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The map label for this gene is clcB [H]

Identifier: 218548805

GI number: 218548805

Start: 1486311

End: 1487609

Strand: Reverse

Name: clcB [H]

Synonym: EFER_1444

Alternate gene names: 218548805

Gene position: 1487609-1486311 (Counterclockwise)

Preceding gene: 218548806

Following gene: 218548800

Centisome position: 32.42

GC content: 50.81

Gene sequence:

>1299_bases
TTGTCTTACGCAACAATGTACCCACGTCCTATTTTTGCTAATCCACGAACACTATTTCGCCATTTGCTTATTGCCTCTTT
TATAGGTGTTGTTGCCGCCATGGCTGTCGCCGGGTTTCGGCATGCCATGTTGTTGCTTGAATGGTTATTTCTCAGTAACA
ACTCCGGTAGCCTGGTCAACGCGGCGACAGAACTTTCTGGCTGGCGAAGAGTATTAACACCGGCCTCAGGTGGACTGGCT
GCGGGAGCACTCCTCTGGGGCTGGCAAAAATTAAATCGCCAGAGACCTCATGCACCTTGTGATTATATGGAGGCACTGCA
AACCGATGGGCAATTTGATTATGCAACCAGTCTGGTGAAGTCACTTGCATCTTTGTTAGTCGTCGCAAGCGGCAGTGCGA
TTGGTCGGGAAGGTGCCATGATCTTGCTGGCTTCACTGGCCGCATCGTTTCTGGCGAAGCGTTTCACGCCAGCCGAAGAG
TGGAAATTATGGATTGCCTGCGGAGCATCAGCAGGAATGGCAAGTGCTTATCACGCCCCGTTAGCAGGAAGTCTGTTTAT
TGCCGAAATTCTCTTTGGCACCTTTTTGCTGACCTCACTCGGCCCGGTGATTATTTCTGCGGTGGTAGCTTTGCTCACCA
CTTATTTATTTAACGGGGGTAGCGCCCTGCTCTACCACGTGCCTGCTACGCTGGAAATTCACACTAGCGACTATTTATTG
GTGGTGTGTTGTGGTCTGCTGATGGGAATAAGCGGCCCACTGCTACTGGCGTTAATGCGCATCAGCCACAATGGTTTTCT
GCGCTTGAAATTATCCCCTCCATGTCAACTGGCATTGGGCGGGTTGTGTGTGGGTTTGCTTTCGTTAATGACGCCCACGG
TCTGGGGTAATGGCTACAGCGTGGTACAAGCATTCTTACTTTCGCCCCCCTTGTTGACTGTAATAGCGGGGATTTTTATC
TGTAAATTACTGGCGGTACTTGCCAGTAGTGGCTCCGGCGCGCCAGGTGGCGTTTTTACGCCTACCCTGTTTATTGGCCT
GGCAATTGGCATGATCTTTGGGCGTGTACTGGGGCAAGGCCCTGATGCTCAGGTTATTTTGCTGGGATTAAGTGGCATGG
CGACGCTGCTGGCGGCAACCACTCATGCGCCAATTATGTCGACATTAATGATTTGCGAAATGACCGGAGAGTATCAACTA
CTCCCCGGTTTATTGCTGGCATGTGTATTAGCGACGGTGATTTCGCGATCGTTACATCCCGATTCTATTTACCGACAACA
CCCGGTCGAGCATAGATAA

Upstream 100 bases:

>100_bases
AACCAGGTATGCCTGGTAACTTCCTGTTACCGGGCTAAATACGCACGTAGTGCTTTTGCCTTAATGCTGCTTTCACCGCA
AAATATTCCTTCTGTCTCCT

Downstream 100 bases:

>100_bases
ACGAATATATTGCCCCAGTTCGCGTTGCTCAGCACGAGGCAGATAAGGCAATTCACCAATCAATGGCGCAGGAATTTTTT
TGCTCAGCACATCAATAATT

Product: voltage-gated ClC-type chloride channel ClcB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSYATMYPRPIFANPRTLFRHLLIASFIGVVAAMAVAGFRHAMLLLEWLFLSNNSGSLVNAATELSGWRRVLTPASGGLA
AGALLWGWQKLNRQRPHAPCDYMEALQTDGQFDYATSLVKSLASLLVVASGSAIGREGAMILLASLAASFLAKRFTPAEE
WKLWIACGASAGMASAYHAPLAGSLFIAEILFGTFLLTSLGPVIISAVVALLTTYLFNGGSALLYHVPATLEIHTSDYLL
VVCCGLLMGISGPLLLALMRISHNGFLRLKLSPPCQLALGGLCVGLLSLMTPTVWGNGYSVVQAFLLSPPLLTVIAGIFI
CKLLAVLASSGSGAPGGVFTPTLFIGLAIGMIFGRVLGQGPDAQVILLGLSGMATLLAATTHAPIMSTLMICEMTGEYQL
LPGLLLACVLATVISRSLHPDSIYRQHPVEHR

