, Length=237, Percent_Identity=45.1476793248945, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI87081872, Length=220, Percent_Identity=40.4545454545455, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789828, Length=244, Percent_Identity=35.655737704918, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI87081858, Length=444, Percent_Identity=24.7747747747748, Blast_Score=118, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57724; Mature: 57724

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVFCEDRLGLTRELLDILVLRGIDLRGIEIDPIGRIYLNFAELEFNTFSSLMAEIRR
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
ISGVTDVRTVPWMPSEREHLALSALLEALPEPVLSLDMKSKVEIANPASCQLFGQHLDRL
HCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
RNHTAAQLINGFNFLRWLEGNPQTSHNEHVVINGQNFLMEITPVYLQDENDQHVLTGAVV
HHHHHHHHHHHHHHHHEECCCCCCCCCCEEEECCCCEEEEEEEEEEECCCCCCHHHHHHH
MLRSTIRMGRQLQNITSQDVSAFSQIVAVSPKMKHVVEQARKLAMLSAPLLITGDTGTGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCH
DLFAHACHQASPRAGKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEI
HHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHH
GEMSPRMQTKLLRFLNDGTFRRVGEDHEVHVDVRVICATQKNLVELVQKGLFREDLYYRL
HCCCHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEECCHHHHHHHHHHCCHHHHHEEEE
NVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLAADLNTVLTRYAWPGNVRQLK
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
NAIYRALTQLDGYELRSQDILLPDYDVATVAVGEDAMEGSLDEITSRFERSVLTQLYRNY
HHHHHHHHHCCCCEECCCCEECCCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHCC
PSTRKLAKRLGVSHTAIANKLREYGLNQKKSEE
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRLEVFCEDRLGLTRELLDILVLRGIDLRGIEIDPIGRIYLNFAELEFNTFSSLMAEIRR
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
ISGVTDVRTVPWMPSEREHLALSALLEALPEPVLSLDMKSKVEIANPASCQLFGQHLDRL
HCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
RNHTAAQLINGFNFLRWLEGNPQTSHNEHVVINGQNFLMEITPVYLQDENDQHVLTGAVV
HHHHHHHHHHHHHHHHEECCCCCCCCCCEEEECCCCEEEEEEEEEEECCCCCCHHHHHHH
MLRSTIRMGRQLQNITSQDVSAFSQIVAVSPKMKHVVEQARKLAMLSAPLLITGDTGTGK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCH
DLFAHACHQASPRAGKPYLALNCASIPEDAVESELFGHAPEGKKGFFEQANGGSVLLDEI
HHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHH
GEMSPRMQTKLLRFLNDGTFRRVGEDHEVHVDVRVICATQKNLVELVQKGLFREDLYYRL
HCCCHHHHHHHHHHHCCCCHHHCCCCCEEEEEEEEEECCHHHHHHHHHHCCHHHHHEEEE
NVLTLNLPPLRDCPQDIMPLTELFVARFADEQGVPRPKLAADLNTVLTRYAWPGNVRQLK
EEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
NAIYRALTQLDGYELRSQDILLPDYDVATVAVGEDAMEGSLDEITSRFERSVLTQLYRNY
HHHHHHHHHCCCCEECCCCEECCCCCEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHCC
PSTRKLAKRLGVSHTAIANKLREYGLNQKKSEE
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA