The gene/protein map for NC_011740 is currently unavailable.
Definition Escherichia fergusonii ATCC 35469 chromosome, complete genome.
Accession NC_011740
Length 4,588,711

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The map label for this gene is benD [H]

Identifier: 218548842

GI number: 218548842

Start: 1521461

End: 1522234

Strand: Direct

Name: benD [H]

Synonym: EFER_1485

Alternate gene names: 218548842

Gene position: 1521461-1522234 (Clockwise)

Preceding gene: 218548841

Following gene: 218548843

Centisome position: 33.16

GC content: 52.97

Gene sequence:

>774_bases
ATGCGATTTCAAAATAAAGTCATGGCGATAACCGGTGCAGCACAAGGCATCGGTCGGCAAACCGCTGAACAAGCAGCCCG
TGAAGGGGCGCGTTTGCTGCTGATTGATCGTTCTCGTTACGTTCATGAACTGGCCGCTACGCTGGCAAAGGCAGGTTGCG
ATGTTCTGGCGCTGGAAGCAGATCTCGAACAGTGGGAAAGCACCGGGCAGGCATTCGCAACAGGCGTCGCCCATTTTGGC
CGACTCGATATCCTGATTAATAACGTCGGCGGGACCATTTGGGCAAAACCTTTTGCTGAGTACCAACCGGAACAAATTGA
AAAAGAAGTGCGTCGATCTCTGTTTCCCACGCTTTGGGGGTGCCGTGCGGCATTACCCTGGATGCTACAACAGGGTAAAG
GAAGCATTGTGAATATCTCGTCAGTGGCGACAGCTGGTGTTAATCGTGTGCCATATTCGGCAGCAAAAGGTGGGGTCAAT
GCGTTAACCCGTTCTATCGCGATGGAATATAGTGGTAGTGGCATTCGGATTAATGCTGTTGCCCCTGGGGGAACAGATGC
CCCGACTCGTTTAACGCCTCGTAACGAAGAACAACCAACCGTTGAGGAGCAAGCCTGGTATCAGCAGGTCATTGATCAAA
CGCTGGCGAGTAGCTTGATGCATCGGTACGGTACACTGGCAGAGCAGGCGAATGCCATTTTGTTTCTCGCCAGCGACGAT
GCCAGCTATATCACCGGTGTTACGTTACCGGTTGCAGGGGGCGATCTGGGGTAA

Upstream 100 bases:

>100_bases
TGCCGTAGCAACGGCACTTCGCGAAAGAGGAATCTCCCCGGCAGGTTTCTGGTATGAAAAATTTATCGCCAGCCAGAGCG
CGGCGGCATAAGGAACAAAA

Downstream 100 bases:

>100_bases
GAGTCTCAAGGGTAATCTGGCAGGTATTGTCCATTGCTTCAACTTCTTTGCCCGTCAGGCGGGCATATTGACCTGTGAGA
TGCCAGAATTGCGGTTGCGT

Product: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

Products: NA

Alternate protein names: 2-hydro-1,2-dihydroxybenzoate dehydrogenase; DHB dehydrogenase; Cis-1,2-dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase; Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MRFQNKVMAITGAAQGIGRQTAEQAAREGARLLLIDRSRYVHELAATLAKAGCDVLALEADLEQWESTGQAFATGVAHFG
RLDILINNVGGTIWAKPFAEYQPEQIEKEVRRSLFPTLWGCRAALPWMLQQGKGSIVNISSVATAGVNRVPYSAAKGGVN
ALTRSIAMEYSGSGIRINAVAPGGTDAPTRLTPRNEEQPTVEEQAWYQQVIDQTLASSLMHRYGTLAEQANAILFLASDD
ASYITGVTLPVAGGDLG

Sequences:

>Translated_257_residues
MRFQNKVMAITGAAQGIGRQTAEQAAREGARLLLIDRSRYVHELAATLAKAGCDVLALEADLEQWESTGQAFATGVAHFG
RLDILINNVGGTIWAKPFAEYQPEQIEKEVRRSLFPTLWGCRAALPWMLQQGKGSIVNISSVATAGVNRVPYSAAKGGVN
ALTRSIAMEYSGSGIRINAVAPGGTDAPTRLTPRNEEQPTVEEQAWYQQVIDQTLASSLMHRYGTLAEQANAILFLASDD
ASYITGVTLPVAGGDLG
>Mature_257_residues
MRFQNKVMAITGAAQGIGRQTAEQAAREGARLLLIDRSRYVHELAATLAKAGCDVLALEADLEQWESTGQAFATGVAHFG
RLDILINNVGGTIWAKPFAEYQPEQIEKEVRRSLFPTLWGCRAALPWMLQQGKGSIVNISSVATAGVNRVPYSAAKGGVN
ALTRSIAMEYSGSGIRINAVAPGGTDAPTRLTPRNEEQPTVEEQAWYQQVIDQTLASSLMHRYGTLAEQANAILFLASDD
ASYITGVTLPVAGGDLG