Sequences:

>Translated_432_residues
MSYATMYPRPIFANPRTLFRHLLIASFIGVVAAMAVAGFRHAMLLLEWLFLSNNSGSLVNAATELSGWRRVLTPASGGLA
AGALLWGWQKLNRQRPHAPCDYMEALQTDGQFDYATSLVKSLASLLVVASGSAIGREGAMILLASLAASFLAKRFTPAEE
WKLWIACGASAGMASAYHAPLAGSLFIAEILFGTFLLTSLGPVIISAVVALLTTYLFNGGSALLYHVPATLEIHTSDYLL
VVCCGLLMGISGPLLLALMRISHNGFLRLKLSPPCQLALGGLCVGLLSLMTPTVWGNGYSVVQAFLLSPPLLTVIAGIFI
CKLLAVLASSGSGAPGGVFTPTLFIGLAIGMIFGRVLGQGPDAQVILLGLSGMATLLAATTHAPIMSTLMICEMTGEYQL
LPGLLLACVLATVISRSLHPDSIYRQHPVEHR
>Mature_431_residues
SYATMYPRPIFANPRTLFRHLLIASFIGVVAAMAVAGFRHAMLLLEWLFLSNNSGSLVNAATELSGWRRVLTPASGGLAA
GALLWGWQKLNRQRPHAPCDYMEALQTDGQFDYATSLVKSLASLLVVASGSAIGREGAMILLASLAASFLAKRFTPAEEW
KLWIACGASAGMASAYHAPLAGSLFIAEILFGTFLLTSLGPVIISAVVALLTTYLFNGGSALLYHVPATLEIHTSDYLLV
VCCGLLMGISGPLLLALMRISHNGFLRLKLSPPCQLALGGLCVGLLSLMTPTVWGNGYSVVQAFLLSPPLLTVIAGIFIC
KLLAVLASSGSGAPGGVFTPTLFIGLAIGMIFGRVLGQGPDAQVILLGLSGMATLLAATTHAPIMSTLMICEMTGEYQLL
PGLLLACVLATVISRSLHPDSIYRQHPVEHR

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=417, Percent_Identity=75.5395683453237, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI1786350, Length=253, Percent_Identity=28.8537549407115, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 45622; Mature: 45491

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYATMYPRPIFANPRTLFRHLLIASFIGVVAAMAVAGFRHAMLLLEWLFLSNNSGSLVN
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AATELSGWRRVLTPASGGLAAGALLWGWQKLNRQRPHAPCDYMEALQTDGQFDYATSLVK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
SLASLLVVASGSAIGREGAMILLASLAASFLAKRFTPAEEWKLWIACGASAGMASAYHAP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCEEEEEECCCCCCCHHHCCC
LAGSLFIAEILFGTFLLTSLGPVIISAVVALLTTYLFNGGSALLYHVPATLEIHTSDYLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCHHH
VVCCGLLMGISGPLLLALMRISHNGFLRLKLSPPCQLALGGLCVGLLSLMTPTVWGNGYS
HHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHH
VVQAFLLSPPLLTVIAGIFICKLLAVLASSGSGAPGGVFTPTLFIGLAIGMIFGRVLGQG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PDAQVILLGLSGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLLACVLATVISRSLHP
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
DSIYRQHPVEHR
CHHHHCCCCCCC
>Mature Secondary Structure 
SYATMYPRPIFANPRTLFRHLLIASFIGVVAAMAVAGFRHAMLLLEWLFLSNNSGSLVN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AATELSGWRRVLTPASGGLAAGALLWGWQKLNRQRPHAPCDYMEALQTDGQFDYATSLVK
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
SLASLLVVASGSAIGREGAMILLASLAASFLAKRFTPAEEWKLWIACGASAGMASAYHAP
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCEEEEEECCCCCCCHHHCCC
LAGSLFIAEILFGTFLLTSLGPVIISAVVALLTTYLFNGGSALLYHVPATLEIHTSDYLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCHHH
VVCCGLLMGISGPLLLALMRISHNGFLRLKLSPPCQLALGGLCVGLLSLMTPTVWGNGYS
HHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCHH
VVQAFLLSPPLLTVIAGIFICKLLAVLASSGSGAPGGVFTPTLFIGLAIGMIFGRVLGQG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PDAQVILLGLSGMATLLAATTHAPIMSTLMICEMTGEYQLLPGLLLACVLATVISRSLHP
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
DSIYRQHPVEHR
CHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA