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The map label for this gene is kdgR [H]

Identifier: 218548613

GI number: 218548613

Start: 1288229

End: 1289011

Strand: Direct

Name: kdgR [H]

Synonym: EFER_1247

Alternate gene names: 218548613

Gene position: 1288229-1289011 (Clockwise)

Preceding gene: 218548611

Following gene: 218548615

Centisome position: 28.07

GC content: 45.59

Gene sequence:

>783_bases
ATGGCCAGTACAGATCTGGGTAAACAACCTGATTCTGTTTCTTCCGTGTTGAAAGTTTTCGGTATTTTACAGGCATTAGG
CGAAGAGCGTGAAATTGGTATTACCGAGCTTTCTCAACGCGTTATGATGTCAAAAAGTACCGTTTATCGCTTTTTGCAAA
CCATGAAAACGTTGGGCTATGTTGCTCAGGAGGGGGAGTCAGAAAAATATTCCCTGACGTTGAAATTATTCGAACTGGGT
GCCCGTGCATTACAAAATGTCGATTTGATTCGTAGCGCAGATATTCAAATGCGCGAACTTTCCAGACTTACCAAAGAAAC
CATTCACCTTGGCGCGCTGGACGAAGACAGCATTGTCTATATTCATAAAATCGACTCCATGTACAATTTACGTATGTACT
CCCGTATTGGTCGTCGAAATCCGCTCTACAGCACCGCAATTGGTAAAGTCTTGCTGGCATGGCGTGACCATAAAGAAATC
AAACAAATCCTGGAACACGTCGAATATAAGCGGAGTACCGAGCGCACCATTACTACTACTGAAGCGTTACTGCCTGTGCT
GGATCAAGTTCGTGCTCAGGGCTATGGTGAAGACAATGAAGAGCAGGAAGCAGGGCTGCGTTGTATTGCTGTCCCGGTAT
TCGACCGCTTTGGCGTGGTGATCGCTGGCCTGAGTATTTCATTCCCTACACTGCGTTTCTCACAAGAACGCTTGCAGGAG
TATGTCGCTATTTTGCAGAATGCAGCGCGGAAAATTTCAGCTCAAATGGGATACATAGGCTAA

Upstream 100 bases:

>100_bases
TTGTAACGAAGCGGCAAAACTTGCATTGCGACGCCAGGATCGTGAATTTATAATAAAATTCGGTTCTGATTTTTCTAAAA
CACTCGCAATGAGGTGATGA

Downstream 100 bases:

>100_bases
ATATTTCGAGTTGCAGCACATGCAATTTGAAGTATGGCGATTATGACCAATATACTTTTGATATTGAAATTGCAGTCGAT
AAAAAACCTGCCAGCAGTCC

Product: DNA-binding transcriptional repressor KdgR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MASTDLGKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELG
ARALQNVDLIRSADIQMRELSRLTKETIHLGALDEDSIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDHKEI
KQILEHVEYKRSTERTITTTEALLPVLDQVRAQGYGEDNEEQEAGLRCIAVPVFDRFGVVIAGLSISFPTLRFSQERLQE
YVAILQNAARKISAQMGYIG

Sequences:

>Translated_260_residues
MASTDLGKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELG
ARALQNVDLIRSADIQMRELSRLTKETIHLGALDEDSIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDHKEI
KQILEHVEYKRSTERTITTTEALLPVLDQVRAQGYGEDNEEQEAGLRCIAVPVFDRFGVVIAGLSISFPTLRFSQERLQE
YVAILQNAARKISAQMGYIG
>Mature_259_residues
ASTDLGKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGYVAQEGESEKYSLTLKLFELGA
RALQNVDLIRSADIQMRELSRLTKETIHLGALDEDSIVYIHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDHKEIK
QILEHVEYKRSTERTITTTEALLPVLDQVRAQGYGEDNEEQEAGLRCIAVPVFDRFGVVIAGLSISFPTLRFSQERLQEY
VAILQNAARKISAQMGYIG

Specific function: Transcriptional repressor of genes involved in pectinolysis and in pectinase secretion. Controls all the genes involved in pectin catabolism, including the pel genes encoding pectate lyases, kdgT which encodes the 2-keto-3-deoxygluconate transport system

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=258, Percent_Identity=94.5736434108527, Blast_Score=496, Evalue=1e-142,
Organism=Escherichia coli, GI1786468, Length=247, Percent_Identity=41.2955465587045, Blast_Score=177, Evalue=9e-46,
Organism=Escherichia coli, GI1789999, Length=228, Percent_Identity=33.7719298245614, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI87082359, Length=248, Percent_Identity=28.6290322580645, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790752, Length=224, Percent_Identity=31.6964285714286, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786715, Length=224, Percent_Identity=29.4642857142857, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788581, Length=216, Percent_Identity=31.0185185185185, Blast_Score=104, Evalue=5e-24,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29456; Mature: 29325

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTDLGKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAQEGESEKYSLTLKLFELGARALQNVDLIRSADIQMRELSRLTKETIHLGALDEDSIVY
HHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEE
IHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDHKEIKQILEHVEYKRSTERTITTT
EEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHH
EALLPVLDQVRAQGYGEDNEEQEAGLRCIAVPVFDRFGVVIAGLSISFPTLRFSQERLQE
HHHHHHHHHHHHCCCCCCCCHHHHCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YVAILQNAARKISAQMGYIG
HHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ASTDLGKQPDSVSSVLKVFGILQALGEEREIGITELSQRVMMSKSTVYRFLQTMKTLGY
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAQEGESEKYSLTLKLFELGARALQNVDLIRSADIQMRELSRLTKETIHLGALDEDSIVY
HHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEE
IHKIDSMYNLRMYSRIGRRNPLYSTAIGKVLLAWRDHKEIKQILEHVEYKRSTERTITTT
EEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHH
EALLPVLDQVRAQGYGEDNEEQEAGLRCIAVPVFDRFGVVIAGLSISFPTLRFSQERLQE
HHHHHHHHHHHHCCCCCCCCHHHHCCEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
YVAILQNAARKISAQMGYIG
HHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1840643; 1545709 [H]