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The map label for this gene is nupC [H]

Identifier: 218233358

GI number: 218233358

Start: 354667

End: 355863

Strand: Reverse

Name: nupC [H]

Synonym: BCB4264_A0379

Alternate gene names: 218233358

Gene position: 355863-354667 (Counterclockwise)

Preceding gene: 218231711

Following gene: 218231900

Centisome position: 6.57

GC content: 35.92

Gene sequence:

>1197_bases
ATGCAATATGTAATGAGCATTATCGGTATTCTTGCCGTGTTAGGTTTATGTTTTGCTTTGTCAAACAACAAAAGTAAAAT
CAACTTCCGTGCAATTGCAATTATGATTGGTTTCCAAATTTTAATCGGTTGGTTTATGTTTGCTACAAAGATTGGTCAAC
AAATCATTATTTTCATTAGTAAAGTTTTCAACAAACTAATTAAACTTGGTACGACAGGTGTCGATTTTCTCTTTAATGGA
ATTCACAGAGATTTTGTCTTTTTCTTAAACGTATTATTAATTATCGTATTTTTCTCAGCACTACTTTCAATCTTTAGTTA
TTTAGGTGTTTTACCATTCATCGTTCGCGTTGTCGGCGGTGCTATTTCAAAAATTACTGGTTTACCACGTGTTGAGTCAT
TCCACGCAGTAAACTCTGTATTCTTCGGTTCAAGTGAAGCGTTAATCGTTATTAAAAACGATTTACAGCATTTCAATAAA
AATCGTATGTTTATCATTTGTTGTTCTGCGATGAGCTCCGTTTCTGCTTCTGTTACAGCATCATACGTAATGATGTTAGA
TGCAAAATACGTACTGGCAGCTCTTCCGCTAAACTTATTCTCAAGCTTAATCGTTTGTTCGTTATTAACACCAGTTGATA
CGAAGAAAGAAGATGAAGTGATTCAGAAATTTGATAGAACTCTATTCGGAGACAGCTTTATCGGCGCAATGATTAACGGT
GCGCTTGATGGTTTAAAAGTAGCTGGTATCGTTGCCGCATTAATGATCGCCTTTATCGGTGTGATGGAAGTTGTAAACTA
CGTAATTAGTGCAGCTTCAGGCGCAATGGGACATGCTGTTACTTTACAACAAATATTCGGTTACGTACTTTCTCCATTCG
CATTCTTAATGGGTATTCCAACTCAAGATATTATCCCAGCTGGTGGTATTATGGGTACGAAGATTGTTTTAAATGAGTTT
GTAGCAATCCTTGATTTAAAAGACACAGCTACAACATTAGCTCCACGTACAGTTGGAATCGTTACAGTATTCTTAATTAG
CTTCGCAAGTATTAGCCAAATTGGTGCAATCGTTGGTACAATCCGTGCCCTTTCTGAAAAACAAGGAAGCGTTGTTTCTA
AATTTGGTTGGAAAATGCTATTTGCATCAACACTTGCTTCTATTTTATCTGCGACAATCGCTGGATTGTTTATTTAA

Upstream 100 bases:

>100_bases
ACATCTTACGTATGACATAAAACCTCGTTCTTTTATTTTTAGTAATATAACGAGCGTTTTATGTACAAACTTTATACGAA
CTTCTGAAAGGGGCAACTAC

Downstream 100 bases:

>100_bases
TAAAAAATCACCTTACTTTAACAAGTAAGGTGATTTTTTTGATTCTTTATGAAATCGAGTGAAATTCAACTGCTTCTTCT
GTATTGATAATCCTATCTTT

Product: nucleoside transporter, NupC family

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQYVMSIIGILAVLGLCFALSNNKSKINFRAIAIMIGFQILIGWFMFATKIGQQIIIFISKVFNKLIKLGTTGVDFLFNG
IHRDFVFFLNVLLIIVFFSALLSIFSYLGVLPFIVRVVGGAISKITGLPRVESFHAVNSVFFGSSEALIVIKNDLQHFNK
NRMFIICCSAMSSVSASVTASYVMMLDAKYVLAALPLNLFSSLIVCSLLTPVDTKKEDEVIQKFDRTLFGDSFIGAMING
ALDGLKVAGIVAALMIAFIGVMEVVNYVISAASGAMGHAVTLQQIFGYVLSPFAFLMGIPTQDIIPAGGIMGTKIVLNEF
VAILDLKDTATTLAPRTVGIVTVFLISFASISQIGAIVGTIRALSEKQGSVVSKFGWKMLFASTLASILSATIAGLFI

Sequences:

