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The map label for this gene is dgsA [H]

Identifier: 218548803

GI number: 218548803

Start: 1484318

End: 1485538

Strand: Direct

Name: dgsA [H]

Synonym: EFER_1442

Alternate gene names: 218548803

Gene position: 1484318-1485538 (Clockwise)

Preceding gene: 218548802

Following gene: 218548804

Centisome position: 32.35

GC content: 49.55

Gene sequence:

>1221_bases
GTGGTTGCTGAAAGTCAGCCAGGGCATATCGATCAAATTAAGCAAACTAACGCAGGTGCGGTCTATCGCCTGATAGATCA
GCTTGGCCCGGTTTCGCGGATCGATCTTTCTCGTCTGGCGCAACTGGCACCAGCCAGTATTACAAAAATCGTGCGCGAAA
TGCTCGAAGCGCATTTGGTGCAGGAGCTGGAGATCAAAGAAGCGGGGAACCGGGGACGACCTGCGGTTGGTCTGGTGGTT
GAAACCGAAGCCTGGCACTATCTTTCTATCCGAATTGGCCGTGGCGAGATATTCCTTGCGCTGCGCGATCTTAGTAGCAA
ATTGGTTGTCGAGGATCGCCTCGATTTGCCGCTACAGTCTGAAACGCCATTATTACAACGCATTCTCCATCAGGTTGATC
AATTTTTTATTCGTCATCAGCAGAAACTGGAGCGATTGACGTCCATCGCCATAACCATGCCCGGAATCATTGATACTGAG
AATGGAATTGTGCACCGAATGCCGTTTTATGATGATGTTAAAGAGATGCCCTTGGGAGCTGCATTAGAAACGCATACTGG
TGTTCCTGTTTATATTCAACATGATATCAGTGCCTGGACGATGGCTGAGGCGTTATTTGGTGCTTCCCGTGGCGCGCGCG
ATGTCATCCAGGTGGTGATTGATCACAACGTAGGTGCCGGAGTGATCACCGATGGGCATTTACTTCACGCGGGGAGCAGT
AGCCTGGTTGAAATTGGCCATACCCAGGTAGATCCTTATGGCAAACGCTGTTACTGCGGCAACCACGGATGCCTTGAAAC
TATTGCCAGTGTTGATAGCGTACTGGAACTGGCTCAGTTGCGACTGAATCAGTCGATGAGTTCGATATTGCATGGTCAGC
CACTGACTGTAGACTCGTTGTGTCAGGCTGCTTTGCTCGGTGACTTGCTGGCGCGGGATATTATTACCGGTGTTGGTCAG
CATGTGGGGCGTATCCTCGCCATTATGGTGAATTTATTCAACCCGCAAAAAATACTTATTGGATCACCCCTAAACAAAGC
TGCTGAGGTGCTTTTCCCGGCGATATCCAATAGCATTCGTCAACAGGCACTTCCGGCCTATAGTCAACATATGACTGTAG
AAAGTACCCAATTTACCAATCAGGGAACCATGGCGGGAGCAGCACTGGTAAAAGACGCGATGTATAGCGGCTCTTTGTTG
ATTCGTCTATTACAGGGTTAA

Upstream 100 bases:

>100_bases
GTCAAATCACACGGCTAAGTAAAATTTTTCCGTTACGTGTTGAAGTGCTTCACCATAACCGACAAATTATTTCGGAGCGC
GAAAATATAGGGAGTCAGAG

Downstream 100 bases:

>100_bases
CATTTTTTAACTGTTCTACGAAAATTTGCGCTAACTCAATCTGAATCTCATCGCCTTAACTTAGACTTTTCTATCGTTTT
ATTAATCTGGCTTATATTTT

Product: DNA-binding transcriptional repressor

Products: NA

Alternate protein names: Making large colonies protein [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MVAESQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLVQELEIKEAGNRGRPAVGLVV
ETEAWHYLSIRIGRGEIFLALRDLSSKLVVEDRLDLPLQSETPLLQRILHQVDQFFIRHQQKLERLTSIAITMPGIIDTE
NGIVHRMPFYDDVKEMPLGAALETHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELAQLRLNQSMSSILHGQPLTVDSLCQAALLGDLLARDIITGVGQ
HVGRILAIMVNLFNPQKILIGSPLNKAAEVLFPAISNSIRQQALPAYSQHMTVESTQFTNQGTMAGAALVKDAMYSGSLL
IRLLQG

Sequences:

>Translated_406_residues
MVAESQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLVQELEIKEAGNRGRPAVGLVV
ETEAWHYLSIRIGRGEIFLALRDLSSKLVVEDRLDLPLQSETPLLQRILHQVDQFFIRHQQKLERLTSIAITMPGIIDTE
NGIVHRMPFYDDVKEMPLGAALETHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELAQLRLNQSMSSILHGQPLTVDSLCQAALLGDLLARDIITGVGQ
HVGRILAIMVNLFNPQKILIGSPLNKAAEVLFPAISNSIRQQALPAYSQHMTVESTQFTNQGTMAGAALVKDAMYSGSLL
IRLLQG
>Mature_406_residues
MVAESQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLVQELEIKEAGNRGRPAVGLVV
ETEAWHYLSIRIGRGEIFLALRDLSSKLVVEDRLDLPLQSETPLLQRILHQVDQFFIRHQQKLERLTSIAITMPGIIDTE
NGIVHRMPFYDDVKEMPLGAALETHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELAQLRLNQSMSSILHGQPLTVDSLCQAALLGDLLARDIITGVGQ
HVGRILAIMVNLFNPQKILIGSPLNKAAEVLFPAISNSIRQQALPAYSQHMTVESTQFTNQGTMAGAALVKDAMYSGSLL
IRLLQG

Specific function: Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=227, Percent_Identity=26.8722466960352, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI190014632, Length=227, Percent_Identity=26.8722466960352, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI298566325, Length=227, Percent_Identity=26.8722466960352, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4885285, Length=227, Percent_Identity=26.8722466960352, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787878, Length=406, Percent_Identity=91.1330049261084, Blast_Score=764, Evalue=0.0,
Organism=Escherichia coli, GI1786891, Length=402, Percent_Identity=40.0497512437811, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI87082127, Length=333, Percent_Identity=24.024024024024, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787363, Length=320, Percent_Identity=23.75, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 44272; Mature: 44272

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAESQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLV
CCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
QELEIKEAGNRGRPAVGLVVETEAWHYLSIRIGRGEIFLALRDLSSKLVVEDRLDLPLQS
HHHHHHHCCCCCCCEEEEEEECCCEEEEEEEECCCEEEEEEECCCCCEEEHHCCCCCCCC
ETPLLQRILHQVDQFFIRHQQKLERLTSIAITMPGIIDTENGIVHRMPFYDDVKEMPLGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCEEECCCHHHHHHCCCCC
ALETHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
CHHCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCEEEECCCC
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELAQLRLNQSMSSILHGQPLTVDSL
CCEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
CQAALLGDLLARDIITGVGQHVGRILAIMVNLFNPQKILIGSPLNKAAEVLFPAISNSIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
QQALPAYSQHMTVESTQFTNQGTMAGAALVKDAMYSGSLLIRLLQG
HHHCCHHHHCCEEECCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure
MVAESQPGHIDQIKQTNAGAVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLV
CCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
QELEIKEAGNRGRPAVGLVVETEAWHYLSIRIGRGEIFLALRDLSSKLVVEDRLDLPLQS
HHHHHHHCCCCCCCEEEEEEECCCEEEEEEEECCCEEEEEEECCCCCEEEHHCCCCCCCC
ETPLLQRILHQVDQFFIRHQQKLERLTSIAITMPGIIDTENGIVHRMPFYDDVKEMPLGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCEEECCCHHHHHHCCCCC
ALETHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS
CHHCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEECCEEEECCCC
SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELAQLRLNQSMSSILHGQPLTVDSL
CCEECCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
CQAALLGDLLARDIITGVGQHVGRILAIMVNLFNPQKILIGSPLNKAAEVLFPAISNSIR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHH
QQALPAYSQHMTVESTQFTNQGTMAGAALVKDAMYSGSLLIRLLQG
HHHCCHHHHCCEEECCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7766024; 9097039; 9278503 [H]