Specific function: Degradation of 2-hydro-1,2-dihydroxy benzoate (DHB) to catechol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=30.1587301587302, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=29.8850574712644, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI32483357, Length=256, Percent_Identity=27.734375, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI31542939, Length=257, Percent_Identity=31.1284046692607, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=27.710843373494, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI66933014, Length=256, Percent_Identity=31.25, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI15277342, Length=264, Percent_Identity=28.7878787878788, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI10190704, Length=262, Percent_Identity=31.6793893129771, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI59889578, Length=197, Percent_Identity=30.4568527918782, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI210032110, Length=221, Percent_Identity=26.6968325791855, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI142976729, Length=248, Percent_Identity=27.8225806451613, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI224922801, Length=179, Percent_Identity=33.5195530726257, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI5031737, Length=256, Percent_Identity=26.5625, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI126723750, Length=262, Percent_Identity=24.8091603053435, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4758504, Length=190, Percent_Identity=31.0526315789474, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI4504505, Length=208, Percent_Identity=28.8461538461538, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=31.640625, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=30.7392996108949, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1789208, Length=258, Percent_Identity=29.0697674418605, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=30.7086614173228, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787905, Length=262, Percent_Identity=29.3893129770992, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=27.9527559055118, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=27.5590551181102, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=26.8939393939394, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=24.8062015503876, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786812, Length=264, Percent_Identity=30.6818181818182, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=31.8897637795276, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71994600, Length=257, Percent_Identity=31.9066147859922, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562910, Length=271, Percent_Identity=32.1033210332103, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=269, Percent_Identity=31.2267657992565, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=29.9625468164794, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=271, Percent_Identity=30.9963099630996, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17551412, Length=267, Percent_Identity=31.4606741573034, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=253, Percent_Identity=26.8774703557312, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=268, Percent_Identity=30.5970149253731, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=261, Percent_Identity=28.735632183908, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=30.3370786516854, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=30.1526717557252, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=194, Percent_Identity=29.8969072164948, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=27.6679841897233, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=189, Percent_Identity=30.6878306878307, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=268, Percent_Identity=30.5970149253731, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=191, Percent_Identity=29.3193717277487, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17538480, Length=265, Percent_Identity=30.9433962264151, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=193, Percent_Identity=32.6424870466321, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=275, Percent_Identity=28, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=275, Percent_Identity=27.6363636363636, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=195, Percent_Identity=29.7435897435897, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=25.3846153846154, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=236, Percent_Identity=27.5423728813559, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=189, Percent_Identity=30.1587301587302, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=187, Percent_Identity=28.3422459893048, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=178, Percent_Identity=29.7752808988764, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=261, Percent_Identity=30.6513409961686, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322861, Length=199, Percent_Identity=28.643216080402, Blast_Score=73, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=209, Percent_Identity=28.7081339712919, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24644339, Length=264, Percent_Identity=34.0909090909091, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571526, Length=262, Percent_Identity=33.206106870229, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI23397609, Length=261, Percent_Identity=31.4176245210728, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21357041, Length=262, Percent_Identity=31.6793893129771, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24644337, Length=262, Percent_Identity=34.7328244274809, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21355319, Length=268, Percent_Identity=30.2238805970149, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639444, Length=260, Percent_Identity=29.6153846153846, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24643142, Length=251, Percent_Identity=29.4820717131474, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737361, Length=200, Percent_Identity=32, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24580925, Length=197, Percent_Identity=31.4720812182741, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358495, Length=193, Percent_Identity=30.5699481865285, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21357673, Length=194, Percent_Identity=25.2577319587629, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.25 [H]

Molecular weight: Translated: 27546; Mature: 27546

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MRFQNKVMAITGAAQGIGRQTAEQAAREGARLLLIDRSRYVHELAATLAKAGCDVLALEA
CCCCCCEEEEECHHHHCCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEHH
DLEQWESTGQAFATGVAHFGRLDILINNVGGTIWAKPFAEYQPEQIEKEVRRSLFPTLWG
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHCCHHHHHHHHHHHHHHHHHH
CRAALPWMLQQGKGSIVNISSVATAGVNRVPYSAAKGGVNALTRSIAMEYSGSGIRINAV
HHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHEECCCCEEEEEE
APGGTDAPTRLTPRNEEQPTVEEQAWYQQVIDQTLASSLMHRYGTLAEQANAILFLASDD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
ASYITGVTLPVAGGDLG
CCEEEEEEEEECCCCCC
>Mature Secondary Structure
MRFQNKVMAITGAAQGIGRQTAEQAAREGARLLLIDRSRYVHELAATLAKAGCDVLALEA
CCCCCCEEEEECHHHHCCHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHCCCCEEEEHH
DLEQWESTGQAFATGVAHFGRLDILINNVGGTIWAKPFAEYQPEQIEKEVRRSLFPTLWG
HHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHCCHHHHHHHHHHHHHHHHHH
CRAALPWMLQQGKGSIVNISSVATAGVNRVPYSAAKGGVNALTRSIAMEYSGSGIRINAV
HHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHEECCCCEEEEEE
APGGTDAPTRLTPRNEEQPTVEEQAWYQQVIDQTLASSLMHRYGTLAEQANAILFLASDD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
ASYITGVTLPVAGGDLG
CCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1740120 [H]