>Translated_398_residues
MQYVMSIIGILAVLGLCFALSNNKSKINFRAIAIMIGFQILIGWFMFATKIGQQIIIFISKVFNKLIKLGTTGVDFLFNG
IHRDFVFFLNVLLIIVFFSALLSIFSYLGVLPFIVRVVGGAISKITGLPRVESFHAVNSVFFGSSEALIVIKNDLQHFNK
NRMFIICCSAMSSVSASVTASYVMMLDAKYVLAALPLNLFSSLIVCSLLTPVDTKKEDEVIQKFDRTLFGDSFIGAMING
ALDGLKVAGIVAALMIAFIGVMEVVNYVISAASGAMGHAVTLQQIFGYVLSPFAFLMGIPTQDIIPAGGIMGTKIVLNEF
VAILDLKDTATTLAPRTVGIVTVFLISFASISQIGAIVGTIRALSEKQGSVVSKFGWKMLFASTLASILSATIAGLFI
>Mature_398_residues
MQYVMSIIGILAVLGLCFALSNNKSKINFRAIAIMIGFQILIGWFMFATKIGQQIIIFISKVFNKLIKLGTTGVDFLFNG
IHRDFVFFLNVLLIIVFFSALLSIFSYLGVLPFIVRVVGGAISKITGLPRVESFHAVNSVFFGSSEALIVIKNDLQHFNK
NRMFIICCSAMSSVSASVTASYVMMLDAKYVLAALPLNLFSSLIVCSLLTPVDTKKEDEVIQKFDRTLFGDSFIGAMING
ALDGLKVAGIVAALMIAFIGVMEVVNYVISAASGAMGHAVTLQQIFGYVLSPFAFLMGIPTQDIIPAGGIMGTKIVLNEF
VAILDLKDTATTLAPRTVGIVTVFLISFASISQIGAIVGTIRALSEKQGSVVSKFGWKMLFASTLASILSATIAGLFI

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI42542381, Length=424, Percent_Identity=25.2358490566038, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI11545853, Length=415, Percent_Identity=24.8192771084337, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI227116277, Length=416, Percent_Identity=25, Blast_Score=112, Evalue=4e-25,
Organism=Escherichia coli, GI1788737, Length=394, Percent_Identity=40.6091370558376, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1788485, Length=418, Percent_Identity=32.0574162679426, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1788488, Length=417, Percent_Identity=32.1342925659472, Blast_Score=191, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI71991794, Length=394, Percent_Identity=25.3807106598985, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17560276, Length=394, Percent_Identity=24.1116751269036, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45552519, Length=394, Percent_Identity=25.3807106598985, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45552517, Length=394, Percent_Identity=25.3807106598985, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI19921868, Length=394, Percent_Identity=25.3807106598985, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281360430, Length=391, Percent_Identity=25.5754475703325, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 42832; Mature: 42832

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYVMSIIGILAVLGLCFALSNNKSKINFRAIAIMIGFQILIGWFMFATKIGQQIIIFIS
CHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVFNKLIKLGTTGVDFLFNGIHRDFVFFLNVLLIIVFFSALLSIFSYLGVLPFIVRVVGG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISKITGLPRVESFHAVNSVFFGSSEALIVIKNDLQHFNKNRMFIICCSAMSSVSASVTA
HHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHHCCCCCEEEEEECHHHHHHHHHHH
SYVMMLDAKYVLAALPLNLFSSLIVCSLLTPVDTKKEDEVIQKFDRTLFGDSFIGAMING
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
ALDGLKVAGIVAALMIAFIGVMEVVNYVISAASGAMGHAVTLQQIFGYVLSPFAFLMGIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
TQDIIPAGGIMGTKIVLNEFVAILDLKDTATTLAPRTVGIVTVFLISFASISQIGAIVGT
CHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IRALSEKQGSVVSKFGWKMLFASTLASILSATIAGLFI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQYVMSIIGILAVLGLCFALSNNKSKINFRAIAIMIGFQILIGWFMFATKIGQQIIIFIS
CHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KVFNKLIKLGTTGVDFLFNGIHRDFVFFLNVLLIIVFFSALLSIFSYLGVLPFIVRVVGG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AISKITGLPRVESFHAVNSVFFGSSEALIVIKNDLQHFNKNRMFIICCSAMSSVSASVTA
HHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEECHHHHCCCCCEEEEEECHHHHHHHHHHH
SYVMMLDAKYVLAALPLNLFSSLIVCSLLTPVDTKKEDEVIQKFDRTLFGDSFIGAMING
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
ALDGLKVAGIVAALMIAFIGVMEVVNYVISAASGAMGHAVTLQQIFGYVLSPFAFLMGIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
TQDIIPAGGIMGTKIVLNEFVAILDLKDTATTLAPRTVGIVTVFLISFASISQIGAIVGT
CHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
IRALSEKQGSVVSKFGWKMLFASTLASILSATIAGLFI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]