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The map label for this gene is adhP [H]

Identifier: 218548850

GI number: 218548850

Start: 1530695

End: 1531705

Strand: Reverse

Name: adhP [H]

Synonym: EFER_1495

Alternate gene names: 218548850

Gene position: 1531705-1530695 (Counterclockwise)

Preceding gene: 218548851

Following gene: 218548849

Centisome position: 33.38

GC content: 53.51

Gene sequence:

>1011_bases
ATGAAGGCTGCAGTTGTTACGAAGGATCATCATGTTGACGTTACGGATAAAACGCTGCGCTCACTGAAACATGGCGAAGC
CCTGCTGAAAATGGAGTGTTGTGGTGTATGTCATACCGATCTTCATGTTAAGAATGGCGATTTTGGTGATAAAACCGGCG
TGATTCTGGGCCATGAAGGCATCGGTGTGGTGGCAGAAGTTGGCCCCGGCGTTACCTCATTAAAACCAGGCGATCGCGCC
AGCGTGGCGTGGTTTTACGAAGGATGCGGTCATTGCGAATACTGTAACAGCGGTAACGAAACGCTCTGCCGTTCAGTAAA
AAATGCCGGATACAGCGTTGATGGCGGCATGGCGGAAGAGTGCATCGTGGTCGCCGATTACGCGGTTAAAGTGCCGGATG
GCCTGGACTCGGCGGCGGCCAGCAGCATCACCTGCGCGGGCGTCACCACCTACAAAGCAGTAAAACTATCAAAAATTCGT
CCAGGACAGTGGATTGCTATCTACGGTCTTGGCGGTCTGGGCAACCTCGCCCTGCAATACGCGAAAAATGTCTTTAATGC
AAAAGTGATCGCCATTGATGTCAATGATGAGCAGTTGAAACTGGCAACCGAAATAGGTGCTGATTTAGCGATTAACTCAC
GTACCGAAGACGCCGCCAAAATTGTGCAGGAGAAAACCGGTGGCGCTCACGCAGCGGTGGTGACAGCGGTAGCTAAAGCT
GCGTTTAACTCGGCAGTTGATGCTGTCCGTGCTGGCGGTCGTGTTGTGGCAGTCGGTCTGCCGCCGGAGTCTATGAGCCT
GGACATCCCACGGCTGGTGCTGGATGGTATTGAAGTGGTCGGTTCGCTAGTTGGCACGCGCCAGGATCTCACCGAAGCCT
TCCAGTTTGCCGCCGAAGGCAAAGTGGTGCCGAAAGTCGCCCTGCGTCCGTTAGCGGACATCAACACCATCTTTACTGAG
ATGGAAGAAGGCAAAATCCGTGGCCGTATGGTGATTGATTTCCGCCGCTAA

Upstream 100 bases:

>100_bases
TTTCCTCCTCTTTTTCAGAACTCATCCATACTGGGTAATGGCAAATAAATCTCATTTGCCTCACCTGCTATGCAGAACAT
CATCCGAAAAGGAGGAAACT

Downstream 100 bases:

>100_bases
GAAGCCTTTGCTGCGACTGCCATGTTCGGGTCGCAGCCTGTTTTGCGAGACGCTTTCCGCAATTTCACTCTTCTTCTTTT
CCTCCCCCATCTTTCCCCTC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKAAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIR
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEIGADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTE
MEEGKIRGRMVIDFRR

Sequences:

>Translated_336_residues
MKAAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIR
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEIGADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTE
MEEGKIRGRMVIDFRR
>Mature_336_residues
MKAAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEGIGVVAEVGPGVTSLKPGDRA
SVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEECIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIR
PGQWIAIYGLGGLGNLALQYAKNVFNAKVIAIDVNDEQLKLATEIGADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEGKVVPKVALRPLADINTIFTE
MEEGKIRGRMVIDFRR

