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The map label for this gene is tyrP [H]

Identifier: 218548489

GI number: 218548489

Start: 1159458

End: 1160696

Strand: Reverse

Name: tyrP [H]

Synonym: EFER_1117

Alternate gene names: 218548489

Gene position: 1160696-1159458 (Counterclockwise)

Preceding gene: 218548491

Following gene: 218548481

Centisome position: 25.29

GC content: 49.23

Gene sequence:

>1239_bases
ATGAATTGTTCCAGGACAGAAGAAAGCGTGAAAAACAGAACTCTGGGAAGTGTTTTTATCGTGGCAGGAACCACAATTGG
CGCGGGTATGCTGGCAATGCCCCTTGCCGCTGCCGGTGTTGGCTTTAGCGTGACACTGGTATTGTTGATCGGACTGTGGG
CATTAATGTGTTACACCGCATTGTTATTGCTGGAAGTTTATCAACACGTTCCGGCAGATACCGGGCTTGGTAGTCTGGCG
AAGCGCTATCTGGGACGCTACGGTCAATGGGTGACTGGCTTCAGTATGATGTTTTTAATGTACGCCCTGACCGCAGCCTA
TATTAGTGGTGCGGGGGAGTTGTTAGCTTCCAGTATTACAGACTGGACAGGCCGTGAAATCTCTCCGGCAGCTGGCGTGC
TGCTGTTCACCTTTGTTGCCGGTGGAGTAGTGTGCGTGGGCACGTCGTTAGTGGACCTGTTCAACCGTTTTCTCTTCACT
GCAAAAATTATTTTTCTTGTGGTTATGCTGGCGCTACTGATGCCGCATATTCACCAGATTAATCTACTAACTTTACCGGT
TGAACAAGGACTGGCTTTATCTGCTATTCCGGTTATTTTCACCTCGTTTGGCTTTCACGGCAGCGTGCCAAGTATTGTCA
GCTATATGGAAGGGAATATTCGGAAGCTACGCTGGGTGTTTATTACCGGCAGTGCGATTCCTCTTATTGCCTATATATTC
TTGCAACTGGCGACACTCGGCAGTATTAATTCCAGTACTTTTTTAGGCTTGTTAGCTAATCATGCCGGGCTGAACGGATT
ATTACAGGCGCTACGTGAAGTTGTGGCCTCGCCACATGTGGAACTGGCTGTACATCTGTTTGCTGATTTAGCATTGGCGA
CTTCATTTTTGGGGGTATCGCTGGGGCTTTTTGATTATCTGGCAGATCTGTTCCAACGGAGAAACAACGCCAGTGGTCGA
CTGCAAACCGGGGTCATCACTTTTTTACCCCCGCTGGCTTTTGCCCTCTTCTATCCGCGTGGTTTTGTCATGGCGTTAGG
ATATGCAGGTGTGGCATTGGCTGTTCTGGCCCTGTTAATTCCTTCTTTGTTAGCCTGGCAAAGCCGTAAGCGCTTCCCGG
AAACTACGTGGCGAGTGGCGGGTGGAACACCTATGCTGGTAATTGTATTTATTTGCGGCGTCGCGGTGATCGGCATTCAG
TTTATGATTGCAGCAGGATTGCTACCCGAGGTGGGATAA

Upstream 100 bases:

>100_bases
GCATTTTTTGCTTTTCATTGTAAACATTTTTATACAGAGCATGTAACGGTGATTTGACGAAATTAAGCGGATACCGTACT
CTGCGCCGCAGAAGTCTCTA

Downstream 100 bases:

>100_bases
AAACAAGGCCCGAGAGTCGTGCTTTCGGGCCTTTAATGATTAATGCAAGCAGCACTGTTTAAATTTCTTGCCGCTACCAC
ACGGACAAGGATCATTACGT

Product: tyrosine transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MNCSRTEESVKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLVLLIGLWALMCYTALLLLEVYQHVPADTGLGSLA
KRYLGRYGQWVTGFSMMFLMYALTAAYISGAGELLASSITDWTGREISPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFT
AKIIFLVVMLALLMPHIHQINLLTLPVEQGLALSAIPVIFTSFGFHGSVPSIVSYMEGNIRKLRWVFITGSAIPLIAYIF
LQLATLGSINSSTFLGLLANHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVSLGLFDYLADLFQRRNNASGR
LQTGVITFLPPLAFALFYPRGFVMALGYAGVALAVLALLIPSLLAWQSRKRFPETTWRVAGGTPMLVIVFICGVAVIGIQ
FMIAAGLLPEVG

Sequences:

>Translated_412_residues
MNCSRTEESVKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLVLLIGLWALMCYTALLLLEVYQHVPADTGLGSLA
KRYLGRYGQWVTGFSMMFLMYALTAAYISGAGELLASSITDWTGREISPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFT
AKIIFLVVMLALLMPHIHQINLLTLPVEQGLALSAIPVIFTSFGFHGSVPSIVSYMEGNIRKLRWVFITGSAIPLIAYIF
LQLATLGSINSSTFLGLLANHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVSLGLFDYLADLFQRRNNASGR
LQTGVITFLPPLAFALFYPRGFVMALGYAGVALAVLALLIPSLLAWQSRKRFPETTWRVAGGTPMLVIVFICGVAVIGIQ
FMIAAGLLPEVG
>Mature_412_residues
MNCSRTEESVKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLVLLIGLWALMCYTALLLLEVYQHVPADTGLGSLA
KRYLGRYGQWVTGFSMMFLMYALTAAYISGAGELLASSITDWTGREISPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFT
AKIIFLVVMLALLMPHIHQINLLTLPVEQGLALSAIPVIFTSFGFHGSVPSIVSYMEGNIRKLRWVFITGSAIPLIAYIF
LQLATLGSINSSTFLGLLANHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVSLGLFDYLADLFQRRNNASGR
LQTGVITFLPPLAFALFYPRGFVMALGYAGVALAVLALLIPSLLAWQSRKRFPETTWRVAGGTPMLVIVFICGVAVIGIQ
FMIAAGLLPEVG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=88.0893300248139, Blast_Score=698, Evalue=0.0,
Organism=Escherichia coli, GI1789552, Length=384, Percent_Identity=33.3333333333333, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1790145, Length=412, Percent_Identity=31.5533980582524, Blast_Score=201, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43986; Mature: 43986

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCSRTEESVKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLVLLIGLWALMCYTA
CCCCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLLLEVYQHVPADTGLGSLAKRYLGRYGQWVTGFSMMFLMYALTAAYISGAGELLASSIT
HHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DWTGREISPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFTAKIIFLVVMLALLMPHIHQI
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC
NLLTLPVEQGLALSAIPVIFTSFGFHGSVPSIVSYMEGNIRKLRWVFITGSAIPLIAYIF
EEEEEEHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHH
LQLATLGSINSSTFLGLLANHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVS
HHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LGLFDYLADLFQRRNNASGRLQTGVITFLPPLAFALFYPRGFVMALGYAGVALAVLALLI
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
PSLLAWQSRKRFPETTWRVAGGTPMLVIVFICGVAVIGIQFMIAAGLLPEVG
HHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNCSRTEESVKNRTLGSVFIVAGTTIGAGMLAMPLAAAGVGFSVTLVLLIGLWALMCYTA
CCCCCHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LLLLEVYQHVPADTGLGSLAKRYLGRYGQWVTGFSMMFLMYALTAAYISGAGELLASSIT
HHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DWTGREISPAAGVLLFTFVAGGVVCVGTSLVDLFNRFLFTAKIIFLVVMLALLMPHIHQI
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHC
NLLTLPVEQGLALSAIPVIFTSFGFHGSVPSIVSYMEGNIRKLRWVFITGSAIPLIAYIF
EEEEEEHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHH
LQLATLGSINSSTFLGLLANHAGLNGLLQALREVVASPHVELAVHLFADLALATSFLGVS
HHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
LGLFDYLADLFQRRNNASGRLQTGVITFLPPLAFALFYPRGFVMALGYAGVALAVLALLI
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
PSLLAWQSRKRFPETTWRVAGGTPMLVIVFICGVAVIGIQFMIAAGLLPEVG
HHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]