Specific function: Preferred specificity is towards 1-propanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=316, Percent_Identity=32.2784810126582, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4501933, Length=352, Percent_Identity=30.1136363636364, Blast_Score=111, Evalue=8e-25,
Organism=Homo sapiens, GI4501929, Length=292, Percent_Identity=32.1917808219178, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI262073058, Length=299, Percent_Identity=28.7625418060201, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI71743840, Length=301, Percent_Identity=28.5714285714286, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI71565154, Length=227, Percent_Identity=32.5991189427313, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71565152, Length=297, Percent_Identity=28.2828282828283, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501939, Length=320, Percent_Identity=28.125, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI156523966, Length=324, Percent_Identity=28.7037037037037, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI156627571, Length=267, Percent_Identity=28.8389513108614, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=98.8095238095238, Blast_Score=672, Evalue=0.0,
Organism=Escherichia coli, GI1790045, Length=294, Percent_Identity=30.2721088435374, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87082401, Length=318, Percent_Identity=27.9874213836478, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1786518, Length=336, Percent_Identity=26.4880952380952, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787863, Length=269, Percent_Identity=29.7397769516729, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1788073, Length=259, Percent_Identity=30.1158301158301, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=26.5714285714286, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI226510992, Length=312, Percent_Identity=28.2051282051282, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790718, Length=331, Percent_Identity=26.8882175226586, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788075, Length=305, Percent_Identity=26.2295081967213, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786825, Length=278, Percent_Identity=27.6978417266187, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788407, Length=227, Percent_Identity=30.8370044052863, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988145, Length=313, Percent_Identity=37.3801916932907, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17562584, Length=329, Percent_Identity=35.5623100303951, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562582, Length=315, Percent_Identity=37.7777777777778, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17562878, Length=195, Percent_Identity=34.3589743589744, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562876, Length=254, Percent_Identity=30.3149606299213, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25146526, Length=218, Percent_Identity=31.1926605504587, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=205, Percent_Identity=31.7073170731707, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=205, Percent_Identity=31.219512195122, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=331, Percent_Identity=37.1601208459215, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6323961, Length=327, Percent_Identity=38.8379204892966, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6323729, Length=332, Percent_Identity=36.7469879518072, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6324486, Length=342, Percent_Identity=35.9649122807018, Blast_Score=198, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6319949, Length=323, Percent_Identity=27.8637770897833, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=315, Percent_Identity=26.984126984127, Blast_Score=105, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6320033, Length=235, Percent_Identity=32.3404255319149, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=314, Percent_Identity=27.0700636942675, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=314, Percent_Identity=27.0700636942675, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=348, Percent_Identity=24.4252873563218, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=217, Percent_Identity=26.7281105990783, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17137530, Length=212, Percent_Identity=30.6603773584906, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737897, Length=208, Percent_Identity=29.3269230769231, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737895, Length=226, Percent_Identity=29.2035398230088, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35352; Mature: 35352

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEEECCCCCCCHHHHHHHHHHCCCEEEHHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEE
CEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
CIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCCCHHHCCEEEECCCEEHEEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDEQLKLATEIGADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRR
CCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKAAVVTKDHHVDVTDKTLRSLKHGEALLKMECCGVCHTDLHVKNGDFGDKTGVILGHEG
CCCEEEECCCCCCCHHHHHHHHHHCCCEEEHHHCCCCCCCEEEECCCCCCCCCEEEECCC
IGVVAEVGPGVTSLKPGDRASVAWFYEGCGHCEYCNSGNETLCRSVKNAGYSVDGGMAEE
CEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
CIVVADYAVKVPDGLDSAAASSITCAGVTTYKAVKLSKIRPGQWIAIYGLGGLGNLALQY
EEEEEEEEEECCCCCCCHHHCCEEEECCCEEHEEEEEECCCCCEEEEEECCCHHHHHHHH
AKNVFNAKVIAIDVNDEQLKLATEIGADLAINSRTEDAAKIVQEKTGGAHAAVVTAVAKA
HHHHCCCEEEEEECCCCCEEEHHHCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHH
AFNSAVDAVRAGGRVVAVGLPPESMSLDIPRLVLDGIEVVGSLVGTRQDLTEAFQFAAEG
HHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
KVVPKVALRPLADINTIFTEMEEGKIRGRMVIDFRR
CCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 2158980 [H]